(Q40024513)

English

Roflumilast N-oxide, a PDE4 inhibitor, improves cilia motility and ciliated human bronchial epithelial cells compromised by cigarette smoke in vitro

scientific article published on August 2012

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scholarly article

1 reference

Europe PubMed Central

16 September 2017

Roflumilast N-oxide, a PDE4 inhibitor, improves cilia motility and ciliated human bronchial epithelial cells compromised by cigarette smoke in vitro (English)

1 reference

Europe PubMed Central

16 September 2017

1 reference

ChEBI release 2020-05-28

author name string

J Milara

1

1 reference

Europe PubMed Central

16 September 2017

M Armengot

2

1 reference

Europe PubMed Central

16 September 2017

P Bañuls

3

1 reference

Europe PubMed Central

16 September 2017

H Tenor

4

1 reference

Europe PubMed Central

16 September 2017

Rolf Beume

5

1 reference

Europe PubMed Central

16 September 2017

E Artigues

6

1 reference

Europe PubMed Central

16 September 2017

J Cortijo

7

1 reference

Europe PubMed Central

16 September 2017

language of work or name

0 references

publication date

1 August 2012

1 reference

Europe PubMed Central

16 September 2017

British Journal of Pharmacology

1 reference

Europe PubMed Central

16 September 2017

166

1 reference

Europe PubMed Central

16 September 2017

8

1 reference

Europe PubMed Central

16 September 2017

2243-2262

1 reference

Europe PubMed Central

16 September 2017

Adenosine activation of A(2B) receptor(s) is essential for stimulated epithelial ciliary motility and clearance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

Goblet cells are derived from a FOXJ1-expressing progenitor in a human airway epithelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

Cilia motility and structure in primary and secondary ciliary dyskinesia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

Increased cytokine response of rhinovirus-infected airway epithelial cells in chronic obstructive pulmonary disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

The preclinical pharmacology of roflumilast--a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

Long-term cigarette smoke exposure in a mouse model of ciliated epithelial cell function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

Receptor activation of NADPH oxidases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

Purinergic receptors in airway epithelia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

Foxj1 transcription factors are master regulators of the motile ciliogenic program

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

DNAI2 mutations cause primary ciliary dyskinesia with defects in the outer dynein arm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

A2B adenosine receptors regulate the mucus clearance component of the lung's innate defense system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

Dual oxidase 1 and 2 expression in airway epithelium of smokers and patients with mild/moderate chronic obstructive pulmonary disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

IL-13 regulates cilia loss and foxj1 expression in human airway epithelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

Lung development and repair: contribution of the ciliated lineage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

Effects of cigarette smoke and alcohol on ciliated tracheal epithelium and inflammatory cell recruitment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

Real-time analysis of cAMP-mediated regulation of ciliary motility in single primary human airway epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

Oxidative stress employs phosphatidyl inositol 3-kinase and ERK signalling pathways to activate cAMP phosphodiesterase-4D3 (PDE4D3) through multi-site phosphorylation at Ser239 and Ser579.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

Regulation of mammalian ciliary beating.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

Keynote review: phosphodiesterase-4 as a therapeutic target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

COPD, a multicomponent disease: implications for management

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

Phosphodiesterase 4D forms a cAMP diffusion barrier at the apical membrane of the airway epithelium.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

Tobacco smoke control of mucin production in lung cells requires oxygen radicals AP-1 and JNK.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

NADPH oxidase-dependent acid production in airway epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

Effects of paramyxoviral infection on airway epithelial cell Foxj1 expression, ciliogenesis, and mucociliary function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

22 September 2017

Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin-induced lung injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

25 September 2017

Mucociliary clearance in the airways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

25 September 2017

Effects of salmeterol on cilia and mucus in COPD and pneumonia patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

15 June 2018

Effects of SCA40 on human isolated bronchus and human polymorphonuclear leukocytes: comparison with rolipram, SKF94120 and levcromakalim

