(Q40167088)

18 September 2017

1 reference

title

Design and use of potent, specific enzyme inhibitors (English)

1 reference

18 September 2017

1 reference

https://api.crossref.org/works/10.1016/0163-7258(83)90026-8

7 October 2023

author name string

G. R. Stark

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6361807

7 October 2023

P. A. Bartlett

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6361807

7 October 2023

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=6361807

7 October 2023

publication date

1 January 1983

1 reference

full work available at URL

18 September 2017

https://api.elsevier.com/content/article/PII:0163725883900268?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/0163-7258(83)90026-8

https://api.elsevier.com/content/article/PII:0163725883900268?httpAccept=text/plain

7 October 2023

1 reference

https://api.crossref.org/works/10.1016/0163-7258(83)90026-8

Pharmacology & Therapeutics

7 October 2023

published in

1 reference

18 September 2017

volume

23

1 reference

18 September 2017

issue

1

1 reference

18 September 2017

page(s)

45-78

1 reference

Overproduction of the free radical of ribonucleotide reductase in hydroxyurea-resistant mouse fibroblast 3T6 cells

18 September 2017

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Chromosomal Alterations Associated with Overproduction of Asparagine Synthetase in Albizziin-Resistant Chinese Hamster Ovary Cells

7 October 2023

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Selective enhancement of 5-fluorouridine uptake and action in rat hepatomas in vivo following pretreatment with D-galactosamine and 6-azauridine or N-(phosphonacetyl)-L-aspartate

7 October 2023

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A phosphorus-containing pyrimidine analog as a potent inhibitor of cytidine deaminase

7 October 2023

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Bromodeoxyuridine mutagenesis in mammalian cells is related to deoxyribonucleotide pool imbalance

7 October 2023

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Irreversible enzyme inhibitors. 73. Active-site-directed irreversible inhibitors of cytosine nucleoside deaminase derived from 1-phenoxypropyl-5-arylcytosines

7 October 2023

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7 October 2023

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7 October 2023

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7 October 2023

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Allosteric regulation of aspartate transcarbamoylase. Effect of active site ligands on the reactivity of sulfhydryl groups of the regulatory subunits

7 October 2023

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Computer graphics in drug design: molecular modeling of thyroid hormone-prealbumin interactions

7 October 2023

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Cloned cDNA sequences of the hypoxanthine/guanine phosphoribosyltransferase gene from a mouse neuroblastoma cell line found to have amplified genomic sequences

7 October 2023

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7 October 2023

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Unified picture of mechanisms of catalysis by carboxypeptidase A

7 October 2023

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Enhanced 5-Fluorouracil Nucleotide Formation After Methotrexate Administration: Explanation for Drug Synergism

7 October 2023

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Studies of the enzymatic deamination of ara-cytidine. V. inhibition in vitro and in vivo by tetrahydrouridine and other reduced pyrimidine nucleosides

7 October 2023

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Tight-binding inhibitors--III. A new approach for the determination of competition between tight-binding inhibitors and substrates--inhibition of adenosine deaminase by coformycin.

7 October 2023

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A mutant of Chinese hamster ovary cells resistant to alpha-methyl- and alpha-difluoromethylornithine.

7 October 2023

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Photoaffinity Labeling of Biological Systems

7 October 2023

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Inactivation of Bacillus cereus beta-lactamase I by 6 beta-bromopencillanic acid: mechanism

7 October 2023

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Double minutes and homogeneously staining regions: gene amplification in mammalian cells

7 October 2023

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The importance of G0 in the site of action of interferon in the cell cycle

7 October 2023

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Growth regulation of melanoma cells by interferon and (2'-5')oligoadenylate synthetase

7 October 2023

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Selection of tunicamycin-resistant Chinese hamster ovary cells with increased N-acetylglucosaminyltransferase activity

7 October 2023

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Mechanistic studies on the rat kidney flavoenzyme L-α-hydroxy acid oxidase

7 October 2023

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Stepwise isolation and properties of unstable Chinese hamster cell variants that overproduce adenylate deaminase

7 October 2023

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DNA-mediated transfer of multiple drug resistance and plasma membrane glycoprotein expression

7 October 2023

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Response of psoriasis to N-phosphonacetyl-L-aspartate

7 October 2023

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Phase I-phase II trial of N-phosphonacetyl-L-aspartic acid given by intravenous infusion and 5-fluorouracil given by bolus injection

7 October 2023

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Inactivation of the RTEM beta-lactamase from Escherichia coli. Interaction of penam sulfones with enzyme

7 October 2023

61

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Crystal structure of a lysozyme-tetrasaccharide lactone complex

7 October 2023

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Adenosine deaminase and adenylate deaminase: comparative kinetic studies with transition state and ground state analogue inhibitors

7 October 2023

63

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Inhibition of angiotensin-converting enzyme by phosphoramidates and polyphosphates

7 October 2023

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Structure of the flavin adduct formed in the suicide reaction of .alpha.-hydroxybutynoate with D-lactate dehydrogenase

7 October 2023

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Concerted allosteric transition in hybrids of aspartate transcarbamoylase containing different arrangements of active and inactive sites.

