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Site-specific, Rep-mediated integration of the intact beta-globin locus in the human erythroleukaemic cell line K562.
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Europe PubMed Central
PubMed publication ID
18496574
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18496574%20AND%20SRC:MED&resulttype=core&format=json
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7 January 2020
title
Site-specific, Rep-mediated integration of the intact beta-globin locus in the human erythroleukaemic cell line K562
(English)
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Europe PubMed Central
PubMed publication ID
18496574
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18496574%20AND%20SRC:MED&resulttype=core&format=json
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7 January 2020
main subject
cell line
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author
Sara E. Howden
series ordinal
1
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Europe PubMed Central
PubMed publication ID
18496574
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18496574%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
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L Voullaire
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2
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PubMed publication ID
18496574
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18496574%20AND%20SRC:MED&resulttype=core&format=json
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7 January 2020
H Wardan
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3
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PubMed publication ID
18496574
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18496574%20AND%20SRC:MED&resulttype=core&format=json
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7 January 2020
R Williamson
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4
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18496574
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7 January 2020
J Vadolas
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5
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PubMed publication ID
18496574
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18496574%20AND%20SRC:MED&resulttype=core&format=json
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7 January 2020
publication date
22 May 2008
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18496574
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18496574%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
published in
Gene Therapy
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PubMed publication ID
18496574
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7 January 2020
volume
15
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18496574
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18496574%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
issue
20
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PubMed publication ID
18496574
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18496574%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
page(s)
1372-1383
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Europe PubMed Central
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18496574
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18496574%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
exact match
https://scigraph.springernature.com/pub.10.1038/gt.2008.84
0 references
cites work
Gene silencing as a threat to the success of gene therapy
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Position effects on eukaryotic gene expression
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A physical map of the human genome
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Correction of deafness in shaker-2 mice by an unconventional myosin in a BAC transgene.
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BAC-mediated gene-dosage analysis reveals a role for Zipro1 (Ru49/Zfp38) in progenitor cell proliferation in cerebellum and skin
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Stable correction of a genetic deficiency in human cells by an episome carrying a 115 kb genomic transgene
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Genomic studies of gene expression: regulation of the Wilson disease gene
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Human BAC-mediated rescue of the Friedreich ataxia knockout mutation in transgenic mice
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7 January 2021
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Transgene copy number-dependent rescue of murine beta-globin knockout mice carrying a 183 kb human beta-globin BAC genomic fragment
1 reference
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7 January 2021
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Site-specific integration by adeno-associated virus
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7 January 2021
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Mapping and direct visualization of a region-specific viral DNA integration site on chromosome 19q13-qter
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FGT.2008.84
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7 January 2021
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Targeted integration of adeno-associated virus (AAV) into human chromosome 19
1 reference
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https://api.crossref.org/works/10.1038%2FGT.2008.84
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7 January 2021
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Adeno-associated virus DNA replication: Nonunit-length molecules
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FGT.2008.84
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7 January 2021
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Adeno-associated virus general transduction vectors: analysis of proviral structures
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7 January 2021
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Site-specific integration by adeno-associated virus is directed by a cellular DNA sequence
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FGT.2008.84
retrieved
7 January 2021
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Adeno-associated virus (AAV) Rep proteins mediate complex formation between AAV DNA and its integration site in human DNA
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FGT.2008.84
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7 January 2021
based on heuristic
inferred from DOI database lookup
Site-specific integration by adeno-associated virus
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FGT.2008.84
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7 January 2021
based on heuristic
inferred from DOI database lookup
The recombination signals for adeno-associated virus site-specific integration
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FGT.2008.84
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Adeno-associated virus Rep78 protein and terminal repeats enhance integration of DNA sequences into the cellular genome
1 reference
stated in
Crossref
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https://api.crossref.org/works/10.1038%2FGT.2008.84
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7 January 2021
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Adeno-associated virus Rep proteins target DNA sequences to a unique locus in the human genome
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FGT.2008.84
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7 January 2021
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Targeted integration of adeno-associated virus-derived plasmids in transfected human cells.
1 reference
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Site-specific integration of adeno-associated virus-based plasmid vectors in lipofected HeLa cells
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FGT.2008.84
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7 January 2021
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Targeted integration of foreign DNA into a defined locus on chromosome 19 in K562 cells using AAV-derived components
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FGT.2008.84
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7 January 2021
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A p5 integration efficiency element mediates Rep-dependent integration into AAVS1 at chromosome 19.
1 reference
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Crossref
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A 16bp Rep binding element is sufficient for mediating Rep-dependent integration into AAVS1.
1 reference
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Crossref
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Embryonic-fetal erythroid characteristics of a human leukemic cell line
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Efficient cell proliferation and predominant accumulation of epsilon-globin mRNA in human leukemic K562 cells which produce mostly Hb Gower 1.
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The transient expression of mRNA coding for Rep protein from AAV facilitates targeted plasmid integration.
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Development of sensitive fluorescent assays for embryonic and fetal hemoglobin inducers using the human beta -globin locus in erythropoietic cells
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Efficient and precise engineering of a 200 kb beta-globin human/bacterial artificial chromosome in E. coli DH10B using an inducible homologous recombination system
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Engineering EGFP reporter constructs into a 200 kb human beta-globin BAC clone using GET Recombination
1 reference
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Identifiers
DOI
10.1038/GT.2008.84
1 reference
stated in
Europe PubMed Central
PubMed publication ID
18496574
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18496574%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
PubMed publication ID
18496574
1 reference
stated in
Europe PubMed Central
PubMed publication ID
18496574
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18496574%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
ResearchGate publication ID
5352774
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