(Q40123566)

17 September 2017

Opioid receptor pharmacological chaperones act by binding and stabilizing newly synthesized receptors in the endoplasmic reticulum (English)

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17 September 2017

endoplasmic reticulum

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molecular chaperones

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author name string

Tarja T Leskelä

1

1 reference

17 September 2017

Piia M H Markkanen

2

1 reference

17 September 2017

E Maritta Pietilä

3

1 reference

17 September 2017

Jussi T Tuusa

4

1 reference

17 September 2017

Ulla E Petäjä-Repo

5

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17 September 2017

language of work or name

English

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publication date

5 June 2007

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Journal of Biological Chemistry

17 September 2017

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17 September 2017

282

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17 September 2017

32

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17 September 2017

23171-23183

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Quality control in the endoplasmic reticulum

17 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

ERAD: the long road to destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Mutant G-protein-coupled receptors as a cause of human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Reconstitution of mutant V2 vasopressin receptors by adenovirus-mediated gene transfer. Molecular basis and clinical implication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Functional rescue of the nephrogenic diabetes insipidus-causing vasopressin V2 receptor mutants G185C and R202C by a second site suppressor mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Molecular basis of hypogonadotropic hypogonadism: restoration of mutant (E(90)K) GnRH receptor function by a deletion at a distant site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Pharmacological chaperones: a new twist on receptor folding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Pharmacological chaperones: potential treatment for conformational diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Pharmacologic rescue of conformationally-defective proteins: implications for the treatment of human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Appropriate polarization following pharmacological rescue of V2 vasopressin receptors encoded by X-linked nephrogenic diabetes insipidus alleles involves a conformation of the receptor that also attains mature glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Functional rescue of the constitutively internalized V2 vasopressin receptor mutant R137H by the pharmacological chaperone action of SR49059.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Rescue of vasopressin V2 receptor mutants by chemical chaperones: specificity and mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Pharmacological chaperone-mediated in vivo folding and stabilization of the P23H-opsin mutant associated with autosomal dominant retinitis pigmentosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Retinoids assist the cellular folding of the autosomal dominant retinitis pigmentosa opsin mutant P23H.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

A point mutation in the human melanin concentrating hormone receptor 1 reveals an important domain for cellular trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Ligands act as pharmacological chaperones and increase the efficiency of delta opioid receptor maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Pharmacochaperones post-translationally enhance cell surface expression by increasing conformational stability of wild-type and mutant vasopressin V2 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Folding efficiency is rate-limiting in dopamine D4 receptor biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Ligands regulate cell surface level of the human kappa opioid receptor by activation-induced down-regulation and pharmacological chaperone-mediated enhancement: differential effects of nonpeptide and peptide agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

A nonpeptide antagonist reveals a highly glycosylated state of the rabbit kinin B1 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Pharmacological chaperone action on G-protein-coupled receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Export from the endoplasmic reticulum represents the limiting step in the maturation and cell surface expression of the human delta opioid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Inefficient maturation of the rat luteinizing hormone receptor. A putative way to regulate receptor numbers at the cell surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Luteinizing hormone receptor ectodomain splice variant misroutes the full-length receptor into a subcompartment of the endoplasmic reticulum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Newly synthesized human delta opioid receptors retained in the endoplasmic reticulum are retrotranslocated to the cytosol, deglycosylated, ubiquitinated, and degraded by the proteasome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Distinct subcellular localization for constitutive and agonist-modulated palmitoylation of the human delta opioid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Brefeldin A redistributes resident and itinerant Golgi proteins to the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Ligand-induced overexpression of a constitutively active beta2-adrenergic receptor: pharmacological creation of a phenotype in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Constitutive activation of the mu opioid receptor by mutation of D3.49(164), but not D3.32(147): D3.49(164) is critical for stabilization of the inactive form of the receptor and for its expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Association of calnexin with wild type and mutant AVPR2 that causes nephrogenic diabetes insipidus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Rescuing the traffic-deficient mutants of rat mu-opioid receptors with hydrophobic ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Mechanisms of cell-surface rerouting of an endoplasmic reticulum-retained mutant of the vasopressin V1b/V3 receptor by a pharmacological chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Cell-type specific targeting of the alpha 2c-adrenoceptor. Evidence for the organization of receptor microdomains during neuronal differentiation of PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

A transmembrane intracellular estrogen receptor mediates rapid cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Regulation of receptor function by cholesterol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Thermodynamic measurements of the contributions of helix-connecting loops and of retinal to the stability of bacteriorhodopsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Effect of nucleotides on the thermal stability and on the deuteration kinetics of the thermophilic F0F1 ATP synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Protein stability induced by ligand binding correlates with changes in protein flexibility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Expression of the mature luteinizing hormone receptor in rodent urogenital and adrenal tissues is developmentally regulated at a posttranslational level.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

Pharmacologic chaperones as a potential treatment for X-linked nephrogenic diabetes insipidus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610896200

21 January 2018

Identifiers

DOI

10.1074/JBC.M610896200

1 reference

17 September 2017

1 reference