(Q40164245)

18 September 2017

title

Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs (English)

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18 September 2017

main subject

endoplasmic reticulum

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P Pirot

1

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18 September 2017

N Naamane

2

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18 September 2017

F Libert

3

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18 September 2017

N E Magnusson

4

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18 September 2017

T F Ørntoft

5

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18 September 2017

A K Cardozo

6

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18 September 2017

D L Eizirik

7

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18 September 2017

publication date

1 March 2007

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18 September 2017

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18 September 2017

volume

50

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18 September 2017

issue

5

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18 September 2017

page(s)

1006-1014

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https://scigraph.springernature.com/pub.10.1007/s00125-007-0609-0

18 September 2017

exact match

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cites work

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The ER function BiP is a master regulator of ER function

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The cytokine interleukin-1beta reduces the docking and fusion of insulin granules in pancreatic beta-cells, preferentially decreasing the first phase of exocytosis

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Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells

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12 December 2020

Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis

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Interferon-gamma potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms

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Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

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12 December 2020

Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.

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12 December 2020

The mammalian unfolded protein response

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12 December 2020

Transcription factors direct the development and function of pancreatic beta cells

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12 December 2020

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress

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12 December 2020

Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells

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12 December 2020

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

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12 December 2020

Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release

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12 December 2020

Role for activating transcription factor 3 in stress-induced beta-cell apoptosis

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12 December 2020

Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis

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12 December 2020

Exendin-4 as a stimulator of rat insulin I gene promoter activity via bZIP/CRE interactions sensitive to serine/threonine protein kinase inhibitor Ro 31-8220.

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12 December 2020

Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-gamma-induced apoptosis in primary pancreatic beta-cells

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12 December 2020

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

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GRP94, an ER chaperone with protein and peptide binding properties

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12 December 2020

Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities

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12 December 2020

Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1.

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12 December 2020

Apoptosis in insulin-secreting cells. Evidence for the role of intracellular Ca2+ stores and arachidonic acid metabolism

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12 December 2020

Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells

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12 December 2020

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

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12 December 2020

Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays

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12 December 2020

New normalization methods for cDNA microarray data

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12 December 2020

Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway

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12 December 2020

Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response

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12 December 2020

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis

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12 December 2020

Statistical significance for genomewide studies

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12 December 2020

The role of prohormone convertases in insulin biosynthesis: evidence for inherited defects in their action in man and experimental animals

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12 December 2020

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

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12 December 2020

Endoplasmic reticulum stress: cell life and death decisions.

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12 December 2020

Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion

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12 December 2020

EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome

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12 December 2020

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

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DNA microarrays and likelihood ratio bioinformatic methods: discovery of human melanocyte biomarkers

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12 December 2020

Interleukin-1β Induces an Early Decrease in Insulin Release, (Pro)Insulin Biosynthesis and Insulin Mrna in Mouse Pancreatic Islets by a Mechanism Dependent on Gene Transcription and Protein Synthesis

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12 December 2020

Effect of interleukin-1 on the biosynthesis of proinsulin and insulin in isolated rat pancreatic islets

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12 December 2020

Construction and validation of the APOCHIP, a spotted oligo-microarray for the study of beta-cell apoptosis

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12 December 2020

Surfing the Sec61 channel: bidirectional protein translocation across the ER membrane.

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12 December 2020

Discovery of Gene Networks Regulating Cytokine-Induced Dysfunction and Apoptosis in Insulin-Producing INS-1 Cells

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New approaches for in silico identification of cytokine-modified beta cell gene networks

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12 December 2020

Divergent roles of IRE1alpha and PERK in the unfolded protein response

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12 December 2020

Interleukin 1 dose-dependently affects the biosynthesis of (pro)insulin in isolated rat islets of Langerhans

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12 December 2020

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

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12 December 2020

Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression

1 reference

12 December 2020

Endoplasmic reticulum stress and the development of diabetes: a review

1 reference

12 December 2020

Calreticulin, a Ca2+-binding chaperone of the endoplasmic reticulum

1 reference

12 December 2020

10.1007/S00125-007-0609-0

Identifiers

DOI

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18 September 2017

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