(Q40277377)

19 September 2017

Phase I dose escalation clinical trial of phenylbutyrate sodium administered twice daily to patients with advanced solid tumors (English)

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19 September 2017

phase I clinical trial

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author

Luis H Camacho

1

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19 September 2017

Jon Olson

2

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19 September 2017

William P Tong

3

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19 September 2017

Charles W Young

4

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19 September 2017

David R Spriggs

5

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19 September 2017

Mark G Malkin

6

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19 September 2017

20 October 2006

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Investigational New Drugs

19 September 2017

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19 September 2017

25

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19 September 2017

2

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19 September 2017

131-138

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https://scigraph.springernature.com/pub.10.1007/s10637-006-9017-4

19 September 2017

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cites work

Disposition of phenylbutyrate and its metabolites, phenylacetate and phenylacetylglutamine.

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10637-006-9017-4

Hexamethylene bisacetamide in myelodysplastic syndrome and acute myelogenous leukemia: a phase II clinical trial with a differentiation-inducing agent

21 January 2018

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12 December 2020

Phenylbutyrate induces apoptosis in human prostate cancer and is more potent than phenylacetate

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12 December 2020

Inhibition of proliferation and induction of differentiation in medulloblastoma- and astrocytoma-derived cell lines with phenylacetate

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12 December 2020

The effect of sodium 2-phenylbutyrate in experimental atherosclerosis

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12 December 2020

Enhanced fetal hemoglobin production by phenylacetate and 4-phenylbutyrate in erythroid precursors derived from normal donors and patients with sickle cell anemia and beta-thalassemia

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12 December 2020

Phenylacetate and phenylbutyrate as novel, nontoxic differentiation inducers

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12 December 2020

A Phase I clinical and pharmacological evaluation of sodium phenylbutyrate on an 120-h infusion schedule

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12 December 2020

Effect of butyrate analogues on proliferation and differentiation in human neuroblastoma cell lines

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12 December 2020

Phase I trial and clinical pharmacological evaluation of hexamethylene bisacetamide administration by ten-day continuous intravenous infusion at twenty-eight-day intervals

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12 December 2020

Oral sodium phenylbutyrate in patients with recurrent malignant gliomas: a dose escalation and pharmacologic study

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12 December 2020

Histone deacetylase inhibitors and retinoic acids inhibit growth of human neuroblastoma in vitro.

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12 December 2020

Cytotoxic effects of sodium phenylbutyrate on human neuroblastoma cell lines

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12 December 2020

Interferon in combination with antitumourigenic phenyl derivatives: potentiation of IFN alpha activity in-vitro

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12 December 2020

Plasma protein binding of phenylacetate and phenylbutyrate, two novel antineoplastic agents

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12 December 2020

A phase I and pharmacokinetic study of intravenous phenylacetate in patients with cancer.

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12 December 2020

Pharmacokinetics and cerebrospinal fluid penetration of phenylacetate and phenylbutyrate in the nonhuman primate

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12 December 2020

Pilot study of combination transcriptional modulation therapy with sodium phenylbutyrate and 5-azacytidine in patients with acute myeloid leukemia or myelodysplastic syndrome.

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12 December 2020

Pharmacokinetics of 5-azacitidine administered with phenylbutyrate in patients with refractory solid tumors or hematologic malignancies.

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12 December 2020

Methods for dose finding studies in cancer clinical trials: a review and results of a Monte Carlo study

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12 December 2020

Phenylacetate: a novel nontoxic inducer of tumor cell differentiation

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12 December 2020

Impact of prolonged infusions of the putative differentiating agent sodium phenylbutyrate on myelodysplastic syndromes and acute myeloid leukemia.

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12 December 2020

Treatment of episodic hyperammonemia in children with inborn errors of urea synthesis

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12 December 2020

Vulnerability of multidrug-resistant tumor cells to the aromatic fatty acids phenylacetate and phenylbutyrate

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12 December 2020

Essential amino acid deprivation induces monocytic differentiation of the human HL-60 myeloid leukemia cell line

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12 December 2020

Differentiation of human neuroblastoma by phenylacetate is mediated by peroxisome proliferator-activated receptor gamma

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12 December 2020

Phenylacetylglutamine May Replace Urea as a Vehicle for Waste Nitrogen Excretion

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12 December 2020

Phenylacetate synergizes with retinoic acid in inducing the differentiation of human neuroblastoma cells

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12 December 2020

Phenylbutyrate induces cell differentiation and modulates Epstein-Barr virus gene expression in Burkitt's lymphoma cells

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12 December 2020

Apoptosis after butyrate-induced differentiation in retinoblastoma cell line Y-79.

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12 December 2020

Sodium 4-phenylbutyrate induces apoptosis of human lung carcinoma cells through activating JNK pathway

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12 December 2020

Phenylbutyrate-induced glutamine depletion in humans: effect on leucine metabolism.

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12 December 2020

Induction of erythroid differentiation and fetal hemoglobin production in human leukemic cells treated with phenylacetate

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12 December 2020

Up-regulation and functional role of p21Waf1/Cip1 during growth arrest of human breast carcinoma MCF-7 cells by phenylacetate

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12 December 2020

A phase I dose escalation and bioavailability study of oral sodium phenylbutyrate in patients with refractory solid tumor malignancies.

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12 December 2020

Phase I study of phenylacetate administered twice daily to patients with cancer

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12 December 2020

Growth inhibition, tumor maturation, and extended survival in experimental brain tumors in rats treated with phenylacetate.

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12 December 2020

Inhibition of cell proliferation by potential peroxisome proliferator-activated receptor (PPAR) gamma agonists and antagonists.

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12 December 2020

Phenylbutyrate-induced G1 arrest and apoptosis in myeloid leukemia cells: structure-function analysis

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12 December 2020

Therapeutic targeting of transcription in acute promyelocytic leukemia by use of an inhibitor of histone deacetylase.

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12 December 2020

10.1007/S10637-006-9017-4

Identifiers

DOI

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Dimensions Publication ID

19 September 2017

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