(Q40164017)

18 September 2017

1 reference

title

Phenytoin: basic and clinical pharmacology (English)

1 reference

18 September 2017

Phenytoin: Basic and clinical pharmacology (English)

1 reference

https://api.crossref.org/works/10.1002/MED.2610030403

7 October 2023

1 reference

1 reference

1 reference

https://api.crossref.org/works/10.1002/MED.2610030403

7 October 2023

author name string

G. L. Jones

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6358722

7 October 2023

G. H. Wimbish

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6358722

7 October 2023

W. E. McIntosh

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6358722

7 October 2023

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=6358722

7 October 2023

publication date

1 October 1983

1 reference

full work available at URL

18 September 2017

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmed.2610030403

1 reference

https://api.crossref.org/works/10.1002/MED.2610030403

https://onlinelibrary.wiley.com/doi/full/10.1002/med.2610030403

7 October 2023

1 reference

https://api.crossref.org/works/10.1002/MED.2610030403

Medicinal Research Reviews

7 October 2023

published in

1 reference

18 September 2017

volume

3

1 reference

18 September 2017

issue

4

1 reference

18 September 2017

page(s)

383-434

1 reference

The Membrane Binding of Morphine, Diphenylhydantoin, and Tetrahydrocannabinol

18 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1002%2FMED.2610030403

Interaction between phenytoin and antacids

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMED.2610030403

Failure of antacids to alter the pharmacokinetics of phenytoin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMED.2610030403

Effect of Calcium and Antacids on Phenytoin Bioavailability

21 January 2018

1 reference

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Pediatric clinical pharmacology. A practical review

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMED.2610030403

Effect of age, height, weight and sex on serum phenytoin concentration in epileptic patients

21 January 2018

1 reference

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Influence of dietary protein and carbohydrate on phenytoin metabolism in man

21 January 2018

1 reference

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Plasma Albumin Concentration and Diphenylhydantoin Binding in Man

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMED.2610030403

Impaired plasma protein binding of phenytoin in uremia and displacement effect of salicylic acid

21 January 2018

1 reference

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Plasma protein binding interaction between phenytoin and valproic acid in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMED.2610030403

Plasma protein binding of diphenylhydantoin. Effects of sex hormones, renal and hepatic disease

21 January 2018

1 reference

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DIPHENYLHYDANTOIN METABOLISM, BLOOD LEVELS, AND TOXICITY.

21 January 2018

1 reference

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Alteration of plasma albumin in relation to decreased drug binding in uremia

21 January 2018

1 reference

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Plasma disappearance of transplacentally transferred diphenylhydantoin in the newborn studied by mass fragmentography.

21 January 2018

1 reference

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Diphenylhydantoin intoxication during pregnancy. A chemical study of drug distribution in the albino rat.

21 January 2018

1 reference

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Brain Uptake of Phenytoin, Phenobarbital, and Diazepam

21 January 2018

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Microassay of diphenylhydantoin: Blood and regional brain concentrations in rats during acute intoxication

21 January 2018

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Anticonvulsant drugs in human epileptogenic brain. Correlation of phenobarbital and diphenylhydantoin levels with plasma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMED.2610030403

Human brain, cerebrospinal fluid, and plasma concentrations of diphenylhydantoin and phenobarbital

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMED.2610030403

Human epileptic brain Na, K ATPase activity and phenytoin concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMED.2610030403

Interaction of Diphenylhydantoin-4-14C with Subcellular Fractions of Rat Brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMED.2610030403

The renal handling of diphenylhydantoin and 5-(p-hydroxyphenyl)-5-phenylhydantoin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMED.2610030403

Metabolism of diphenylhydantoin (phenytoin) during pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMED.2610030403

Inhibition of phenytoin metabolism by sulthiame in epileptic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMED.2610030403

Diphenylhydantoin and calcium movement in lobster nerves.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMED.2610030403

Diphenylhydantoin and calcium. Relation to norepinephrine release from brain slices.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMED.2610030403

Anticonvulsant drug mechanisms. Phenytoin, phenobarbital, and ethosuximide and calcium flux in isolated presynaptic endings

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMED.2610030403

Inhibition of Antidiuretic Hormone Secretion by Diphenylhydantoin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMED.2610030403

Effect of diphenylhydantoin on synaptosome sodium-potassium-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMED.2610030403

The effect of diphenylhydantoin administration on sodium-potassium-activated ATPase in cortex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMED.2610030403

Effects of anticonvulsant and convulsant drugs on the ATPase activities of synaptosomes and their components

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMED.2610030403

The effects of diphenylhydantoin and potassium on the biological activity of ouabain in the guinea-pig heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMED.2610030403

