(Q40030209)

16 September 2017

title

ECRG2 disruption leads to centrosome amplification and spindle checkpoint defects contributing chromosome instability (English)

1 reference

16 September 2017

Xiaolong Cheng

1

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16 September 2017

Zheng Shen

2

1 reference

16 September 2017

Jianyi Yang

3

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16 September 2017

Shih-Hsin Lu

4

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16 September 2017

Yongping Cui

5

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16 September 2017

language of work or name

English

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publication date

27 December 2007

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Journal of Biological Chemistry

16 September 2017

published in

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16 September 2017

volume

283

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16 September 2017

issue

9

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16 September 2017

page(s)

5888-5898

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Mechanisms of chromosome instability in cancers

16 September 2017

cites work

1 reference

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Centrosome biogenesis and function: centrosomics brings new understanding

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Centrosome abnormalities are frequently observed in non-small-cell lung cancer and are associated with aneuploidy and cyclin E overexpression

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Centrosomes and tumour suppressors

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Centrosome amplification, chromosome instability and cancer development

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Mortalin controls centrosome duplication via modulating centrosomal localization of p53.

21 January 2018

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Overexpression of polo-like kinase 1 (PLK1) and chromosomal instability in bladder cancer

21 January 2018

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Plk4-induced centriole biogenesis in human cells

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Revisiting the role of the mother centriole in centriole biogenesis.

21 January 2018

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Aurora a and B overexpression and centrosome amplification in early estrogen-induced tumor foci in the Syrian hamster kidney: implications for chromosomal instability, aneuploidy, and neoplasia.

21 January 2018

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Preventing the degradation of mps1 at centrosomes is sufficient to cause centrosome reduplication in human cells

21 January 2018

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Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression

21 January 2018

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Cell biology: the checkpoint brake relieved.

21 January 2018

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Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation

21 January 2018

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Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities

21 January 2018

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Flies without a spindle checkpoint

21 January 2018

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Structural analysis of Bub3 interactions in the mitotic spindle checkpoint

21 January 2018

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Chemical genetics reveals a role for Mps1 kinase in kinetochore attachment during mitosis

21 January 2018

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Spindle regulation: Mps1 flies into new areas

21 January 2018

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Ablation of the spindle assembly checkpoint by a compound targeting Mps1.

21 January 2018

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Monoclonal antibodies to esophageal cancer-related gene2 protein.

21 January 2018

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ECRG2, a novel candidate of tumor suppressor gene in the esophageal carcinoma, interacts directly with metallothionein 2A and links to apoptosis

21 January 2018

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ECRG2 inhibits cancer cell migration, invasion and metastasis through the down-regulation of uPA/plasmin activity

21 January 2018

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Centrioles: duplicating precariously.

21 January 2018

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Mechanism limiting centrosome duplication to once per cell cycle

21 January 2018

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Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway

21 January 2018

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The p53 tumor suppressor participates in multiple cell cycle checkpoints

21 January 2018

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Loss of p53 and centrosome hyperamplification.

21 January 2018

1 reference

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p21(Waf1/Cip1) deficiency stimulates centriole overduplication

21 January 2018

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The spindle-assembly checkpoint in space and time

21 January 2018

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Overexpression of BUBR1 is associated with chromosomal instability in bladder cancer.

21 January 2018

1 reference

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Transcriptional control of BubR1 by p53 and suppression of centrosome amplification by BubR1

21 January 2018

1 reference

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p53 activation in response to mitotic spindle damage requires signaling via BubR1-mediated phosphorylation.

21 January 2018

1 reference

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Centrosome function in normal and tumor cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M708145200

1 reference

16 September 2017

1 reference