(Q40015350)

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Activation of transgene expression by early region 4 is responsible for a high level of persistent transgene expression from adenovirus vectors in vivo

scientific article published on December 1997

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Europe PubMed Central

PMC publication ID

16 September 2017

Activation of transgene expression by early region 4 is responsible for a high level of persistent transgene expression from adenovirus vectors in vivo (English)

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

1 reference

based on heuristic

inferred from title

7

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Europe PubMed Central

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16 September 2017

author name string

Brough DE

1

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Europe PubMed Central

PMC publication ID

16 September 2017

Hsu C

2

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Europe PubMed Central

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16 September 2017

Kulesa VA

3

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

Lee GM

4

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

Cantolupo LJ

5

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Europe PubMed Central

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16 September 2017

Lizonova A

6

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16 September 2017

language of work or name

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publication date

1 December 1997

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Europe PubMed Central

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16 September 2017

Journal of Virology

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16 September 2017

71

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Europe PubMed Central

PMC publication ID

16 September 2017

12

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

9206-9213

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

Long-term gene delivery into the livers of immunocompetent mice with E1/E4-defective adenoviruses

1 reference

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Mutant adenovirus type 9 E4 ORF1 genes define three protein regions required for transformation of CREF cells.

1 reference

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22 September 2017

Transient immunomodulation with anti-CD40 ligand antibody and CTLA4Ig enhances persistence and secondary adenovirus-mediated gene transfer into mouse liver

1 reference

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22 September 2017

Persistence in muscle of an adenoviral vector that lacks all viral genes

1 reference

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The adenovirus E4orf6 protein can promote E1A/E1B-induced focus formation by interfering with p53 tumor suppressor function

1 reference

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22 September 2017

Effect of the E4 region on the persistence of transgene expression from adenovirus vectors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230223

22 September 2017

Human adenovirus early region 4 open reading frame 1 genes encode growth-transforming proteins that may be distantly related to dUTP pyrophosphatase enzymes

1 reference

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22 September 2017

Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ

1 reference

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22 September 2017

Adenovirus infection stimulates the Raf/MAPK signaling pathway and induces interleukin-8 expression

1 reference

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22 September 2017

Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo

1 reference

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22 September 2017

Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy.

1 reference

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22 September 2017

A gene transfer vector-cell line system for complete functional complementation of adenovirus early regions E1 and E4.

1 reference

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22 September 2017

Transient subversion of CD40 ligand function diminishes immune responses to adenovirus vectors in mouse liver and lung tissues

1 reference

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22 September 2017

Adenovirus early region 4 34-kilodalton protein directs the nuclear localization of the early region 1B 55-kilodalton protein in primate cells.

1 reference

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22 September 2017

Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis

1 reference

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22 September 2017

A new adenoviral vector: Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase

1 reference

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22 September 2017

Lack of persistence of E1- recombinant adenoviral vectors containing a temperature-sensitive E2A mutation in immunocompetent mice and hemophilia B dogs

1 reference

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22 September 2017

Human adenovirus type 9 E4 open reading frame 1 encodes a cytoplasmic transforming protein capable of increasing the oncogenicity of CREF cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230223

22 September 2017

Human adenovirus encodes two proteins which have opposite effects on accumulation of alternatively spliced mRNAs.

1 reference

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22 September 2017

Adenovirus E4orf4 protein binds to protein phosphatase 2A, and the complex down regulates E1A-enhanced junB transcription.

1 reference

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22 September 2017

Adenovirus type 9 E4 open reading frame 1 encodes a transforming protein required for the production of mammary tumors in rats

1 reference

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22 September 2017

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230223

22 September 2017

Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver

1 reference

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22 September 2017

Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230223

22 September 2017

Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230223

22 September 2017

Upregulation of class I major histocompatibility complex antigens by interferon gamma is necessary for T-cell-mediated elimination of recombinant adenovirus-infected hepatocytes in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230223

22 September 2017

Transfer of genes to humans: early lessons and obstacles to success

1 reference

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22 September 2017

Introduction, stable integration, and controlled expression of a chimeric adenovirus gene whose product is toxic to the recipient human cell

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230223

22 September 2017

Adenovirus early region 4 is essential for normal stability of late nuclear RNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230223

22 September 2017

Adenovirus early region 4 stimulates mRNA accumulation via 5' introns

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230223

22 September 2017

Human adenovirus type 9-induced rat mammary tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230223

22 September 2017

Utilization of cellular transcription factors for adenovirus-induced transcription

1 reference

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22 September 2017

Adenovirus E4orf4 protein reduces phosphorylation of c-Fos and E1A proteins while simultaneously reducing the level of AP-1

1 reference

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22 September 2017

To kill or to cure: options in host defense against viral infection.

1 reference

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25 September 2017

Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor

1 reference

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25 September 2017

Adenovirus replication is coupled with the dynamic properties of the PML nuclear structure.

1 reference

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25 September 2017

FK506 immunosuppression to control the immune reactions triggered by first-generation adenovirus-mediated gene transfer

1 reference

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25 September 2017

Nondepleting anti-CD4 antibody treatment prolongs lung-directed E1-deleted adenovirus-mediated gene expression in rats

1 reference

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15 June 2018

Cyclophosphamide diminishes inflammation and prolongs transgene expression following delivery of adenoviral vectors to mouse liver and lung.

1 reference

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Prolonged transgene expression in cotton rat lung with recombinant adenoviruses defective in E2a.

1 reference

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The impact of developmental stage, route of administration and the immune system on adenovirus-mediated gene transfer

1 reference

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Long-term hepatic adenovirus-mediated gene expression in mice following CTLA4Ig administration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230223

15 June 2018

MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses.

1 reference

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Mechanism of activation of early viral transcription by the adenovirus E1A gene product

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230223

15 June 2018

Requirement for the adenovirus type 9 E4 region in production of mammary tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230223

15 June 2018

Transient immune blockade prevents formation of neutralizing antibody to recombinant adenovirus and allows repeated gene transfer to mouse liver.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230223

20 August 2018

Characterization of factors involved in modulating persistence of transgene expression from recombinant adenovirus in the mouse lung

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230223

20 August 2018

Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration.

1 reference

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CD40 ligand-dependent T cell activation: requirement of B7-CD28 signaling through CD40.

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Mammary tumors induced by human adenovirus type 9: a role for the viral early region 4 gene

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Two adenovirus proteins with redundant activities in virus growth facilitates tripartite leader mRNA accumulation

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Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: comparisons between immunocompetent and immunodeficient inbred strains.

1 reference

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Clearance of adenovirus-infected hepatocytes by MHC class I-restricted CD4+ CTLs in vivo

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Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix-associated PML bodies.

1 reference

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Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis.

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Secreted placental alkaline phosphatase: a powerful new quantitative indicator of gene expression in eukaryotic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9371579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of factors involved in regulated adenovirus-2 major late pre-mRNA splicing

1 reference

https://pubmed.ncbi.nlm.nih.gov/9371579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metabolism of host RNAs in cells infected by an adenovirus E4 mutant

1 reference

https://pubmed.ncbi.nlm.nih.gov/9371579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Persistence of Replication-Deficient Adenovirus-Mediated Gene Transfer in Lungs of Immune-Deficient (nu/nu) Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/9371579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of transient CD4 lymphocyte depletion to prolong transgene expression of E1-deleted adenoviral vectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/9371579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/JVI.71.12.9206-9213.1997

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

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