(Q40112219)

17 September 2017

Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes (English)

1 reference

17 September 2017

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Elisabeth Christiansen

1

1 reference

17 September 2017

Steffen V F Hansen

2

1 reference

17 September 2017

Christian Urban

3

1 reference

17 September 2017

Brian D Hudson

4

1 reference

17 September 2017

Edward T Wargent

5

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17 September 2017

Manuel Grundmann

6

1 reference

17 September 2017

Laura Jenkins

7

1 reference

17 September 2017

Mohamed Zaibi

8

1 reference

17 September 2017

Claire J Stocker

9

1 reference

17 September 2017

Susanne Ullrich

10

1 reference

17 September 2017

Evi Kostenis

11

1 reference

17 September 2017

Matthias U Kassack

12

1 reference

17 September 2017

Graeme Milligan

13

1 reference

17 September 2017

Michael A Cawthorne

14

1 reference

17 September 2017

Trond Ulven

15

1 reference

17 September 2017

8 April 2013

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ACS Medicinal Chemistry Letters

17 September 2017

1 reference

17 September 2017

4

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17 September 2017

5

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17 September 2017

441-445

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Structure-Activity Study of Dihydrocinnamic Acids and Discovery of the Potent FFA1 (GPR40) Agonist TUG-469.

17 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3654565

Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3654565

Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3654565

G protein-coupled receptors for energy metabolites as new therapeutic targets

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3654565

Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3654565

Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3654565

Ligand efficiency: a useful metric for lead selection

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3654565

Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3654565

A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3654565

The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3654565

Free fatty acid receptor 1 (FFA1/GPR40) agonists: mesylpropoxy appendage lowers lipophilicity and improves ADME properties

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3654565

Drug discovery opportunities and challenges at g protein coupled receptors for long chain free Fatty acids

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3654565

Discovery of a potent and selective GPR120 agonist.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3654565

Design, synthesis, and biological activity of potent and orally available G protein-coupled receptor 40 agonists

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3654565

A rapid and efficient Sonogashira protocol and improved synthesis of free fatty acid 1 (FFA1) receptor agonists

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3654565

The influence of drug-like concepts on decision-making in medicinal chemistry

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3654565

TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial

20 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23687558

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ML4000673

1 reference

17 September 2017

1 reference

17 September 2017

PubMed publication ID

23687558

1 reference