(Q40105328)

English

The oestrogen metabolite 2-methoxyoestradiol alone or in combination with tumour necrosis factor-related apoptosis-inducing ligand mediates apoptosis in cancerous but not healthy cells of the human endometrium

scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

The oestrogen metabolite 2-methoxyoestradiol alone or in combination with tumour necrosis factor-related apoptosis-inducing ligand mediates apoptosis in cancerous but not healthy cells of the human endometrium (English)

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

apoptotic process

0 references

0 references

1 reference

based on heuristic

inferred from title

6

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

author name string

Sumie Kato

1

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Anil Sadarangani

2

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Soledad Lange

3

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Manuel Villalón

4

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Jorge Brañes

5

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Gareth I Owen

7

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Mauricio Cuello

8

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

publication date

1 June 2007

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Endocrine-Related Cancer

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

14

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

351-368

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Effects of 2-methoxyestradiol on endometrial carcinoma xenografts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

TRAIL mediates apoptosis in cancerous but not normal primary cultured cells of the human reproductive tract

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

Crosstalk between extrinsic and intrinsic cell death pathways in pancreatic cancer: synergistic action of estrogen metabolite and ligands of death receptor family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

Modulation of cell-cycle regulatory signaling network by 2-methoxyestradiol in prostate cancer cells is mediated through multiple signal transduction pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

17Beta-hydroxysteroid dehydrogenase Type 1 and Type 2: association between mRNA expression and activity in cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

2-methoxyestradiol induces cell cycle arrest and mitotic cell apoptosis in human vascular smooth muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

An overview of uterine cancer and its management

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

The potential and suitability of 2-methoxyestradiol in cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

Bax/Bcl-2 expression levels of 2-methoxyestradiol-exposed esophageal cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

Selective insensitivity of ZR-75-1 human breast cancer cells to 2-methoxyestradiol: evidence for type II 17beta-hydroxysteroid dehydrogenase as the underlying cause

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

The effects of 2-methoxyoestrogen sulphamates on the in vitro and in vivo proliferation of breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

The secreted peptidyl prolyl cis,trans-isomerase HP0175 of Helicobacter pylori induces apoptosis of gastric epithelial cells in a TLR4- and apoptosis signal-regulating kinase 1-dependent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

2-Methoxyestradiol induces cell cycle arrest and apoptosis of nasopharyngeal carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

Survival versus apoptotic 17beta-estradiol effect: role of ER alpha and ER beta activated non-genomic signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

Genotoxic metabolites of estradiol in breast: potential mechanism of estradiol induced carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

Propagation in a fluid medium of a human epidermoid carcinoma, strain KB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

2-Methoxyestradiol, a promising anticancer agent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

2-methoxyestradiol up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

The temporal reliability of serum estrogens, progesterone, gonadotropins, SHBG and urinary estrogen and progesterone metabolites in premenopausal women

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

Mechanisms for 2-methoxyestradiol-induced apoptosis of prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

2-Methoxyestradiol overcomes drug resistance in multiple myeloma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors alpha and beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

Epidermal growth factor protects epithelial-derived cells from tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by inhibiting cytochrome c release.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

Abnormal expression of 17beta-hydroxysteroid dehydrogenases in breast cancer predicts late recurrence.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

2-Methoxyestradiol induces G2/M arrest and apoptosis in prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

Synergistic induction of apoptosis by the combination of trail and chemotherapy in chemoresistant ovarian cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

Functional role of estrogen metabolism in target cells: review and perspectives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

Fas expression and function in normal and malignant breast cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

Monoamine oxidase and catecholamine metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

Studies of the growth and cytogenetic properties of human endometrial adenocarcinoma in culture and its development into an established line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

[Establishment of a new human endometrial adenocarcinoma cell line, Ishikawa cells, containing estrogen and progesterone receptors].

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

Binding of 2-hydroxyestradiol and 4-hydroxyestradiol to estrogen receptors from human breast cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

Long-term human breast carcinoma cell lines of metastatic origin: preliminary characterization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

Establishment and characterization of three new continuous cell lines derived from human breast carcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6112420

1 October 2018

Comparative properties of the catechol estrogens, I: methylation by catechol-O-methyltransferase and binding to cytosol estrogen receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17639050

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative pharmacology of oestrogens and catechol oestrogens: actions on the immature rat uterus in vivo and in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/17639050

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endometrial cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17639050

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Superoxide dismutase as a target for the selective killing of cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17639050

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of cytochrome P-450 species which catalyze the hydroxylations of the aromatic ring of estradiol and estradiol 17-sulfate

1 reference

https://pubmed.ncbi.nlm.nih.gov/17639050

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between p53 pathway and estrogen receptor status in endometrioid-type endometrial cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17639050

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-performance liquid chromatography separation of hydroxylated estradiol metabolites: formation of estradiol metabolites by liver microsomes from male and female rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17639050

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible protective effects of alpha-tocopherol on enhanced induction of reactive oxygen species by 2-methoxyestradiol in tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17639050

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1677/ERC-07-0008

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

PMC publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

ResearchGate publication ID

0 references

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