(Q40086335)

English

Antiproliferative effects and mechanism of action of ICI 195,739, a novel bis-triazole derivative, on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi

scientific article published on April 1991

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Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

Antiproliferative effects and mechanism of action of ICI 195,739, a novel bis-triazole derivative, on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi (English)

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

Trypanosoma cruzi

0 references

1 reference

based on heuristic

inferred from title

author name string

Urbina JA

1

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

Lazardi K

2

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

Aguirre T

3

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

Piras MM

4

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

Piras R

5

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

language of work or name

0 references

publication date

1 April 1991

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

number of pages

6

1 reference

based on heuristic

inferred from page(s)

Antimicrobial Agents and Chemotherapy

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

35

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

4

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

730-735

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=245087

22 September 2017

Sterol structure and membrane function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=245087

22 September 2017

In vitro and in vivo effects of the antimycotic drug ketoconazole on sterol synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=245087

22 September 2017

Specific inhibition of fungal sterol biosynthesis by SF 86-327, a new allylamine antimycotic agent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=245087

22 September 2017

Sterols of ketoconazole-inhibited Leishmania mexicana mexicana promastigotes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=245087

22 September 2017

Inhibition of squalene epoxidase by allylamine antimycotic compounds. A comparative study of the fungal and mammalian enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=245087

22 September 2017

Antiproliferative synergism of the allylamine SF 86-327 and ketoconazole on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=245087

22 September 2017

Perturbation of sterol biosynthesis by itraconazole and ketoconazole in Leishmania mexicana mexicana infected macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=245087

22 September 2017

The activity of ketoconazole and other azoles against Trypanosoma cruzi: biochemistry and chemotherapeutic action in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=245087

22 September 2017

Ultrastructural alterations induced by two ergosterol biosynthesis inhibitors, ketoconazole and terbinafine, on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=245087

22 September 2017

Ultrastructural alterations induced by ICI 195,739, a bis-triazole derivative with strong antiproliferative action against Trypanosoma (Schizotrypanum) cruzi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=245087

22 September 2017

Antimycotic imidazoles. Part 4. Synthesis and antifungal activity of ketoconazole, a new potent orally active broad-spectrum antifungal agent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=245087

22 September 2017

The functional importance of structural features of ergosterol in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=245087

25 September 2017

Biochemical effects of miconazole on fungi. II. Inhibition of ergosterol biosynthesis in Candida albicans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=245087

25 September 2017

Ketoconazole Inhibition of Intracellular Multiplication of Trypanosoma cruzi and Protection of Mice Against Lethal Infection with the Organism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=245087

15 June 2018

Effect of allylamine antimycotic agents on fungal sterol biosynthesis measured by sterol side-chain methylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=245087

15 June 2018

Activity of ICI 195,739--a novel, orally active bistriazole--in rodent models of fungal and protozoal infections

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=245087

15 June 2018

Ketoconazole promotes parasitological cure of mice infected with Trypanosoma cruzi.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=245087

15 June 2018

Mode of action studies. Basis for the search of new antifungal drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=245087

15 June 2018

Alteration of lipid order profile and permeability of plasma membranes from Trypanosoma cruzi epimastigotes grown in the presence of ketoconazole

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=245087

15 June 2018

Ketoconazole and other potent antimycotic azoles exhibit pronounced activity against Trypanosoma cruzi, Plasmodium berghei and Entamoeba histolytica in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=245087

20 August 2018

Activity of imidazoles against Leishmania tropica in human macrophage cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=245087

20 August 2018

Design and evaluation of a systemically active agent, fluconazole

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=245087

20 August 2018

In vitro and in vivo effects of itraconazole against Trypanosoma cruzi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=245087

2 December 2018

Evidence for facilitated transport in the absorption of sterols by Saccharomyces cerevisiae

1 reference

https://pubmed.ncbi.nlm.nih.gov/2069379

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of ketoconazole on sterol biosynthesis by Trypanosoma cruzi epimastigotes

1 reference

https://pubmed.ncbi.nlm.nih.gov/2069379

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of ketoconazole on sterol biosynthesis by Leishmania mexicana mexicana amastigotes in murine macrophage tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/2069379

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A clinical trial of itraconazole in the treatment of deep mycoses and leishmaniasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/2069379

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of antimycotic azoles on growth and sterol biosynthesis of Leishmania promastigotes

1 reference

https://pubmed.ncbi.nlm.nih.gov/2069379

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of action of the antimycotic imidazoles

1 reference

https://pubmed.ncbi.nlm.nih.gov/2069379

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical and ultrastructural alterations produced by miconazole and econazole in Trypanosoma cruzi

1 reference

https://pubmed.ncbi.nlm.nih.gov/2069379

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral Ketoconazole in the Treatment of Leishmaniasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/2069379

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of ketoconazole on growth and sterol biosynthesis of Leishmania mexicana promastigotes in culture☆

1 reference

https://pubmed.ncbi.nlm.nih.gov/2069379

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trypanosoma (Schizotrypanum) cruzi: terminal oxidases in exponential and stationary growth phase emipastigotes cultured in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/2069379

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical studies with a novel antifungal agent, ICI 195,739

1 reference

https://pubmed.ncbi.nlm.nih.gov/2069379

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro potency and in vivo activity of azoles

1 reference

https://pubmed.ncbi.nlm.nih.gov/2069379

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and structure-activity relationships of a novel antifungal agent, ICI 195,739

1 reference

https://pubmed.ncbi.nlm.nih.gov/2069379

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Concentration and time dependence of the effects of ketoconazole on growth and sterol synthesis by Trypanosoma (Schizotrypanum) cruzi epimastigotes

1 reference

https://pubmed.ncbi.nlm.nih.gov/2069379

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/AAC.35.4.730

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

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