(Q39970523)

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PGE2 maintains the tone of the guinea pig trachea through a balance between activation of contractile EP1 receptors and relaxant EP2 receptors

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Europe PubMed Central

PMC publication ID

16 September 2017

PGE2 maintains the tone of the guinea pig trachea through a balance between activation of contractile EP1 receptors and relaxant EP2 receptors (English)

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

author name string

J Säfholm

1

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

S-E Dahlén

2

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

I Delin

3

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

K Maxey

4

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

K Stark

5

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

L-O Cardell

6

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

M Adner

7

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

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publication date

1 February 2013

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

British Journal of Pharmacology

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Europe PubMed Central

PMC publication ID

16 September 2017

168

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

4

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

794-806

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

PGE(2) receptor (EP(4)) agonists: potent dilators of human bronchi and future asthma therapy?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

22 September 2017

EP4 receptor as a new target for bronchodilator therapy

1 reference

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22 September 2017

In vitro and in vivo characterization of PF-04418948, a novel, potent and selective prostaglandin EP₂ receptor antagonist

1 reference

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22 September 2017

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

1 reference

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22 September 2017

Prostaglandin E2 mediates cough via the EP3 receptor: implications for future disease therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

22 September 2017

Prostanoid receptor antagonists: development strategies and therapeutic applications

1 reference

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22 September 2017

Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion

1 reference

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22 September 2017

The guinea pig as an animal model for asthma.

1 reference

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22 September 2017

Using guinea pigs in studies relevant to asthma and COPD.

1 reference

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22 September 2017

Prostaglandin E2-EP4 receptor promotes endothelial cell migration via ERK activation and angiogenesis in vivo

1 reference

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22 September 2017

A new class of nitric oxide-releasing derivatives of cetirizine; pharmacological profile in vascular and airway smooth muscle preparations.

1 reference

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22 September 2017

Prostaglandins, bioassay and inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

22 September 2017

Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

22 September 2017

E-ring 8-isoprostanes inhibit ACh release from parasympathetic nerves innervating guinea-pig trachea through agonism of prostanoid receptors of the EP3-subtype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

22 September 2017

Activation of prostaglandin E2-receptor EP2 and EP4 pathways induces growth inhibition in human gastric carcinoma cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

22 September 2017

Prostaglandin E(2) increases cyclic AMP and inhibits endothelin-1 production/secretion by guinea-pig tracheal epithelial cells through EP(4) receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

22 September 2017

The analgesic effect profile of FR122047, a selective cyclooxygenase-1 inhibitor, in chemical nociceptive models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

22 September 2017

The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

22 September 2017

Characterization of airway and vascular responses in murine lungs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

22 September 2017

Characterization of a prostanoid EP3-receptor in guinea-pig aorta: partial agonist action of the non-prostanoid ONO-AP-324

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

22 September 2017

Inherent tone of human bronchus: role of eicosanoids and the epithelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

22 September 2017

Involvement of cyclooxygenase 2 (COX-2) in intrinsic tone of isolated guinea pig trachea

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

22 September 2017

Contractile and relaxant actions of prostaglandins on guinea-pig isolated trachea

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

22 September 2017

Arrestin specificity for G protein-coupled receptors in human airway smooth muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

25 September 2017

Interaction of prostanoid EP3 and TP receptors in guinea‐pig isolated aorta: contractile self‐synergism of 11‐deoxy‐16,16‐dimethyl PGE2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

17 June 2018

An assay to evaluate the long-term effects of inflammatory mediators on murine airway smooth muscle: evidence that TNFalpha up-regulates 5-HT(2A)-mediated contraction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

17 June 2018

Characterization of the prostaglandin E2 sensitive (EP)-receptor in the rat isolated trachea

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

17 June 2018

Histamine, endogenous prostaglandins and cyclic nucleotides in the regulation of airway muscle responses in the guinea pig.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