Depolarization and calcium entry in squid giant axons

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMED.2610030403

Peripheral neuropathy in long-term diphenylhydantoin therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMED.2610030403

Drug-associated blood dyscrasias. Recent additions to the Registry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMED.2610030403

Rapid diagnosis of drug-induced thrombocytopenic purpura. Report of three cases due to quinine, quinidine, and Dilantin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMED.2610030403

DIAGNOSTICALLY CONFUSING COMPLICATIONS OF DIPHENYLHYDANTOIN THERAPY. A REVIEW.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMED.2610030403

Lipid Solubility and Drug Penetration of the Blood Brain Barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMED.2610030403

Über die Konstitution der Einwirkungsprodukte von substituierten Harnstoffen auf Benzil und über einige neue Methoden zur Darstellung der 5.5-Diphenyl-hydantoine

21 January 2018

5

1 reference

https://api.crossref.org/works/10.1002/MED.2610030403

Clinical pharmacology of mephenytoin and ethotoin

7 October 2023

7

1 reference

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Solubility and Ionization Characteristics of Phenytoin

7 October 2023

8

1 reference

https://api.crossref.org/works/10.1002/MED.2610030403

Journal of Pharmacology and Experimental Therapeutics

7 October 2023

9

118

270

Dill

1956

1 reference

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Determination of the pKa' Value for 5,5-Diphenylhydantoin

7 October 2023

10

1 reference

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Uptake and distribution of diphenylthiohydantion (DPTH)

7 October 2023

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7 October 2023

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Properties of maximal seizures, and their alteration by anticonvulant drugs and other agents

7 October 2023

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Diphenylhydantoin and Diazepam: Molecular Structure Similarities and Steric Basis of Anticonvulsant Activity

7 October 2023

23

1 reference

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Stereochemical basis of anticonvulsant drug action. II. Molecular structure of diazepam

7 October 2023

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7 October 2023

Molecular Pharmacology

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The stereochemical basis of anticonvulsant drug action. IV. The crystal and molecular structure of trihexyphenidyl

7 October 2023

27

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Ethylphenacemide and phenacemide: conformational similarities to diphenylhydantoin and stereochemical basis of anticonvulsant activity

7 October 2023

28

1 reference

https://api.crossref.org/works/10.1002/MED.2610030403

Some anticonvulsant, skeletal muscle relaxing, and toxic properties of a series of substituted cyclohexanones

7 October 2023

34

1 reference

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Parabolic dependence of drug action upon lipophilic character as revealed by a study of hypnotics

7 October 2023

36

1 reference

https://api.crossref.org/works/10.1002/MED.2610030403

Electronic factors in the structure-activity relationship of some 1,4-benzodiazepin-2-ones

7 October 2023

37

1 reference

https://api.crossref.org/works/10.1002/MED.2610030403

Structure-activity correlations for anticonvulsant drugs

7 October 2023

38

1 reference

https://api.crossref.org/works/10.1002/MED.2610030403

Quantitative Structure-Activity Relationships and Dipole Moments of Anticonvulsants and CNS Depressants

7 October 2023

39

1 reference

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Clinical significance of generic inequivalence of three different pharmaceutical preparations of phenytoin

7 October 2023

40

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Letter: Bioavailability of phenytoin

7 October 2023

43

1 reference

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Bioavailability of phenytoin. A comparison of two preparations

7 October 2023

46

1 reference

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Effect of dose on phenytoin absorption

7 October 2023

48

1 reference

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Interactions of Antiepileptic Drugs

7 October 2023

51

1 reference

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Effect of calcium and antacids on phenytoin bioavailability

7 October 2023

53

1 reference

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Bioavailability of phenytoin: clinical pharmacokinetic and therapeutic implications

7 October 2023

54

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Some Causes of Ineffectiveness of Diphenylhydantoin

7 October 2023

55

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Effects of Age, Sex, Obesity, and Pregnancy on Plasma Diphenylhydantoin Levels

7 October 2023

60

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Influence of food on the absorption of phenytoin in man

7 October 2023

61

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Age differences in drug binding by plasma proteins: Studies on human foetuses, neonates and adults

7 October 2023

64

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Lack of relationship between serum free fatty acids and impaired plasma protein binding of diphenylhydantoin in chronic renal failure

7 October 2023

70

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Drug interaction: diazoxide and diphenylhydantoin

7 October 2023

71

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Clinical Pharmacology & Therapeutics

7 October 2023

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Decreased drug binding in serum from patients with chronic hepatic disease

7 October 2023

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Influence of disease on binding of drugs to plasma proteins

7 October 2023

76

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Diphenylhydantoin Metabolism in Uremia

7 October 2023

77

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Phenytoin binding to partially purified albumin in renal disease

7 October 2023

79

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Plasma Protein Binding of Phenytoin and Warfarin in Patients Undergoing Renal Transplantation1

7 October 2023

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Decreased serum protein binding of phenytoin in late pregnancy

7 October 2023

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Phenytoin binding in pregnancy

7 October 2023

83

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Serum protein binding of drugs during and after pregnancy in humans.

