(Q40098611)

17 September 2017

title

Identification of acidic amino acid residues in the protein kinase C alpha V5 domain that contribute to its insensitivity to diacylglycerol (English)

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17 September 2017

Helena Stensman

1

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17 September 2017

Christer Larsson

series ordinal

2

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17 September 2017

language of work or name

English

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publication date

2 August 2007

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Journal of Biological Chemistry

17 September 2017

published in

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17 September 2017

volume

282

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17 September 2017

issue

39

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17 September 2017

page(s)

28627-28638

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Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C

17 September 2017

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C1 domains exposed: from diacylglycerol binding to protein-protein interactions

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Protein kinase C binding partners

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Green fluorescent protein (GFP)-tagged cysteine-rich domains from protein kinase C as fluorescent indicators for diacylglycerol signaling in living cells

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The catalytic domain limits the translocation of protein kinase C alpha in response to increases in Ca2+ and diacylglycerol

21 January 2018

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Activation mechanisms of conventional protein kinase C isoforms are determined by the ligand affinity and conformational flexibility of their C1 domains

21 January 2018

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Role of the Ca2+/phosphatidylserine binding region of the C2 domain in the translocation of protein kinase Calpha to the plasma membrane.

21 January 2018

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Ca2+-controlled competitive diacylglycerol binding of protein kinase C isoenzymes in living cells

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Interplay between calcium, diacylglycerol, and phosphorylation in the spatial and temporal regulation of PKCalpha-GFP.

21 January 2018

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A single residue in the C1 domain sensitizes novel protein kinase C isoforms to cellular diacylglycerol production

21 January 2018

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Autophosphorylation suppresses whereas kinase inhibition augments the translocation of protein kinase Calpha in response to diacylglycerol

21 January 2018

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PKCepsilon, via its regulatory domain and independently of its catalytic domain, induces neurite-like processes in neuroblastoma cells

21 January 2018

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Direct binding of syndecan-4 cytoplasmic domain to the catalytic domain of protein kinase C alpha (PKC alpha) increases focal adhesion localization of PKC alpha

21 January 2018

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A new phosphatidylinositol 4,5-bisphosphate-binding site located in the C2 domain of protein kinase Calpha.

21 January 2018

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The C2 domain of PKCalpha is a Ca2+ -dependent PtdIns(4,5)P2 sensing domain: a new insight into an old pathway.

21 January 2018

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Regulation of receptor-mediated protein kinase C membrane trafficking by autophosphorylation

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Roles of ionic residues of the C1 domain in protein kinase C-alpha activation and the origin of phosphatidylserine specificity.

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Analysis by fluorescence resonance energy transfer of the interaction between ligands and protein kinase Cdelta in the intact cell.

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Structure of the catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor

21 January 2018

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A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation

21 January 2018

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The carboxyl terminus of protein kinase c provides a switch to regulate its interaction with the phosphoinositide-dependent kinase, PDK-1.

21 January 2018

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The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C.

21 January 2018

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HSP25 inhibits protein kinase C delta-mediated cell death through direct interaction

21 January 2018

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Binding specificity for RACK1 resides in the V5 region of beta II protein kinase C.

21 January 2018

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Molecular dynamics characterization of the C2 domain of protein kinase Cbeta

21 January 2018

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Specific interaction of the PDZ domain protein PICK1 with the COOH terminus of protein kinase C-alpha

21 January 2018

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A unique PDZ ligand in PKCalpha confers induction of cerebellar long-term synaptic depression

21 January 2018

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Role of the lysine-rich cluster of the C2 domain in the phosphatidylserine-dependent activation of PKCalpha.

21 January 2018

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The ATP-dependent membrane localization of protein kinase Calpha is regulated by Ca2+ influx and phosphatidylinositol 4,5-bisphosphate in differentiated PC12 cells

21 January 2018

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Specific translocation of protein kinase Calpha to the plasma membrane requires both Ca2+ and PIP2 recognition by its C2 domain

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702248200

Diacylglycerol-induced Membrane Targeting and Activation of Protein Kinase Cϵ

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M702248200

1 reference

17 September 2017

1 reference