17 June 2018

Studies on the characterisation of prostanoid receptors: a proposed classification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

17 June 2018

Antagonism of tone and prostaglandin-mediated responses in a tracheal preparation by indomethacin and SC-19220.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

17 June 2018

Is the epithelium-derived inhibitory factor in guinea-pig trachea a prostanoid?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

17 June 2018

Is the guinea pig trachea a good in vitro model of human large and central airways? Comparison on leukotriene-, methacholine-, histamine- and antigen-induced contractions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

17 June 2018

Specific desensitization to PGE1 and PGE2 in guinea-pig ileum; evidence for a common receptor síte

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

17 June 2018

Roles of affinity and lipophilicity in the slow kinetics of prostanoid receptor antagonists on isolated smooth muscle preparations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

20 August 2018

Characterization of biosynthesis and modes of action of prostaglandin E2 and prostacyclin in guinea pig mesenteric lymphatic vessels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

20 August 2018

Two different mechanisms for modulation of bronchoconstriction in guinea-pigs by cyclooxygenase metabolites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

20 August 2018

COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

20 August 2018

Activation of prostaglandin E receptor EP4 subtype suppresses food intake in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

20 August 2018

Characterisation of guinea pig precision-cut lung slices: comparison with human tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

20 August 2018

Organ-cultured airway explants: a new model of airway hyperresponsiveness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

20 August 2018

Cyclooxygenase-2 expression during allergic inflammation in guinea-pig lungs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

20 August 2018

Regulation of baseline cholinergic tone in guinea-pig airway smooth muscle.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

20 August 2018

Desensitization of PGE2 and PGI2 induced contractions in different smooth muscles of guinea-pig unmasking relaxing properties of prostanoids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631371

20 August 2018

Activation of prostaglandin E2-receptor EP2 and EP4 pathways induces growth inhibition in human gastric carcinoma cell lines

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2012.02189.X

21 January 2018

Prostaglandin regulation of airway smooth muscle tone

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2012.02189.X

21 January 2018

Bronchoprotective role for endogenous prostaglandin E2

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2012.02189.X

21 January 2018

Biosynthesis of prostaglandins from arachidonic acid in guinea pig lung. Prostaglandins and related factors. 38

1 reference

https://pubmed.ncbi.nlm.nih.gov/22934927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific receptors for prostaglandins in airways

1 reference

https://pubmed.ncbi.nlm.nih.gov/22934927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterisation of the prostanoid receptors mediating contraction of guinea-pig isolated trachea

1 reference

https://pubmed.ncbi.nlm.nih.gov/22934927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The development of tone in the smooth muscle of guinea-pig isolated tracheal preparations may be influenced by prostanoids released from the adjacent airway cartilage

1 reference

https://pubmed.ncbi.nlm.nih.gov/22934927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pulmonary responses to bronchoconstrictor agonists in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/22934927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leukotrienes and histamine mediate IgE-dependent contractions of human bronchi: pharmacological evidence obtained with tissues from asthmatic and non-asthmatic subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/22934927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exercise-induced refractoriness in asthmatic subjects involves leukotriene and prostaglandin interdependent mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/22934927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of inhaled PGE2 on exercise-induced bronchoconstriction in asthmatic subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/22934927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms for the mechanical plasticity of tracheal smooth muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/22934927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a monoclonal antibody that neutralizes the activity of prostaglandin E2

1 reference

https://pubmed.ncbi.nlm.nih.gov/22934927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolated, electrically-stimulated airway preparations--their use in determining beta-adrenoceptor agonist activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22934927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EP1 receptor blockade attenuates both spontaneous tone and PGE2-elicited contraction in guinea pig trachealis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22934927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effects of inhaled PGE2 on allergen-induced airway responses and airway inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22934927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of prostaglandin E receptor EP3 subtype in duodenal bicarbonate secretion in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22934927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1476-5381.2012.02189.X

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

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