7 October 2023

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7 October 2023

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7 October 2023

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Brain concentrations of phenytoin, phenobarbitone and primidone in epileptic patients

7 October 2023

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Diphenylhydantoin: Placental transport, fetallocalization, neonatal metabolism, and possible teratogenic effects

7 October 2023

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Antiepileptic drug distribution in cerebral cortex, ammon's horn, and amygdala in man

7 October 2023

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Placental transfer and neonatal elimination of diphenylhydantoin

7 October 2023

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Efficacy of intravenous phenytoin in the treatment of status epilepticus: kinetics of central nervous system penetration

7 October 2023

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Pharmacokinetic profile of diazepam in man following single intravenous and oral and chronic oral administrations.

7 October 2023

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Distribution of 14C-phenytoin in rat Purkinje cells, cerebellar and cerebral neuronal tissue after a single intraperitoneal injection

7 October 2023

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Binding of diphenylhydantoin to brain protein

7 October 2023

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Plasma concentrations of 5-(4-hydroxyphenyl)-5-phenylhydantoin in phenytoin-treated patients

7 October 2023

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Identification of 5-meta-Hydroxyphenyl-5-phenylhydantoin as a metabolite of diphenylhydantoin

7 October 2023

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Predicting Phenytoin Dose—A Revised Nomogram

7 October 2023

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A study of the pharmacokinetics of phenytoin (diphenylhydantoin) in epileptic patients, and the development of a nomogram for making dose increments

7 October 2023

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Clinical Pharmacokinetics of Phenytoin

7 October 2023

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DIPHENYLHYDANTOIN AND PHENOBARBITAL. SERUM LEVELS IN CHILDREN

7 October 2023

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Phenytoin kinetics in children

7 October 2023

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Michaelis-Menten pharmacokinetics of diphenylhydantoin and application in the pediatric age patient

7 October 2023

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Phenytoin elimination in childhood: effect of concentration-dependent kinetics

7 October 2023

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The rate of decline of diphenylhydantoin in human plasma

7 October 2023

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Metabolic disposition of diphenylhydantoin in normal human subiects following intravenous administration

7 October 2023

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Disulfiramum (antabuse) as inhibitor of phenytoin metabolism

7 October 2023

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Dicoumarol-induced diphenylhydantoin intoxication

7 October 2023

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7 October 2023

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Phenytoin intoxication during treatment with antabuse (Disulfiram)

7 October 2023

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The influence of disulfiram and calcium carbimide on the serum diphenylhydantoin. Excretion of HPPH in the urine

7 October 2023

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Sulthiame (Ospolot) as inhibitor of diphenylhydatoin metabolism.

7 October 2023

140

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Carbamazepine-induced acceleration of diphenylhydantoin and warfarin metabolism in man

7 October 2023

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Interaction between phenobarbital and diphenylhydantoin in animals and in epileptic patients.

7 October 2023

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Increased Rate of Clearance of Drugs from the Circulation of Alcoholics*

7 October 2023

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The action of phenytoin on a composite electrical-chemical synapse in the lamprey spinal cord

7 October 2023

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The cellular mode of action of the anti-epileptic drug 5, 5-diphenylhydantoin

7 October 2023

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The mechanism of action of diphenylhydantoin or invertebrate neurons. I. Effects on basic membrane properties

7 October 2023

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7 October 2023

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The mechanism of action of diphenylhydantoin on invertebrate neurons. II. Effects on synaptic mechanisms

7 October 2023

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Diphenylhydantoin: excitability reducing action in single myelinated nerve fibres

7 October 2023

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Effect of diphenylhydantoin on peripheral nerve

7 October 2023

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Diphenylhydantoin: Action of a Common Anticonvulsant on Bursting Pacemaker Cells in Aplysia

7 October 2023

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Inhibition of insulin release by diphenylhydantoin and diazoxide in a patient with benign insulinoma

7 October 2023

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Treatment of acute post-operative inappropriate antidiuretic hormone secretion with diphenylhydantoin.

