(Q40105829)

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The histone deacetylase inhibitor ITF2357 has anti-leukemic activity in vitro and in vivo and inhibits IL-6 and VEGF production by stromal cells

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Europe PubMed Central

PubMed publication ID

17 September 2017

The histone deacetylase inhibitor ITF2357 has anti-leukemic activity in vitro and in vivo and inhibits IL-6 and VEGF production by stromal cells (English)

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Europe PubMed Central

PubMed publication ID

17 September 2017

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J Golay

1

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17 September 2017

L Cuppini

2

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17 September 2017

F Leoni

3

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17 September 2017

C Micò

4

1 reference

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17 September 2017

V Barbui

5

1 reference

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17 September 2017

M Domenghini

6

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17 September 2017

L Lombardi

7

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17 September 2017

A Neri

8

1 reference

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17 September 2017

A M Barbui

9

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17 September 2017

A Salvi

10

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17 September 2017

P Pozzi

11

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17 September 2017

G Porro

12

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17 September 2017

P Pagani

13

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Europe PubMed Central

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17 September 2017

G Fossati

14

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17 September 2017

P Mascagni

15

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17 September 2017

M Introna

16

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17 September 2017

A Rambaldi

17

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17 September 2017

publication date

19 July 2007

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17 September 2017

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17 September 2017

21

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17 September 2017

9

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17 September 2017

1892-1900

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17 September 2017

Histone deacetylases (HDACs): characterization of the classical HDAC family

1 reference

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Epigenetic aspects of differentiation

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Anticancer activities of histone deacetylase inhibitors

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Prospects: histone deacetylase inhibitors

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Drug insight: Histone deacetylase inhibitors--development of the new targeted anticancer agent suberoylanilide hydroxamic acid

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Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug

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Clinical experience with intravenous and oral formulations of the novel histone deacetylase inhibitor suberoylanilide hydroxamic acid in patients with advanced hematologic malignancies

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The molecular pathogenesis of acute myeloid leukemia

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Retinoid receptors in health and disease: co-regulators and the chromatin connection

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Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3.

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Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway

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Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells

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Histone deacetylase inhibitor NVP-LAQ824 has significant activity against myeloid leukemia cells in vitro and in vivo

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Will broad-spectrum histone deacetylase inhibitors be superseded by more specific compounds?

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Multiple myeloma

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The pathophysiologic role of VEGF in hematologic malignancies: therapeutic implications

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SDX-101, the R-enantiomer of etodolac, induces cytotoxicity, overcomes drug resistance, and enhances the activity of dexamethasone in multiple myeloma

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Tipifarnib and bortezomib are synergistic and overcome cell adhesion-mediated drug resistance in multiple myeloma and acute myeloid leukemia

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Zoledronic acid down-regulates adhesion molecules of bone marrow stromal cells in multiple myeloma: a possible mechanism for its antitumor effect.

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The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo

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Apoptosis on hepatoma cells but not on primary hepatocytes by histone deacetylase inhibitors valproate and ITF2357.

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HDAC inhibitor treatment of hepatoma cells induces both TRAIL-independent apoptosis and restoration of sensitivity to TRAIL.

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The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines

1 reference

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Histone deacetylase inhibitors prevent exocytosis of interleukin-1beta-containing secretory lysosomes: role of microtubules

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Multilineage potential of adult human mesenchymal stem cells

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Establishment of human acute myelogenous leukemia lines secreting interleukin-1β in SCID mice

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Gemtuzumab ozogamicin (Mylotarg) has therapeutic activity against CD33 acute lymphoblastic leukaemias in vitro and in vivo.

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Cotreatment with histone deacetylase inhibitor LAQ824 enhances Apo-2L/tumor necrosis factor-related apoptosis inducing ligand-induced death inducing signaling complex activity and apoptosis of human acute leukemia cells

1 reference

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The histone deacetylase inhibitor LBH589 is a potent antimyeloma agent that overcomes drug resistance.

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Histone deacetylase inhibitors: insights into mechanisms of lethality

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Histone deacetylase (HDAC) inhibitor activation of p21WAF1 involves changes in promoter-associated proteins, including HDAC1

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Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors.

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Analysis of histone deacetylase inhibitor, depsipeptide (FR901228), effect on multiple myeloma

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Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma

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ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression

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Differential protein acetylation induced by novel histone deacetylase inhibitors

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Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells

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Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma

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CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma.

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NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma

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Targeting receptor kinases by a novel indolinone derivative in multiple myeloma: abrogation of stroma-derived interleukin-6 secretion and induction of apoptosis in cytogenetically defined subgroups

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Human mesenchymal stem cells modulate allogeneic immune cell responses

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Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-gamma

1 reference

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Histone deacetylase inhibitors have antitumor activity in two NOD/SCID mouse models of B-cell precursor childhood acute lymphoblastic leukemia

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10.1038/SJ.LEU.2404860

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

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