(Q40233745)

18 September 2017

title

PEGylation and multimerization of the anti-p185HER-2 single chain Fv fragment 4D5: effects on tumor targeting (English)

1 reference

18 September 2017

5

1 reference

18 September 2017

Susanne Kubetzko

1

1 reference

18 September 2017

Ela Balic

series ordinal

2

1 reference

18 September 2017

Robert Waibel

series ordinal

3

1 reference

18 September 2017

Uwe Zangemeister-Wittke

series ordinal

4

1 reference

18 September 2017

language of work or name

English

0 references

publication date

8 September 2006

1 reference

Journal of Biological Chemistry

18 September 2017

published in

1 reference

18 September 2017

volume

281

1 reference

18 September 2017

issue

46

1 reference

18 September 2017

page(s)

35186-35201

1 reference

Human therapeutic antibodies

18 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Arming antibodies: prospects and challenges for immunoconjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Monoclonal antibodies as therapeutics in oncology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Generating improved single-chain Fv molecules for tumor targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Small molecule nerve growth factor analogs image receptors in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

The pharmacology of monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Antigen specificity and tumour targeting efficiency of a human carcinoembryonic antigen-specific scFv and affinity-matured derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

New protein engineering approaches to multivalent and bispecific antibody fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Permselectivity of the glomerular capillary wall to macromolecules. II. Experimental studies in rats using neutral dextran

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Renal filtration, transport, and metabolism of low-molecular-weight proteins: A review

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Pharmacokinetics and biodistribution of genetically engineered antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Clinical issues in antibody design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Optimizing radiolabeled engineered anti-p185HER2 antibody fragments for in vivo imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

High level Escherichia coli expression and production of a bivalent humanized antibody fragment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Engineering antibodies for imaging and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Tetravalent miniantibodies with high avidity assembling in Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Di-, tri- and tetrameric single chain Fv antibody fragments against human CD19: effect of valency on cell binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Design of multivalent complexes using the barnase*barstar module.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Prolonged in vivo tumour retention of a human diabody targeting the extracellular domain of human HER2/neu

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

High avidity scFv multimers; diabodies and triabodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Biological properties of a human compact anti-ErbB2 antibody.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Design, Construction, and In Vitro Analyses of Multivalent Antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Engineered turns of a recombinant antibody improve its in vivo folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

An intrinsically stable antibody scFv fragment can tolerate the loss of both disulfide bonds and fold correctly

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Rational design of a potent, long-lasting form of interferon: a 40 kDa branched polyethylene glycol-conjugated interferon alpha-2a for the treatment of hepatitis C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Effective drug delivery by PEGylated drug conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Tailoring structure-function and pharmacokinetic properties of single-chain Fv proteins by site-specific PEGylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Biological activities of polyethylene-glycol immunoglobulin conjugates. Resistance to enzymatic degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Crystallization and structure solution of p53 (residues 326-356) by molecular replacement using an NMR model as template

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Protein PEGylation decreases observed target association rates via a dual blocking mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Multicopy suppressors of prc mutant Escherichia coli include two HtrA (DegP) protease homologs (HhoAB), DksA, and a truncated R1pA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Influence of the denticity of ligand systems on the in vitro and in vivo behavior of (99m)Tc(I)-tricarbonyl complexes: a hint for the future functionalization of biomolecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Determination of the immunoreactive function of radiolabeled monoclonal antibodies by linear extrapolation to binding at infinite antigen excess

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Miniantibodies: use of amphipathic helices to produce functional, flexibly linked dimeric FV fragments with high avidity in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

High volumetric yields of functional dimeric miniantibodies in Escherichia coli, using an optimized expression vector and high-cell-density fermentation under non-limited growth conditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Antigen binding forces of individually addressed single-chain Fv antibody molecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Protein disulfide bond formation in prokaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Effect of pegylation on pharmaceuticals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

PEGylated antibodies and antibody fragments for improved therapy: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Antigen binding thermodynamics and antiproliferative effects of chimeric and humanized anti-p185HER2 antibody Fab fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Preparation, characterisation and tumour targeting of cross-linked divalent and trivalent anti-tumour Fab' fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Protein reabsorption in renal proximal tubule-function and dysfunction in kidney pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Radioimmunotherapy of solid tumors by targeting extra domain B fibronectin: identification of the best-suited radioimmunoconjugate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Pharmacokinetic and biodistribution properties of poly(ethylene glycol)–protein conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Characterization of engineered anti-p185HER-2 (scFv-CH3)2 antibody fragments (minibodies) for tumor targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Tumor necrosis factor inhibitors: clinical implications of their different immunogenicity profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Therapeutic antibody fragments with prolonged in vivo half-lives

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

Effects of unpaired cysteines on yield, solubility and activity of different recombinant antibody constructs expressed in E. coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604127200

21 January 2018

Identifiers

DOI

10.1074/JBC.M604127200

1 reference

18 September 2017

1 reference