(Q40174504)

English

C-reactive protein induces phosphorylation of insulin receptor substrate-1 on Ser307 and Ser 612 in L6 myocytes, thereby impairing the insulin signalling pathway that promotes glucose transport.

scientific article published on 6 February 2007

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1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17279354%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

C-reactive protein induces phosphorylation of insulin receptor substrate-1 on Ser307 and Ser 612 in L6 myocytes, thereby impairing the insulin signalling pathway that promotes glucose transport (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17279354%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

phosphorylation

1 reference

based on heuristic

inferred from title

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17279354%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17279354%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

author name string

C D'Alessandris

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17279354%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

R Lauro

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17279354%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

publication date

6 February 2007

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17279354%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17279354%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

50

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17279354%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17279354%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

840-849

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17279354%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS).

1 reference

https://api.crossref.org/works/10.1007%2FS00125-006-0522-Y

21 January 2018

C2C12 myocytes lack an insulin-responsive vesicular compartment despite dexamethasone-induced GLUT4 expression.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-006-0522-Y

21 January 2018

Inhibition by forskolin of insulin-stimulated glucose transport in L6 muscle cells

1 reference

https://api.crossref.org/works/10.1007%2FS00125-006-0522-Y

21 January 2018

Tyr(612) and Tyr(632) in human insulin receptor substrate-1 are important for full activation of insulin-stimulated phosphatidylinositol 3-kinase activity and translocation of GLUT4 in adipose cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proapoptotic, antimigratory, antiproliferative, and antiangiogenic effects of commercial C-reactive protein on various human endothelial cell types in vitro: implications of contaminating presence of sodium azide in commercial preparation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The major receptor for C-reactive protein on leukocytes is fcgamma receptor II.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transduction through MAP kinase cascades

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A central role for JNK in obesity and insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-reactive protein-induced in vitro endothelial cell activation is an artefact caused by azide and lipopolysaccharide

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-reactive protein binds to Fc gamma RI in transfected COS cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disruption of IRS-2 causes type 2 diabetes in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-reactive protein stimulates MMP-1 expression in U937 histiocytes through Fc[gamma]RII and extracellular signal-regulated kinase pathway:: an implication of CRP involvement in plaque destabilization

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transduction by the c-Jun N-terminal kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human triglyceride-rich lipoproteins impair glucose metabolism and insulin signalling in L6 skeletal muscle cells independently of non-esterified fatty acid levels.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin receptor substrate-2 phosphorylation is necessary for protein kinase C zeta activation by insulin in L6hIR cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiatherogenic effect of pioglitazone in type 2 diabetic patients irrespective of the responsiveness to its antidiabetic effect

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular smooth muscle cell activation by C-reactive protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced basal activation of mitogen-activated protein kinases in adipocytes from type 2 diabetes: potential role of p38 in the downregulation of GLUT4 expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin resistance and chronic cardiovascular inflammatory syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Body mass index, diabetes, and C-reactive protein among U.S. adults

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defects of the insulin receptor substrate (IRS) system in human metabolic disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-reactive protein activates the nuclear factor-kappaB signal transduction pathway in saphenous vein endothelial cells: implications for atherosclerosis and restenosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-reactive protein-induced in vitro vasorelaxation is an artefact caused by the presence of sodium azide in commercial preparations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of rosiglitazone treatment on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intensive lifestyle intervention or metformin on inflammation and coagulation in participants with impaired glucose tolerance

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subclinical inflammation in newly detected Type II diabetes and impaired glucose tolerance

1 reference

https://pubmed.ncbi.nlm.nih.gov/17279354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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