7 October 2023

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Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine)

7 October 2023

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Summary of current information on 6-azauridine

7 October 2023

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Comparison of the inhibition of Escherichia coli and Lactobacillus casei dihydrofolate reductase by 2,4-diamino-5-(substituted-benzyl)pyrimidines: quantitative structure-activity relationships, X-ray crystallography, and computer graphics in structu

7 October 2023

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Communication between dissimilar subunits in aspartate transcarbamoylase: Effect of inhibitor and activator on the conformation of the catalytic polypeptide chains

7 October 2023

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Affinity labeling of Escherichia coli ribosomes with a covalently binding derivative of the antibiotic pleuromutilin

7 October 2023

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Binding of hydroxamic acid inhibitors to crystalline thermolysin suggests a pentacoordinate zinc intermediate in catalysis

7 October 2023

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Synthesis and properties of delta-N-(phosphonacetyl)-L-ornithine. A transition-state analog inhibitor of ornithine transcarbamylase

7 October 2023

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Effect of the Transition-State Analogue, delta-N-(Phosphonacetyl)-l-ornithine on Citrulline Synthesis in Isolated Rat-Liver Mitochondria and on Urea Synthesis in Isolated Rat Hepatocytes

7 October 2023

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Purification of ornithine transcarbamylase from rat liver by affinity chromatography with immobilized transition-state analog

7 October 2023

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Allosteric regulation of aspartate transcarbamoylase. Changes in the sedimentation coefficient promoted by the bisubstrate analog N-(phosphonacetyl)-L-aspartate

7 October 2023

86

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What everyone wanted to know about tight binding and enzyme catalysis, but never thought of asking

7 October 2023

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On the attribution and additivity of binding energies

7 October 2023

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Reversal of toxicity and antitumor activity of N-(phosphonacetyl)-L-aspartate by uridine or carbamyl-DL-asparate in vivo

7 October 2023

98

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Effects of N-(phosphonacetyl)-L-aspartate on murine tumors and normal tissues in vivo and in vitro and the relationship of sensitivity to rate of proliferation and level of aspartate transcarbamylase

7 October 2023

100

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Pyrimidine Nucleotide Biosynthesis in Animals: Genes, Enzymes, and Regulation of UMP Biosynthesis

7 October 2023

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Catalytic inhibition of γ-aminobutyric acid-α-ketoglutarate transaminase of bacterial origin by 4-aminohex-5-ynoic acid, a substrate analog

7 October 2023

102

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Mechanism of the stereospecific irreversible inhibition of bacterial glutamic acid decarboxylase by (R)-(-)-4-aminohex-5-ynoic acid, an analog of 4-aminobutyric acid

7 October 2023

103

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Bromodeoxyuridine mutagenesis in mammalian cells: mutagenesis is independent of the amount of bromouracil in DNA

7 October 2023

105

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Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes

7 October 2023

106

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Penicillanic acid sulfone: interaction with RTEM .beta.-lactamase from Escherichia coli at different pH values

7 October 2023

107

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Stable mutants of mammalian cells that overproduce the first three enzymes of pyrimidine nucleotide biosynthesis

7 October 2023

109

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D-PHE-PRO-ARGCH2Cl-A selective affinity label for thrombin

7 October 2023

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Rapid inactivation of cathepsin L by Z-Phe-PheCHN2 and Z-Phe-AlaCHN2

7 October 2023

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Organofluorine synthesis via photofluorination: 3-fluoro-D-alanine and 2-deuterio analogue, antibacterials related to the bacterial cell wall

7 October 2023

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Serine Proteases: Structure and Mechanism of Catalysis

7 October 2023

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Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogues

7 October 2023

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Real-time color graphics in studies of molecular interactions

7 October 2023

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Inhibition of orotidine-5'-phosphate decarboxylase by 1-(5'-phospho-beta-d-ribofuranosyl)barbituric acid, 6-azauridine 5'-phosphate, and uridine 5'-phosphate

7 October 2023

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Thiohemiacetal formation by inhibitory aldehydes at the active site of papain

7 October 2023

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Genetic characterization of hydroxyurea-resistance in chinese hamster ovary cells

7 October 2023

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A novel reaction of the coenzyme of glutamate decarboxylase with L-serine O-sulfate

7 October 2023

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Carboxypeptidase A mechanisms

7 October 2023

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Specificity and reactivity of human granulocyte elastase and cathepsin G, porcine pancreatic elastase, bovine chymotrypsin and trypsin toward inhibition with sulfonyl flourides

7 October 2023

133

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Isolation and initial characterization of the single polypeptide that synthesizes uridine 5'-monophosphate from orotate in Ehrlich ascites carcinoma. Purification by tandem affinity chromatography of uridine-5'-monophosphate synthase

7 October 2023

134

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Initial characterization of a HTC cell variant partially resistant to the anti-proliferative effect of ornithine decarboxylase inhibitors

