(Q40217633)

18 September 2017

1 reference

title

Short-term tests for mutagenesis and carcinogenesis in drug toxicology: how to test and when to test is the question (English)

1 reference

18 September 2017

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De La Iglesia FA

1

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18 September 2017

Lake RS

series ordinal

2

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18 September 2017

Fitzgerald JE

series ordinal

3

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18 September 2017

language of work or name

English

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publication date

1 January 1980

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18 September 2017

published in

Drug Metabolism Reviews

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18 September 2017

volume

11

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18 September 2017

issue

1

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18 September 2017

page(s)

103-146

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Evaluation of short-term tests for carcinogenicity

18 September 2017

cites work

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Environmental mutagens and carcinogens

21 January 2018

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Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test

21 January 2018

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Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602538008994023

Development of mutagenicity test using Escherichia coli K-12 as indicator organism.

21 January 2018

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Mutagen testing using TRP+ reversion in Escherichia coli

21 January 2018

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DNA repair synthesis of cultured human cells as a rapid bioassay for chemical carcinogens

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602538008994023

DNA Repair Synthesis in Mammalian Cells exposed to a Series of Oncogenic and Non-Oncogenic Derivatives of 4-Nitroquinoline 1-Oxide

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602538008994023

New Giemsa method for the differential staining of sister chromatids

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Cytological detection of mutagen-carcinogen exposure by sister chromatid exchange

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Chromosome tests with 134 compounds on Chinese hamster cells in vitro--a screening for chemical carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Morphological transformation of early passage golden Syrian hamster embryo cells derived from cryopreserved primary cultures as a reliable in vitro bioassay for identifying diverse carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

I. In vitrol transformation of rat embryo cells: correlations with the known tumorigenic activities of chemicals in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Problems in Interpretation of Experimental Evidence of Cell Transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Carcinogens as Frameshift Mutagens: Metabolites and Derivatives of 2-Acetylaminofluorene and Other Aromatic Amine Carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

An Improved Bacterial Test System for the Detection and Classification of Mutagens and Carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

New developments in mutagenicity screening techniques with yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Procedures used in the induction of mitotic recombination and mutation in the yeast saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Lack of mutagenicity of vinyl chloride in two strains of neurospora crassa

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Mutagenesis of cultured mammalian cells by X-irradiation and ultraviolet light

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Mammalian cell genetics. II. Chemical induction of specific locus mutations in Chinese hamster cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Mutagenicity to mammalian cells of epoxides and other derivatives of polycyclic hydrocarbons

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Genetics of somatic mammalian cells, VII. Induction and isolation of nutritional mutants in Chinese hamster cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Mammalian cell genetics III. Characterization of x-ray-induced forward mutations in chinese hamster cell cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Genetics of somatic mammalian cells XII: Mutagenesis by carcinogenic nitroso compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

The spontaneous azaguanine-resistant mutants of diploid human fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Diploid Azaguanine-Resistant Mutants of Cultured Human Fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Somatic cell mutation detection and quantification of X-ray-induced mutation in cultured, diploid human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Chemical Mutagenesis at the Phosphoribosyltransferase Locus in Cultured Human Lymphoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Detection of chemically induced somatic mutation in Chinese hamsters

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

A mutational assay system for L5178Y mouse lymphoma cells, using hypoxanthine-guanine-phosphoribosyl-transferase (HGPRT) -deficiency as marker. The occurrence of a long expression time for mutations induced by X-rays and EMS

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

A comparison of the 8-azaguanine and ouabain-resistance systems for the selection of induced mutant Chinese hamster cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

A mutational assay system using the thymidine kinase locus in mouse lymphoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Laboratory procedure for assessing specific locus mutations at the TK locus in cultured L5178Y mouse lymphoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Validation and characterization of the L5178Y/TK+/- mouse lymphoma mutagen assay system

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Chemically induced mutation of L-5178Y mouse leukemia cells from asparagine-dependence to asparagine-independence.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Use of the asparagine auxotroph of the L5178Y murine leukemia for the detection of chemical mutagens in vitro and in the host-mediated assay

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Mutagenicity of dimethylnitrosamine and ethyl methanesulfonate as determined by the host-mediated CHO/HGPRT assay

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Microfluorometric detection of deoxyribonucleic acid replication in human metaphase chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Giemsa technique for the detection of sister chromatid exchanges

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Factors involved in differential Giemsa-staining of sister chromatids

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Differential Giemsa staining of sister chromatids and the study of chromatid exchanges without autoradiography.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

The induction of sister-chromatid exchanges in Chinese hamster ovary cells by prolonged exposure to 2-acetylaminofluorene and S-9 mix