7 October 2023

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7 October 2023

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Diphenylhydantoin Inhibition of Sodium Conductance in Squid Giant Axon

7 October 2023

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Phenytoin: Effects on Calcium Flux and Cyclic Nucleotides

7 October 2023

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Influence of certain anticonvulsants on the concentration of γ-aminobutyric acid in the cerebral hemispheres of mice

7 October 2023

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Sodium-potassium-activated adenosine triphosphatase of brain microsomes: modification of sodium inhibition by diphenylhydantoins

7 October 2023

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Correlation of antiarrhythmic effects of diphenylhydantoin with digoxin-induced changes in myocardial contractility, sodium-potassium adenosine triphosphatase activity, and potassium efflux

7 October 2023

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The Role or Non-Role of ATPase Activation by Phenytoin in the Stabilization of Excitable Membranes

7 October 2023

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The freezing lesion. III. The effects of diphenylhydantoin on potassium transport within nerve terminals from the primary foci

7 October 2023

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Diphenylhydantoin (Dilantin): stimulation of potassium influx in lobster axons

7 October 2023

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Journal of Pharmacology and Experimental Therapeutics

7 October 2023

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Effects of diphenylhydantoin on transport processes in frog skin (Rana ridibunda)

7 October 2023

191

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Role of pharmacological factors in the evaluation of anticonvulsant drugs

7 October 2023

197

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In vitro inhibition of pancreatic glucagon secretion by diphenylhydantoin.

7 October 2023

198

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Mechanism of inhibition of catecholamine release from adrenal medulla by diphenylhydantoin and by low concentration of ouabain (10?10 M)

7 October 2023

199

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Further study of the role of calcium in synaptic transmission

7 October 2023

200

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Transmitter release induced by injection of calcium ions into nerve terminals.

7 October 2023

201

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Antagonistic action of diphenylhydantoin and calcium on the level of phosphorylation of particular rat and human brain proteins

7 October 2023

202

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Mechanism of action of anticonvulsants: Role of the differential effects on the active uptake of putative neurotransmitters

7 October 2023

203

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Diphenylhydantoin prolongs postsynaptic inhibition and iontophoretic GABA action in the crayfish stretch receptor

7 October 2023

205

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7 October 2023

Molecular Pharmacology

206

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Prolonged inhibition in burst firing neurons: synaptic inactivation of the slow regenerative inward current

7 October 2023

208

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Voltage clamp reveals basis for calcium regulation of bursting pacemaker potentials in Aplysia neurons

7 October 2023

209

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Diphenylhydantoin and ion flux in lobster nerve

7 October 2023

211

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DIPHENYLHYDANTOIN AND PHENOBARBITAL TOXICITY. THE ROLE OF LIVER DISEASE

7 October 2023

214

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Intramuscular administration of phenytoin

7 October 2023

215

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Mental effects of anticonvulsants, and folic acid metabolism

7 October 2023

217

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Studies on the mechanism of action of diphenylhydantoin

7 October 2023

220

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Evidence of osteomalacia in an outpatient group of adult epileptics

7 October 2023

221

1 reference

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Rickets in children receiving anticonvulsant drugs. Biochemical and hormonal markers

7 October 2023

222

1 reference

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Inhibition of intestinal calcium transport by diphenylhydantoin in rat duodenum.

7 October 2023

224

1 reference

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Chronic Antiepileptic Toxicity: A Review

7 October 2023

226

1 reference

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Effect of Diphenylhydantoin on Insulin Secretion in Man

7 October 2023

229

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Oral Diphenylhydantoin in Corneal Wound Healing in the Rabbit

7 October 2023

234

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Control of cutaneous collagenolysis.

7 October 2023

235

1 reference

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Diphenylhydantoin effects on thyroid function tests

7 October 2023

236

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The effect of diphenylhydantoin on thyroid function

7 October 2023

237

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Thyroid hormone levels and protein binding in patients on long-term diphenylhydantoin treatment

7 October 2023

238

1 reference

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Effect of 5,5'-diphenylhydantoin on the metabolism of L-thyroxine-131-I in the rat

7 October 2023

239

1 reference

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Drugs as etiologic factors in the Stevens-Johnson syndrome

7 October 2023

242

1 reference

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DILANTIN-INDUCED SERUM SICKNESS. CASE REPORT AND INQUIRY INTO ITS MECHANISM

7 October 2023

244

1 reference

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Folate metabolism in epileptic and psychiatric patients

7 October 2023

254

1 reference

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Macrocytosis in Patients on Anticonvulsant Drugs

7 October 2023

255

1 reference

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Risks to the offspring of women treated with hydantoin anticonvulsants, with emphasis on the fetal hydantoin syndrome

7 October 2023

257

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7 October 2023

Identifiers

1 reference

18 September 2017

1 reference