(Q40246865)

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Underexpressed coactivators PGC1alpha and SRC1 impair hepatocyte nuclear factor 4 alpha function and promote dedifferentiation in human hepatoma cells.

scientific article published on 4 August 2006

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scholarly article

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28 December 2019

Underexpressed coactivators PGC1alpha and SRC1 impair hepatocyte nuclear factor 4 alpha function and promote dedifferentiation in human hepatoma cells (English)

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Europe PubMed Central

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28 December 2019

hepatocellular carcinoma

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based on heuristic

inferred from title

José V Castell

3

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28 December 2019

Celia P Martínez-Jiménez

1

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28 December 2019

4

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28 December 2019

author name string

M José Gómez-Lechón

2

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28 December 2019

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4 August 2006

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28 December 2019

Journal of Biological Chemistry

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28 December 2019

281

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28 December 2019

40

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28 December 2019

29840-29849

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28 December 2019

Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver

1 reference

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21 January 2018

Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells

1 reference

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21 January 2018

Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte nuclear factors

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21 January 2018

Expression and induction of a large set of drug-metabolizing enzymes by the highly differentiated human hepatoma cell line BC2.

1 reference

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21 January 2018

HNF4 and HNF1 as well as a panel of hepatic functions are extinguished and reexpressed in parallel in chromosomally reduced rat hepatoma-human fibroblast hybrids

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21 January 2018

Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily

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21 January 2018

Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis

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21 January 2018

Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: a study using adenovirus-mediated antisense targeting.

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21 January 2018

Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos

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Control of pancreas and liver gene expression by HNF transcription factors

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21 January 2018

Hepatocyte nuclear factor 4 expression overcomes repression of the hepatic phenotype in dedifferentiated hepatoma cells

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21 January 2018

Liver-enriched transcription factors uncoupled from expression of hepatic functions in hepatoma cell lines

1 reference

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21 January 2018

Extinction of alpha1-antitrypsin expression in cell hybrids is independent of HNF1alpha and HNF4 and involves both promoter and internal DNA sequences

1 reference

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21 January 2018

Dissociation of the hepatic phenotype from HNF4 and HNF1alpha expression

1 reference

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21 January 2018

Differentiation of human hepatoma cells during confluence as revealed by gene expression profiling

1 reference

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21 January 2018

Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes

1 reference

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21 January 2018

Genetic analysis of a transcriptional activation pathway by using hepatoma cell variants

1 reference

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21 January 2018

Distinct amino acid residues may be involved in coactivator and ligand interactions in hepatocyte nuclear factor-4alpha

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604046200

21 January 2018

Modulation of transcriptional activation and coactivator interaction by a splicing variation in the F domain of nuclear receptor hepatocyte nuclear factor 4alpha1.

1 reference

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21 January 2018

SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604046200

21 January 2018

CREB-binding protein is a transcriptional coactivator for hepatocyte nuclear factor-4 and enhances apolipoprotein gene expression

1 reference

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21 January 2018

Maturity-onset diabetes of the young Type 1 (MODY1)-associated mutations R154X and E276Q in hepatocyte nuclear factor 4alpha (HNF4alpha) gene impair recruitment of p300, a key transcriptional co-activator

1 reference

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21 January 2018

Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis

1 reference

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21 January 2018

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

1 reference

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21 January 2018

Adenovirus-mediated gene transfer into human hepatocytes: analysis of the biochemical functionality of transduced cells.

1 reference

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21 January 2018

Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis

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21 January 2018

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

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21 January 2018

A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

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21 January 2018

RNAPol-ChIP: a novel application of chromatin immunoprecipitation to the analysis of real-time gene transcription.

1 reference

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21 January 2018

Defective ureagenesis in mice carrying a liver-specific disruption of hepatocyte nuclear factor 4alpha (HNF4alpha ). HNF4alpha regulates ornithine transcarbamylase in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604046200

21 January 2018

The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604046200

21 January 2018

Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis

1 reference

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21 January 2018

Biological control through regulated transcriptional coactivators

1 reference

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21 January 2018

Transcriptional coactivator PGC-1alpha regulates chondrogenesis via association with Sox9

1 reference

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21 January 2018

A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis

1 reference

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21 January 2018

PGC-1, a versatile coactivator

1 reference

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21 January 2018

A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen

1 reference

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21 January 2018

Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression

1 reference

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21 January 2018

Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR.

1 reference

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21 January 2018

CREB regulates hepatic gluconeogenesis through the coactivator PGC-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604046200

21 January 2018

Hepatocyte nuclear factor-4alpha regulates the human apolipoprotein AV gene: identification of a novel response element and involvement in the control by peroxisome proliferator-activated receptor-gamma coactivator-1alpha, AMP-activated protein kina

1 reference

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21 January 2018

The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase I gene expression by cAMP in combination with HNF4 alpha and cAMP-response element-binding protein (CREB)

1 reference

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21 January 2018

Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism.

1 reference

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21 January 2018

Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice

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21 January 2018

Role of accessory factors and steroid receptor coactivator 1 in the regulation of phosphoenolpyruvate carboxykinase gene transcription by glucocorticoids

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21 January 2018

Molecular mechanism for the potentiation of the transcriptional activity of human liver receptor homolog 1 by steroid receptor coactivator-1.

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21 January 2018

Semi-automatic quantitative RT-PCR to measure CYP induction by drugs in human hepatocytes

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Quantitative RT-PCR Measurement of Human Cytochrome P-450s: Application to Drug Induction Studies

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Identifiers

10.1074/JBC.M604046200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16891307%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16891307%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

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