(Q40025076)

English

Inhibition of proteasome by bortezomib causes intracellular aggregation of hepatic serpins and increases the latent circulating form of antithrombin.

scientific article published on 14 January 2008

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18195690%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Inhibition of proteasome by bortezomib causes intracellular aggregation of hepatic serpins and increases the latent circulating form of antithrombin (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18195690%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Marcos González Díaz

9

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1 January 2020

Vicente Vicente

10

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1 January 2020

11

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1 January 2020

author name string

David Hernández-Espinosa

1

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1 January 2020

Antonia Miñano

2

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1 January 2020

Constantino Martínez

3

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1 January 2020

Adriana Ordoñez

4

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1 January 2020

Elena Pérez-Ceballos

5

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1 January 2020

Felipe de Arriba

6

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1 January 2020

Rubén A Mota

7

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1 January 2020

Francisca Ferrer

8

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1 January 2020

publication date

14 January 2008

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1 January 2020

Laboratory Investigation

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1 January 2020

88

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1 January 2020

3

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1 January 2020

306-317

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1 January 2020

Serpinopathies and the conformational dementias

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700717

21 January 2018

ERAD: the long road to destruction

1 reference

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21 January 2018

Cell toxicity and conformational disease.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700717

21 January 2018

Intracellular degradation of secretion defect-type mutants of antithrombin is inhibited by proteasomal inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700717

21 January 2018

Elucidation of the molecular logic by which misfolded alpha 1-antitrypsin is preferentially selected for degradation.

1 reference

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21 January 2018

The proteasome participates in degradation of mutant alpha 1-antitrypsin Z in the endoplasmic reticulum of hepatoma-derived hepatocytes

1 reference

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21 January 2018

Mutants of neuroserpin that cause dementia accumulate as polymers within the endoplasmic reticulum

1 reference

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21 January 2018

Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting

1 reference

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21 January 2018

Latent antithrombin and its detection, formation and turnover in the circulation

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700717

21 January 2018

Detection of conformational transformation of antithrombin in blood with crossed immunoelectrophoresis: new application for a classical method

1 reference

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21 January 2018

L-asparaginase-induced antithrombin type I deficiency: implications for conformational diseases.

1 reference

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21 January 2018

A phase 2 study of bortezomib in relapsed, refractory myeloma

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21 January 2018

Heat shock proteins are present in mallory bodies (cytokeratin aggresomes) in human liver biopsy specimens

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700717

21 January 2018

Prothrombin biosynthesis: characterization of processing events in rat liver microsomes.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700717

21 January 2018

Molecular mechanisms accounting for fibrinogen deficiency: from large deletions to intracellular retention of misfolded proteins

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700717

21 January 2018

Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700717

21 January 2018

Dislocation and degradation from the ER are regulated by cytosolic stress

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700717

21 January 2018

Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700717

21 January 2018

Proteasome inhibitors MG132 and lactacystin hyperphosphorylate HSF1 and induce hsp70 and hsp27 expression

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700717

21 January 2018

Conformational disease

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700717

21 January 2018

In vivo effects of hyperthermia on the functional and conformational characteristics of antithrombin.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700717

21 January 2018

Alpha1-antitrypsin deficiency. 4: Molecular pathophysiology

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700717

21 January 2018

Aggresomes: a cellular response to misfolded proteins

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700717

21 January 2018

Aggresome formation in liver cells in response to different toxic mechanisms: role of the ubiquitin-proteasome pathway and the frameshift mutant of ubiquitin

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700717

21 January 2018

The proteasome inhibitor, PS-341, causes cytokeratin aggresome formation

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700717

21 January 2018

The origin and role of confronting cisternae in selected fetal mouse and rat tissues

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21 January 2018

Mallory body--a disease-associated type of sequestosome

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700717

21 January 2018

Heat shock response and protein degradation: regulation of HSF2 by the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700717

21 January 2018

Antithrombin Phe229Leu: a new homozygous variant leading to spontaneous antithrombin polymerization in vivo associated with severe childhood thrombosis.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700717

21 January 2018

Antithrombin: a new look at the actions of a serine protease inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700717

21 January 2018

Phase II trial of PS-341 in patients with renal cell cancer: a University of Chicago phase II consortium study

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700717

21 January 2018

Bortezomib-induced severe hepatitis in multiple myeloma: a case report

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21 January 2018

Severe pulmonary complications in Japanese patients after bortezomib treatment for refractory multiple myeloma

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21 January 2018

Rapid response to high-dose steroids of severe bortezomib-related pulmonary complication in multiple myeloma.

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21 January 2018

Thalidomide in multiple myeloma: past, present and future

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21 January 2018

How serpins change their fold for better and for worse

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7 January 2021

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Cellular and functional characterization of three recombinant antithrombin mutants that caused pleiotropic effect-type deficiency

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7 January 2021

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Bortezomib: proteasome inhibition as an effective anticancer therapy

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7 January 2021

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Thromboembolic disease due to thermolabile conformational changes of antithrombin Rouen-VI (187 Asn-->Asp)

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7 January 2021

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Process of carboxylation of glutamic acid residues in the gla domain of human des-gamma-carboxyprothrombin

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7 January 2021

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Intracellular retention of hepatic serpins caused by severe hyperlipidemia

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Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

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HIV as a cause of giant cell hepatitis

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Electron microscopic studies of peripheral blood mononuclear cells in chronic type C hepatitis treated with interferon-alpha

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