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

15 June 2018

Protein kinase C-dependent phosphorylation of a ciliary membrane protein and inhibition of ciliary beating.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

15 June 2018

NADPH oxidase 4 mediates upregulation of type 4 phosphodiesterases in human endothelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

20 August 2018

Effect of cyclic AMP-elevating agents on airway ciliary beat frequency in central and lateral airways in rat precision-cut lung slices

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

20 August 2018

Direct effect of cigarette smoke on human pulmonary artery tension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

20 August 2018

Involvement of IL-13 in tobacco smoke-induced changes in the structure and function of rat intrapulmonary airways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

20 August 2018

Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

20 August 2018

Cigarette smoke exposure impairs respiratory epithelial ciliogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

20 August 2018

Dual role of NOX2 in respiratory syncytial virus- and sendai virus-induced activation of NF-kappaB in airway epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

20 August 2018

Cigarette smoke condensate induces MMP-12 gene expression in airway-like epithelia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

20 August 2018

Effects of phosphodiesterase inhibitors on interleukin-4 and interleukin-13 generation from human basophils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

20 August 2018

Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

20 August 2018

Interleukin-13 and -4 expression in the central airways of smokers with chronic bronchitis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

20 August 2018

Prenatal cigarette smoke decreases lung cAMP and increases airway hyperresponsiveness.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

20 August 2018

Differential effects of UTP, ATP, and adenosine on ciliary activity of human nasal epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

20 August 2018

Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

20 August 2018

Quantitative multiwell myeloid differentiation assay using dichlorodihydrofluorescein diacetate (H2DCF-DA) or dihydrorhodamine 123 (H2R123).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448891

20 August 2018

Experimental effect of cigarette smoke on human respiratory cilia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22385203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetaldehyde-stimulated PKC activity in airway epithelial cells treated with smoke extract from normal and smokeless cigarettes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22385203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different lung responses to cigarette smoke in two strains of mice sensitive to oxidants

1 reference

https://pubmed.ncbi.nlm.nih.gov/22385203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Superoxide auto-augments superoxide formation and upregulates gp91(phox) expression in porcine pulmonary artery endothelial cells: inhibition by iloprost

1 reference

https://pubmed.ncbi.nlm.nih.gov/22385203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dose-proportional intraindividual single- and repeated-dose pharmacokinetics of roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/22385203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assay of cyclic nucleotide phosphodiesterases with radioactive substrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/22385203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative analysis of the hydrogen peroxide formed in aqueous cigarette tar extracts

1 reference

https://pubmed.ncbi.nlm.nih.gov/22385203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mucociliary clearance in healthy men at rest and during exercise

1 reference

https://pubmed.ncbi.nlm.nih.gov/22385203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Smoke and viral infection cause cilia loss detectable by bronchoalveolar lavage cytology and dynein ELISA

1 reference

https://pubmed.ncbi.nlm.nih.gov/22385203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cigarette smoke condensate inhibits transepithelial chloride transport and ciliary beat frequency

1 reference

https://pubmed.ncbi.nlm.nih.gov/22385203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of IL-13 on mucociliary differentiation of pediatric asthmatic bronchial epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22385203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ciliary abnormalities in bronchial epithelium of smokers, ex-smokers, and nonsmokers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22385203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of interleukin-13 by type 4 cyclic nucleotide phosphodiesterase (PDE) inhibitors in allergen-specific human T lymphocyte clones

1 reference

https://pubmed.ncbi.nlm.nih.gov/22385203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of selective phosphodiesterase inhibitors on mucociliary activity in the upper and lower airways in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/22385203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of cigarette smoke extract on nitric oxide synthase in pulmonary artery endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22385203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1476-5381.2012.01929.X

1 reference

Europe PubMed Central

16 September 2017

1 reference

Europe PubMed Central

16 September 2017

1 reference

Europe PubMed Central

16 September 2017

ResearchGate publication ID

0 references

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