(Q40225855)

18 September 2017

Untangling ligand induced activation and desensitization of G-protein-coupled receptors (English)

1 reference

G protein-coupled receptor

18 September 2017

0 references

1 reference

Peter J Woolf

1

1 reference

18 September 2017

Jennifer J Linderman

series ordinal

2

1 reference

18 September 2017

language of work or name

English

0 references

publication date

1 January 2003

1 reference

18 September 2017

1 reference

18 September 2017

84

1 reference

18 September 2017

1

1 reference

18 September 2017

3-13

1 reference

Regulators of G-protein signalling as new central nervous system drug targets.

18 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

Drug efficacy at G protein-coupled receptors

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

Beta-blocking agents in heart failure: modern concepts and overview.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

RGS9 proteins facilitate acute tolerance to mu-opioid effects

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

Agonist-induced conformational changes at the cytoplasmic side of transmembrane segment 6 in the beta 2 adrenergic receptor mapped by site-selective fluorescent labeling.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

Increased dopamine D2 receptor binding after long-term treatment with antipsychotics in humans: a clinical PET study

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

Anomalous diffusion of major histocompatibility complex class I molecules on HeLa cells determined by single particle tracking

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

Desensitization of G-protein-coupled receptors in the cardiovascular system

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

Evidence that the nucleotide exchange and hydrolysis cycle of G proteins causes acute desensitization of G-protein gated inward rectifier K+ channels

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

A Monte Carlo study of the dynamics of G-protein activation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

Actions of etorphine hydrochloride, (M99): a potent morphine-like agent

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

Differences in the lateral mobility of receptors for luteinizing hormone (LH) in the luteal cell plasma membrane when occupied by ovine LH versus human chorionic gonadotropin

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

Interaction with Gbetagamma is required for membrane targeting and palmitoylation of Galpha(s) and Galpha(q).

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

Homologous desensitization of the D1A dopamine receptor: efficacy in causing desensitization dissociates from both receptor occupancy and functional potency.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

Influence of receptor density on the patterns of beta2-adrenocepter desensitization

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

G protein-coupled receptors: heterologous regulation of homologous desensitization and its implications.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

Endotoxin induces desensitization of cardiac endothelin-1 receptor signaling by increased expression of RGS4 and RGS16.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

Mu opioid receptor phosphorylation, desensitization, and ligand efficacy

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

Ultra-low doses of naltrexone or etorphine increase morphine's antinociceptive potency and attenuate tolerance/dependence in mice.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

Etorphine binds to multiple opiate receptors of the caudate nucleus with equal affinity but with different kinetics

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

Kinetic evidence for differential agonist and antagonist binding to bovine hippocampal synaptic membrane opioid receptors

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

Agonist-induced desensitization of D1-dopamine receptors linked to adenylyl cyclase activity in cultured NS20Y neuroblastoma cells

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

Homologous desensitization of the D1 dopamine receptor

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

Lateral diffusion of PDGF beta-receptors in human fibroblasts

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

Modeling activation and desensitization of G-protein coupled receptors provides insight into ligand efficacy.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

Mechanistic model of G-protein signal transduction. Determinants of efficacy and effect of precoupled receptors.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

Differential opioid agonist regulation of the mouse mu opioid receptor

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1302589

Internal trafficking and surface mobility of a functionally intact beta2-adrenergic receptor-green fluorescent protein conjugate

20 August 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2803%2974828-0

Localization of the G protein betagamma complex in living cells during chemotaxis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2803%2974828-0

The role of receptor kinases and arrestins in G protein-coupled receptor regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2803%2974828-0

Monte Carlo simulations of membrane signal transduction events: effect of receptor blockers on G-protein activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2803%2974828-0

Regulator of G protein signaling 8 (RGS8) requires its NH2 terminus for subcellular localization and acute desensitization of G protein-gated K+ channels

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2803%2974828-0

Timing is everything the role of kinetics in G protein activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2803%2974828-0

The encounter coupling model for beta-adrenergic receptor/GTP-binding protein interaction in the S49 cell. Calculation of the encounter frequency

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2803%2974828-0

Rapid kinetics of alpha 2-adrenergic inhibition of adenylate cyclase. Evidence for a distal rate-limiting step

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2803%2974828-0

beta-Adrenergic receptor kinase. Activity of partial agonists for stimulation of adenylate cyclase correlates with ability to promote receptor phosphorylation

7 January 2021

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12524261

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Evidence for the role of epinephrine binding frequency in activation of adenylate cyclase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12524261

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/S0006-3495(03)74828-0

1 reference

18 September 2017

1 reference

18 September 2017

PubMed publication ID

12524261

1 reference