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

A modified host-mediated assay using cultured human lymphoid cells in diffusion chambers in mice and cytogenetic effects of cyclophosphamide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Sister chromatid exchange as an assay for genetic damage induced by mutagen-carcinogens. II. In vitro test for compounds requiring metabolic activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Sister chromatid exchanges, indices of human chromosome damage and repair: detection by fluorescence and induction by mitomycin C.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Sister chromatid exchanges induced by mitomycin C: a new method of detecting DNA damage at chromosomal level

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Induction of long-lived chromosome damage, as manifested by sister-chromatid exchange, in lymphocytes of animals exposed to mitomycin-C

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

The use of harlequin staining to assess radiation effects on the in vitro cell cycle kinetics of human lymphcoytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Induction by alkylating agents of sister chromatid exchanges and chromatid breaks in Fanconi's anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

A collaborative study of in vivo cytogenetic analysis. I. Interpretation of slide preparations.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Primary culture of parenchymal liver cells on collagen membranes. Morphological and biochemical observations

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Fractionation of DNA from mammalian cells by alkaline elution

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

A practical procedure for testing DNA damage in vivo, proposed for a pre-screening of chemical carcinogens.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

In vitro measurement of carcinogen-resistant liver cells during hepatocarcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Neoplastic transformation of human diploid fibroblast cells by chemical carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Carcinogenesis in vitro. II. Chemical transformation of diploid human cell cultures: A rare event.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Characterisation of human cells transformed in vitro by urethane

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Heteroploid conversion of human skin cells by methylcholanthrene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Two-stage malignant transformation of rat fibroblasts in tissue culture.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

A method for detecting carcinogenic organic chemicals using mammalian cells in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Relationship between somatic mutation and neoplastic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Relationships between mutation and transformation frequencies in mammalian cells treated “in vitro” with chemical carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Evaluation of six short term tests for detecting organic chemical carcinogens and recommendations for their use.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Gamma-Glutamyl Transpeptidase: A Positive Marker for Cultured Rat Liver Cells Derived From Putative Premalignant and Malignant Lesions2

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Hepatocarcinogenicity of polychlorinated terphenyl (PCT) in ICR mice and its enhancement by hexachlorobenzene (HCB)

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Production of pancreatic acinar cell carcinoma by combined administration of 4-hydroxyaminoquinoline 1-oxide and azaserine in partial pancreatectomized rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

<i>In vitro </i>Culture of Cells Isolated from Dimethylnitrosamine-Induced Renal Mesenchymal Tumors of the Rat

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Early appearance of "transformed" cells from the kidneys of rats treated with a "single" carcinogenic dose of dimethylnitrosamine (DMN) detected by culture in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

In Vitro Culture of Cells Isolated From Dimethylnitrosamine-Induced Renal Mesenchymal Tumors of the Rat. I. Qualitative Morphology 2

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Carcinogenicity of 8-nitroquinoline in Sprague-Dawley rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Does carcinogenic potency correlate with mutagenic potency in the Ames assay?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

The biochemistry of mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

The relationship between carcinogenicity and mutagenicity of some polynuclear hydrocarbons

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

The relationship between mutagenicity and carcinogenicity of some nitrosamines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Mutagenicities of N-nitrosamines on salmonella

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Comparison of the Relative Mutagenic Activity for Eight Antineoplastic Drugs in the Ames Salmonella/Microsome and TK+/− Mouse Lymphoma Assays

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Selection of an in vitro carcinogenicity test for derivatives of the carcinogen hexamethylphosphoramide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Mutagenicity of chemical carcinogens.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Saccharin: An epigenetic carcinogen/mutagen?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

An evaluation of 6 short-term tests for detecting organic chemical carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Comutagenicity, competitive enzyme substrates, and in vitro carcinogenicity assays

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Mutagenicity of commercially available hair dyes‐What Significance for Humans?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

CARCINOGENIC ACTION OF PRONETHALOL.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Lack of carcinogenicity of oxprenolol, a β-adrenergic blocking agent

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Mesovarial leiomyomas in rats in a chronic toxicity study of mesuprine hydrochloride.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Salbutamol: lack of evidence of tumour induction in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Enhancement by Wy-14,643, a hepatic peroxisome proliferator, of diethylnitrosamine-initiated hepatic tumorigenesis in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Appendix I. Structural analysis as a means of predicting carcinogenic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Spontaneous sister chromatid exchanges detected by a BUdR-labelling method

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Sister chromatid exchanges in ageing and repair-deficient human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Sister chromatid exchanges induced by mutagenic carcinogens in normal and xeroderma pigmentosum cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

New principle for the analysis of chemical carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Disruption by Carcinogens of the Hormone Dependent Association of Membranes with Polysomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

Carcinogenicity of ‘Alderlin’ (Pronethalol) in Mice*

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538008994023

10.3109/03602538008994023

21 January 2018

Identifiers

DOI

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1 reference