7 October 2023

135

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7 October 2023

An overview of thymidine

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The structure of the covalent adduct formed by the interaction of 3-dimethylamino-1-propyne and the flavine of mitochondrial amine oxidase

7 October 2023

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Characterization of a mutator gene in Chinese hamster ovary cells

7 October 2023

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The pH dependence of peptide hydrolysis by nitrocarboxypeptidase A

7 October 2023

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Changes in the X-ray solution scattering of aspartate transcarbamylase following the allosteric transition

7 October 2023

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N delta-(phosphonacetyl)-L-ornithine, a potent transition state analogue inhibitor of ornithine carbamoyltransferase

7 October 2023

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Selective inhibition of pyrimidine synthesis and depletion of nucleotide pools by N-(phosphonacetyl)-L-aspartate

7 October 2023

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Pilot study of PALA and 5-FU in patients with advanced cancer

7 October 2023

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Entropy, Binding Energy, and Enzymic Catalysis

7 October 2023

148

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Entropic Contributions to Rate Accelerations in Enzymic and Intramolecular Reactions and the Chelate Effect

7 October 2023

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7 October 2023

Animal Cell Cycle

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Purification and properties of dihydroorotate oxidase from Crithidia fasciculata and Trypanosoma brucei

7 October 2023

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Interaction of ribulosebisphosphate carboxylase/oxygenase with transition-state analogues

7 October 2023

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Inhibition of de novo pyrimidine nucleotide and DNA synthesis and growth of cultured Novikoff rat hepatoma cells and other cell lines by pyrazofurin (NSC 143095)

7 October 2023

156

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Studies on the mechanism of inhibition of glutamine synthetase by methionine sulfoximine

7 October 2023

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Thymidylate Synthetase Overproduction in 5-Fluorodeoxyuridine-Resistant Mouse Fibroblasts

7 October 2023

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Inhibition of glutamine synthetase by methionine sulfoximine. Studies on methionine sulfoximine phosphate

7 October 2023

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Action of decarboxylated S-adenosylmethionine analogs in the spermidine-synthesizing system from rat prostate

7 October 2023

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Perspective on the design and biochemical pharmacology of inhibitors of thymidylate synthetase

7 October 2023

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Gene amplification and drug resistance in cultured murine cells.

7 October 2023

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Inhibition of isocitrate lyase by 3-nitropropionate, a reaction-intermediate analogue

7 October 2023

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Nitro analogues of citrate and isocitrate as transition-state analogues for aconitase

7 October 2023

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Synthesis of 1-chloro-2-oxohexanol 6-phosphate, a covalent active-site reagent for phosphoglucose isomerase

7 October 2023

173

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The structure of the covalent flavin adduct formed between lactate oxidase and the suicide substrate 2-hydroxy-3-butynoate

7 October 2023

174

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The transport and oxidation of succinate by Ehrlich ascites-tumour cells

7 October 2023

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L-lactate transport in Ehrlich ascites-tumour cells

7 October 2023

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Improving the anti-tumor activity of 5-fluorouracil by increasing its incorporation into RNA via metabolic modulation

7 October 2023

183

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Ligand-promoted weakening of intersubunit bonding domains in aspartate transcarbamoylase

7 October 2023

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Bifunctional enzyme activity at the same active site: study of 3 alpha and 20 beta activity by affinity alkylation of 3 alpha, 20 beta-hydroxysteroid dehydrogenase with 17-(bromoacetoxy)steroids

7 October 2023

189

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Nicotinamide adenine dinucleotide binding and promotion of enzyme activity: model based on affinity labeling of 3 alpha, 20 beta-hydroxysteroid dehydrogenase with a nucleoside

7 October 2023

190

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Specific and potent inhibition of spermidine synthase by the transition-state analog, S-adenosyl-3-thio-1,8-diaminooctane

7 October 2023

192

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Synthesis and evaluation of some stable multisubstrate adducts as specific inhibitors of spermidine synthase

7 October 2023

193

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Reaction of peptide aldehydes with serine proteases. Implications for the entropy changes associated with enzymic catalysis

7 October 2023

195

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Phosphorus-containing inhibitors of angiotensin-converting enzyme

7 October 2023

196

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Affinity labeling of human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase with 5'-[p-(fluorosulfonyl)benzoyl]adenosine

7 October 2023

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Antiproliferative agents and differential survival between normal and cancer cells

7 October 2023

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Chemistry of the inactivation of cytosolic aspartate aminotransferase by serine O-sulfate

7 October 2023

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Substrate distortion in catalysis by lysozyme. Interaction of lysozyme with oligosaccharides containing N-acetylxylosamine

7 October 2023

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Single-Copy and Amplified CAD Genes in Syrian Hamster Chromosomes Localized by a Highly Sensitive Method for In Situ Hybridization

7 October 2023

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Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme

7 October 2023

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AMBER: Assisted model building with energy refinement. A general program for modeling molecules and their interactions

7 October 2023

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Identifiers

1 reference

18 September 2017

1 reference