(Q40212744)

18 September 2017

title

BCL2 is a downstream effector of MIZ-1 essential for blocking c-MYC-induced apoptosis (English)

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18 September 2017

Jagruti H Patel

1

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18 September 2017

Steven B McMahon

series ordinal

2

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18 September 2017

language of work or name

English

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publication date

1 November 2006

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Journal of Biological Chemistry

18 September 2017

published in

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18 September 2017

volume

282

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18 September 2017

issue

1

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18 September 2017

page(s)

5-13

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MYC oncogenes and human neoplastic disease

18 September 2017

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Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment

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Transient excess of MYC activity can elicit genomic instability and tumorigenesis

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The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins

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Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis

21 January 2018

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Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis

21 January 2018

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p53 and E2F-1 cooperate to mediate apoptosis

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The Bcl2 family: regulators of the cellular life-or-death switch

21 January 2018

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BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

21 January 2018

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BH3-Only proteins-essential initiators of apoptotic cell death

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Bim is a suppressor of Myc-induced mouse B cell leukemia

21 January 2018

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Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

21 January 2018

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

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A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

21 January 2018

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Molecular characterization of mitochondrial apoptosis-inducing factor

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Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

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Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis

21 January 2018

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c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release

21 January 2018

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Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1.

21 January 2018

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c-Myc Augments Gamma Irradiation-Induced Apoptosis by Suppressing Bcl-XL

21 January 2018

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Induction of cell cycle progression and acceleration of apoptosis are two separable functions of c-Myc: transrepression correlates with acceleration of apoptosis

21 January 2018

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Targeting of Miz-1 is essential for Myc-mediated apoptosis

21 January 2018

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Amplification of IGH/MYC fusion in clinically aggressive IGH/BCL2-positive germinal center B-cell lymphomas.

21 January 2018

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21 January 2018

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An alternative pathway for gene regulation by Myc

21 January 2018

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Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD

21 January 2018

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The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins

21 January 2018

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E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS elimination

21 January 2018

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Myc represses transcription through recruitment of DNA methyltransferase corepressor

21 January 2018

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Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter

21 January 2018

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Negative regulation of the mammalian UV response by Myc through association with Miz-1

21 January 2018

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Promoter-binding and repression of PDGFRB by c-Myc are separable activities

21 January 2018

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Myc antagonizes Ras-mediated growth arrest in leukemia cells through the inhibition of the Ras-ERK-p21Cip1 pathway

21 January 2018

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c-Myc represses the proximal promoters of GADD45a and GADD153 by a post-RNA polymerase II recruitment mechanism

21 January 2018

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Pontin and Reptin regulate cell proliferation in early Xenopus embryos in collaboration with c-Myc and Miz-1.

21 January 2018

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Stimulation of c-MYC transcriptional activity and acetylation by recruitment of the cofactor CBP.

21 January 2018

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Skp2 regulates Myc protein stability and activity

21 January 2018

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Analysis of the Myc and Max interaction specificity with lambda repressor-HLH domain fusions.

21 January 2018

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Max: functional domains and interaction with c-Myc

21 January 2018

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Myc pathways provoking cell suicide and cancer

21 January 2018

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Definition of a consensus binding site for p53

21 January 2018

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WAF1, a potential mediator of p53 tumor suppression

21 January 2018

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Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

21 January 2018

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Akt and 14-3-3eta regulate Miz1 to control cell-cycle arrest after DNA damage

21 January 2018

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Myc-interacting protein 1 target gene profile: a link to microtubules, extracellular signal-regulated kinase, and cell growth

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M609138200

The Myc negative autoregulation mechanism requires Myc-Max association and involves the c-myc P2 minimal promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609138200

Polycomb mediates Myc autorepression and its transcriptional control of many loci in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609138200

Autorepression of c-myc requires both initiator and E2F-binding site elements and cooperation with the p107 gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609138200

Domains of human c-myc protein required for autosuppression and cooperation with ras oncogenes are overlapping

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609138200

Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609138200

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609138200

Identification of chelerythrine as an inhibitor of BclXL function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609138200

Promoting apoptosis as a strategy for cancer drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609138200

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609138200

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609138200

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609138200

Genomic targets of the human c-Myc protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609138200

Analysis of genomic targets reveals complex functions of MYC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609138200

miR-15 and miR-16 induce apoptosis by targeting BCL2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609138200

c-Myc-regulated microRNAs modulate E2F1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609138200

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609138200

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609138200

21 January 2018

Identifiers

DOI

10.1074/JBC.M609138200

1 reference

18 September 2017

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