(Q40207530)

English

Generation and characterization of a stable MK2-EGFP cell line and subsequent development of a high-content imaging assay on the Cellomics ArrayScan platform to screen for p38 mitogen-activated protein kinase inhibitors

scientific article published on January 2006

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scholarly article

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Europe PubMed Central

PubMed publication ID

18 September 2017

Generation and characterization of a stable MK2-EGFP cell line and subsequent development of a high-content imaging assay on the Cellomics ArrayScan platform to screen for p38 mitogen-activated protein kinase inhibitors (English)

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

author name string

Rhonda Gates Williams

1

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Ramani Kandasamy

2

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Debra Nickischer

3

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Oscar J Trask

4

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Carmen Laethem

5

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Patricia A Johnston

6

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Paul A Johnston

7

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Europe PubMed Central

PubMed publication ID

18 September 2017

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publication date

1 January 2006

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Europe PubMed Central

PubMed publication ID

18 September 2017

Methods in Enzymology

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PubMed publication ID

18 September 2017

414

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Europe PubMed Central

PubMed publication ID

18 September 2017

364-389

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Nuclear export inhibitors and kinase inhibitors identified using a MAPK-activated protein kinase 2 redistribution screen

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Mitogen-activated protein kinases: new signaling pathways functioning in cellular responses to environmental stress

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Five-parameter fluorescence imaging: wound healing of living Swiss 3T3 cells

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Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation

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Pharmacological inhibitors of MAPK pathways.

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Protein kinases as targets for anticancer agents: from inhibitors to useful drugs

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Organization and regulation of mitogen-activated protein kinase signaling pathways

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MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis

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Identification of Akt pathway inhibitors using redistribution screening on the FLIPR and the IN Cell 3000 analyzer

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Small-molecule screening and profiling by using automated microscopy

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MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels

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FRET-based detection of different conformations of MK2.

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Protein kinase inhibitors: insights into drug design from structure.

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The p38 signal transduction pathway: activation and function

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Automated screening of neurite outgrowth

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Pyrazole urea-based inhibitors of p38 MAP kinase: from lead compound to clinical candidate

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Using green fluorescent protein to study intracellular signalling.

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Assay development and case history of a 32K-biased library high-content MK2-EGFP translocation screen to identify p38 mitogen-activated protein kinase inhibitors on the ArrayScan 3.1 imaging platform

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

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Characterization of an autoinhibitory domain in human mitogen-activated protein kinase-activated protein kinase 2.

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Identifiers

10.1016/S0076-6879(06)14021-5

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

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