(Q40064969)

17 September 2017

title

In silico pathway analysis: the final frontier towards completely rational drug design (English)

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17 September 2017

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Anton Yuryev

1

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17 September 2017

language of work or name

English

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publication date

1 August 2008

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Expert Opinion on Drug Discovery

17 September 2017

published in

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17 September 2017

volume

3

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17 September 2017

issue

8

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17 September 2017

page(s)

867-876

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Human disease classification in the postgenomic era: a complex systems approach to human pathobiology

17 September 2017

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Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model

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A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration

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Targeted disruption of glycerol kinase gene in mice: expression analysis in liver shows alterations in network partners related to glycerol kinase activity

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Epithelial to mesenchymal transition in human breast epithelial cells transformed by 17beta-estradiol

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A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging

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Automatic extraction of gene ontology annotation and its correlation with clusters in protein networks

21 January 2018

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21 January 2018

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Large-scale mapping of human protein-protein interactions by mass spectrometry

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Extracting human protein interactions from MEDLINE using a full-sentence parser

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Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance

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Parathyroid tumor development involves deregulation of homeobox genes

21 January 2018

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A comprehensive pathway map of epidermal growth factor receptor signaling

21 January 2018

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A comprehensive map of the toll-like receptor signaling network

21 January 2018

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Formation of regulatory patterns during signal propagation in a Mammalian cellular network

21 January 2018

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Regulatory network of inflammation downstream of proteinase-activated receptors

21 January 2018

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Pathway analysis software as a tool for drug target selection, prioritization and validation of drug mechanism

21 January 2018

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21 January 2018

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21 January 2018

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Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties

21 January 2018

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Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein

21 January 2018

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21 January 2018

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Interlinked fast and slow positive feedback loops drive reliable cell decisions

21 January 2018

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The CCAAT box-binding factor stimulates ammonium assimilation in Saccharomyces cerevisiae, defining a new cross-pathway regulation between nitrogen and carbon metabolisms.

21 January 2018

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Duplication-divergence model of protein interaction network.

21 January 2018

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Applied information retrieval and multidisciplinary research: new mechanistic hypotheses in complex regional pain syndrome

21 January 2018

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Genomic expression profiling of human inflammatory cardiomyopathy (DCMi) suggests novel therapeutic targets.

21 January 2018

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Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target

21 January 2018

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Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Molecular portrait of the progestagenic and estrogenic actions of tibolone: behavior of cellular networks in response to tibolone

21 January 2018

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Interplay of genes regulated by estrogen and diindolylmethane in breast cancer cell lines

21 January 2018

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Tamoxifen treatment for breast cancer enforces a distinct gene-expression profile on the human endometrium: an exploratory study

21 January 2018

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The contribution of methotrexate exposure and host factors on transcriptional variance in human liver

21 January 2018

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Exposure to arsenic at levels found inU.S. drinking water modifies expression in the mouse lung.

21 January 2018

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Underlying mechanisms of pharmacology and toxicity of a novel PPAR agonist revealed using rodent and canine hepatocytes.

21 January 2018

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Testicular gene expression profiling following prepubertal rat mono-(2-ethylhexyl) phthalate exposure suggests a common initial genetic response at fetal and prepubertal ages

21 January 2018

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Coxibs and cardiovascular disease

21 January 2018

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Promiscuous drugs compared to selective drugs (promiscuity can be a virtue)

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.3.8.867

21 January 2018

Identifiers

DOI

10.1517/17460441.3.8.867

1 reference

17 September 2017

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