(Q40176336)

English

The farnesyl transferase inhibitor, tipifarnib, is a potent inhibitor of the MDR1 gene product, P-glycoprotein, and demonstrates significant cytotoxic synergism against human leukemia cell lines

scientific article published on February 2007

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

The farnesyl transferase inhibitor, tipifarnib, is a potent inhibitor of the MDR1 gene product, P-glycoprotein, and demonstrates significant cytotoxic synergism against human leukemia cell lines (English)

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

author name string

B C Medeiros

1

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

H J Landau

2

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

M Morrow

3

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

R O Lockerbie

4

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

T Pitts

5

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

S G Eckhardt

6

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

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publication date

1 February 2007

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

21

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

739-746

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Farnesyltransferase inhibitors: novel compounds in development for the treatment of myeloid malignancies

1 reference

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7 January 2021

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Management of acute myeloid leukemia in elderly patients

1 reference

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Non-Ras targets of farnesyltransferase inhibitors: focus on Rho.

1 reference

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Farnesyl transferase inhibitors: a novel targeted tnerapy for cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404539

7 January 2021

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The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404539

7 January 2021

based on heuristic

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Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

1 reference

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7 January 2021

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Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial

1 reference

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Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development

1 reference

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7 January 2021

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Farnesyl protein transferase inhibitors and other therapies targeting the Ras signal transduction pathway

1 reference

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Saturable P-glycoprotein kinetics assayed by fluorescence studies of drug efflux from suspended human KB8-5 cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404539

7 January 2021

based on heuristic

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Phase I and pharmacokinetic study of the orally administered farnesyl transferase inhibitor R115777 in patients with advanced solid tumors

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Dissection of drug-binding-induced conformational changes in P-glycoprotein.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404539

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure-activity relationship: analyses of p-glycoprotein substrates and inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404539

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction of common azole antifungals with P glycoprotein

1 reference

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based on heuristic

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Effects of the farnesyl transferase inhibitor R115777 on normal and leukemic hematopoiesis

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Farnesyl transferase inhibitors: a major breakthrough in anticancer therapy? Naples, 12 April 2002.

1 reference

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7 January 2021

based on heuristic

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Phosphorylation of p53 on Thr55 by ERK2 is necessary for doxorubicin-induced p53 activation and cell death

1 reference

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7 January 2021

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inferred from DOI database lookup

Identifiers

10.1038/SJ.LEU.2404539

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

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