(Q40005550)

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A vicious cycle involving release of heat shock protein 60 from injured cells and activation of toll-like receptor 4 mediates neurodegeneration in the CNS.

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Europe PubMed Central

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3 January 2020

A vicious cycle involving release of heat shock protein 60 from injured cells and activation of toll-like receptor 4 mediates neurodegeneration in the CNS (English)

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3 January 2020

toll-like receptor

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neurodegeneration

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based on heuristic

inferred from title

Thorsten Trimbuch

3

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3 January 2020

author name string

Seija Lehnardt

1

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3 January 2020

Eckart Schott

2

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3 January 2020

Dinah Laubisch

4

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3 January 2020

Christina Krueger

5

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3 January 2020

Gregory Wulczyn

6

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3 January 2020

Robert Nitsch

7

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3 January 2020

Joerg R Weber

8

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3 January 2020

language of work or name

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publication date

1 March 2008

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3 January 2020

Journal of Neuroscience

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3 January 2020

28

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3 January 2020

10

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3 January 2020

2320-2331

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3 January 2020

Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human 60-kDa heat-shock protein: a danger signal to the innate immune system

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unresponsiveness of MyD88-deficient mice to endotoxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis and the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Innate immune recognition: mechanisms and pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The relationship between neuronal survival and regeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Self-repair in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oligosaccharides of hyaluronan are potent activators of dendritic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extracellular ATP and TNF-alpha synergize in the activation and maturation of human dendritic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis in neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drosophila MyD88 is an adapter in the Toll signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Primary tumor tissue lysates are enriched in heat shock proteins and induce the maturation of human dendritic cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The danger model: a renewed sense of self

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation in neurodegenerative disease--a double-edged sword

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regenerating nerves follow the road more traveled

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Broad expression of Toll-like receptors in the human central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The impact of systemic infection on the progression of neurodegenerative disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recombinant human heat shock protein 60 does not induce the release of tumor necrosis factor alpha from murine macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activated microglia mediate neuronal cell injury via a nitric oxide mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heat shock proteins as endogenous adjuvants in sterile and septic inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathogen recognition and innate immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toll-like receptor 2 signaling in response to brain injury: an innate bridge to neuroinflammation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The polarity of the dorsoventral axis in the Drosophila embryo is defined by an extracellular signal

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Response of endogenous glial cells to motor neuron degeneration induced by toxic ricin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive nitrogen intermediates in human neuropathology: an overview

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interferon-gamma-induced oligodendrocyte cell death: implications for the pathogenesis of multiple sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia: a sensor for pathological events in the CNS

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of MPTP toxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)

1 reference

https://pubmed.ncbi.nlm.nih.gov/18322079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.4760-07.2008

1 reference

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3 January 2020

release_slo5vbabejhpthtjdexbs4au5y

1 reference

https://api.fatcat.wiki/v0/release/slo5vbabejhpthtjdexbs4au5y

24 November 2022

based on heuristic

mapped directly with Wikidata item

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18322079%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18322079%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

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