(Q40119087)

17 September 2017

title

Knock down of gamma-glutamylcysteine synthetase in rat causes acetaminophen-induced hepatotoxicity (English)

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17 September 2017

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Sho Akai

1

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17 September 2017

Hiroko Hosomi

2

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17 September 2017

Keiichi Minami

3

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17 September 2017

Koichi Tsuneyama

4

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17 September 2017

Miki Katoh

5

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17 September 2017

Miki Nakajima

6

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17 September 2017

Tsuyoshi Yokoi

7

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17 September 2017

language of work or name

English

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publication date

15 June 2007

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Journal of Biological Chemistry

17 September 2017

published in

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17 September 2017

volume

282

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17 September 2017

issue

33

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17 September 2017

page(s)

23996-24003

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Regulation of reductive processes by glutathione

17 September 2017

cites work

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Glutathione synthesis is essential for mouse development but not for cell growth in culture

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Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response

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Current status of gendicine in China: recombinant human Ad-p53 agent for treatment of cancers

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21 January 2018

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Hepatic knockdown of mitochondrial GPAT1 in ob/ob mice improves metabolic profile

21 January 2018

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Trifluoperazine inhibits insulin action on glucose metabolism in fat cells without affecting inhibition of lipolysis

21 January 2018

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Conjugations with glutathione. Distribution of glutathione S-aryltransferase in vertebrate species

21 January 2018

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Impact of the coxsackie and adenovirus receptor (CAR) on glioma cell growth and invasion: requirement for the C-terminal domain

21 January 2018

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Evidence for the involvement of N-acetyl-p- quinoneimine in acetaminophen metabolism

21 January 2018

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Cytochrome P-450-mediated oxidation of substrates by electron-transfer; role of oxygen radicals and of 1- and 2-electron oxidation of paracetamol

21 January 2018

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Impact of transgene expression on drug metabolism following systemic adenoviral vector administration

21 January 2018

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Alterations in the rat serum proteome during liver injury from acetaminophen exposure

21 January 2018

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Additive effects of inducers and fasting on acetaminophen hepatotoxicity.

21 January 2018

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Transcriptional control of CYP2E1 in the perivenous liver region and during starvation.

21 January 2018

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In vivo hepatotoxicity study of rats in comparison with in vitro hepatotoxicity screening system

21 January 2018

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Oxidative stress and Mrp2 internalization

21 January 2018

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Intrahepatic injection of adenovirus reduces inflammation and increases gene transfer and therapeutic effect in mice

21 January 2018

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In vitro methods to study chemically-induced hepatotoxicity: a literature review

21 January 2018

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Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M702819200

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17 September 2017

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