(Q40204130)

18 September 2017

title

Human let-7a miRNA blocks protein production on actively translating polyribosomes (English)

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18 September 2017

Stephanie Nottrott

1

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18 September 2017

Martin J Simard

series ordinal

2

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18 September 2017

Joel D Richter

series ordinal

3

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18 September 2017

publication date

26 November 2006

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Nature Structural & Molecular Biology

18 September 2017

published in

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18 September 2017

volume

13

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18 September 2017

issue

12

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18 September 2017

page(s)

1108-1114

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MicroRNAs: genomics, biogenesis, mechanism, and function

18 September 2017

cites work

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The functions of animal microRNAs

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microRNA-guided posttranscriptional gene regulation

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Oncomirs - microRNAs with a role in cancer

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The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

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The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor

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The temporal patterning microRNA let-7 regulates several transcription factors at the larval to adult transition in C. elegans

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Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

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RAS is regulated by the let-7 microRNA family

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The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation

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Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation

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Identification of many microRNAs that copurify with polyribosomes in mammalian neurons

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miRNP:mRNA association in polyribosomes in a human neuronal cell line.

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Specificity of microRNA target selection in translational repression

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Short RNAs repress translation after initiation in mammalian cells.

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Inhibition of translational initiation by Let-7 MicroRNA in human cells

31 March 2020

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MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function

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Architecture of a validated microRNA::target interaction.

31 March 2020

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Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation

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MicroRNAs direct rapid deadenylation of mRNA

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mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes

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Dissociation of mammalian polyribosomes into subunits by puromycin

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Micro-RNA regulation of the mammalian lin-28 gene during neuronal differentiation of embryonal carcinoma cells

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Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress

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IRP-1 Binding to Ferritin mRNA Prevents the Recruitment of the Small Ribosomal Subunit by the Cap-Binding Complex eIF4F

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Uncoupling of RNAi from active translation in mammalian cells

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Genome-wide analysis of mRNAs regulated by Drosha and Argonaute proteins in Drosophila melanogaster

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MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies

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Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54

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Human Mpp11 J protein: ribosome-tethered molecular chaperones are ubiquitous

31 March 2020

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A protein complex required for signal-sequence-specific sorting and translocation

31 March 2020

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Synthesis of the posterior determinant Nanos is spatially restricted by a novel cotranslational regulatory mechanism.

31 March 2020

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Localization-dependent oskar protein accumulation; control after the initiation of translation

31 March 2020

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Detecting and measuring cotranslational protein degradation in vivo

31 March 2020

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Sequence-specific inhibition of small RNA function

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Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: comparison of endpoint and real-time methods

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31 March 2020

Identifiers

DOI

10.1038/NSMB1173

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Dimensions Publication ID

18 September 2017

1023746521

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