(Q40231654)

18 September 2017

Membrane-localized activation of glucuronide prodrugs by beta-glucuronidase enzymes (English)

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18 September 2017

Chen KC

1

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18 September 2017

Cheng TL

2

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18 September 2017

Leu YL

3

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18 September 2017

Prijovich ZM

4

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18 September 2017

Chuang CH

5

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18 September 2017

Chen BM

6

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18 September 2017

Roffler SR

7

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18 September 2017

15 September 2006

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18 September 2017

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18 September 2017

14

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18 September 2017

2

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18 September 2017

187-200

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https://scigraph.springernature.com/pub.10.1038/sj.cgt.7700999

18 September 2017

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cites work

The use of 19F spectroscopy and diffusion-weighted MRI to evaluate differences in gene-dependent enzyme prodrug therapies

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

Intratumoral adenovirus-mediated suicide gene transfer for hepatic metastases from colorectal adenocarcinoma: results of a phase I clinical trial

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

Genetic prodrug activation therapy for breast cancer: A phase I clinical trial of erbB-2-directed suicide gene expression

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

Hypoxia-reoxygenation inhibits gap junctional communication in cultured human umbilical vein endothelial cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

Comparison of the genotoxic and apoptosis-inducing properties of ganciclovir and penciclovir in Chinese hamster ovary cells transfected with the thymidine kinase gene of herpes simplex virus-1: implications for gene therapeutic approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

A phase 1-2 clinical trial of gene therapy for recurrent glioblastoma multiforme by tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir. GLI328 European-Canadian Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

Comparison of two anthracycline-based prodrugs for activation by a monoclonal antibody-beta-glucuronidase conjugate in the specific treatment of cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

A novel doxorubicin-glucuronide prodrug DOX-GA3 for tumour-selective chemotherapy: distribution and efficacy in experimental human ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

Prodrug Mono therapy: synthesis and biological evaluation of an etoposide glucuronide-prodrug

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

Cancer chemotherapy: a SN-38 (7-ethyl-10-hydroxycamptothecin) glucuronide prodrug for treatment by a PMT (Prodrug MonoTherapy) strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

First enzymatically activated Taxotere prodrugs designed for ADEPT and PMT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

Bystander killing of tumour cells by antibody-targeted enzymatic activation of a glucuronide prodrug

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

Secreted human beta-glucuronidase: a novel tool for gene-directed enzyme prodrug therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

Cell surface display of a lysosomal enzyme for extracellular gene-directed enzyme prodrug therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

Anti-tumour activity and toxicity of the new prodrug 9-aminocamptothecin glucuronide (9ACG) in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

Poly(ethylene glycol) modification of beta-glucuronidase-antibody conjugates for solid-tumor therapy by targeted activation of glucuronide prodrugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

Production of cytidine 5'-monophospho-N-acetyl-beta-D-neuraminic acid (CMP-sialic acid) using enzymes or whole cells entrapped in calcium pectate-silica-gel beads

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

Expression of chimeric monomer and dimer proteins on the plasma membrane of mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

Stable expression of chimeric anti-CD3 receptors on mammalian cells for stimulation of antitumor immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

Markers of neoplastic transformation in epithelial cell lines derived from human carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

Design of transgenes for efficient expression of active chimeric proteins on mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

Gene expression imaging by enzymatic catalysis of a fluorescent probe via membrane-anchored beta-glucuronidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

Activation of lymphocytes by anti-CD3 single-chain antibody dimers expressed on the plasma membrane of tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

Structure of human beta-glucuronidase reveals candidate lysosomal targeting and active-site motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

The beta-glucuronidase propeptide contains a serpin-related octamer necessary for complex formation with egasyn esterase and for retention within the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

Human immune response to monoclonal antibody-enzyme conjugates in ADEPT pilot clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

7 January 2021

Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

7 January 2021

Design and synthesis of water-soluble glucuronide derivatives of camptothecin for cancer prodrug monotherapy and antibody-directed enzyme prodrug therapy (ADEPT)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

7 January 2021

Synthesis and biological activity of beta-glucuronyl carbamate-based prodrugs of paclitaxel as potential candidates for ADEPT

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

7 January 2021

Characterization of an antineoplastic glucuronide prodrug

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

7 January 2021

Cure of malignant ascites and generation of protective immunity by monoclonal antibody-targeted activation of a glucuronide prodrug in rats

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

7 January 2021

Efficient clearance of poly(ethylene glycol)-modified immunoenzyme with anti-PEG monoclonal antibody for prodrug cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

7 January 2021

Anti-neoplastic glucuronide prodrug treatment of human tumor cells targeted with a monoclonal antibody-enzyme conjugate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

7 January 2021

Accelerated clearance of polyethylene glycol-modified proteins by anti-polyethylene glycol IgM

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

7 January 2021

Novel strategy for efficient screening and construction of host/vector systems to overproduce penicillin acylase in Escherichia coli

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

7 January 2021

Elevated topoisomerase I activity in cervical cancer as a target for chemoradiation therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

7 January 2021

A methylester of the glucuronide prodrug DOX-GA3 for improvement of tumor-selective chemotherapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700999

7 January 2021

Identifiers

DOI

10.1038/SJ.CGT.7700999

1 reference

Dimensions Publication ID

18 September 2017

0 references

1 reference