(Q40294227)

English

GW627368X ((N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl} benzene sulphonamide): a novel, potent and selective prostanoid EP4 receptor antagonist

scientific article published on June 2006

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scholarly article

1 reference

Europe PubMed Central

19 September 2017

GW627368X ((N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl} benzene sulphonamide): a novel, potent and selective prostanoid EP4 receptor antagonist (English)

1 reference

Europe PubMed Central

19 September 2017

author name string

Richard J Wilson

1

1 reference

Europe PubMed Central

19 September 2017

Gerard M P Giblin

2

1 reference

Europe PubMed Central

19 September 2017

Susan Roomans

3

1 reference

Europe PubMed Central

19 September 2017

Sharron A Rhodes

4

1 reference

Europe PubMed Central

19 September 2017

Kerri-Ann Cartwright

5

1 reference

Europe PubMed Central

19 September 2017

Vanessa J Shield

6

1 reference

Europe PubMed Central

19 September 2017

Jason Brown

7

1 reference

Europe PubMed Central

19 September 2017

Alan Wise

8

1 reference

Europe PubMed Central

19 September 2017

Jannatara Chowdhury

9

1 reference

Europe PubMed Central

19 September 2017

Sara Pritchard

10

1 reference

Europe PubMed Central

19 September 2017

Jim Coote

11

1 reference

Europe PubMed Central

19 September 2017

Lloyd S Noel

12

1 reference

Europe PubMed Central

19 September 2017

Terry Kenakin

13

1 reference

Europe PubMed Central

19 September 2017

Cynthia L Burns-Kurtis

14

1 reference

Europe PubMed Central

19 September 2017

Valerie Morrison

15

1 reference

Europe PubMed Central

19 September 2017

David W Gray

16

1 reference

Europe PubMed Central

19 September 2017

Heather Giles

17

1 reference

Europe PubMed Central

19 September 2017

language of work or name

0 references

publication date

1 June 2006

1 reference

Europe PubMed Central

19 September 2017

British Journal of Pharmacology

1 reference

Europe PubMed Central

19 September 2017

148

1 reference

Europe PubMed Central

19 September 2017

3

1 reference

Europe PubMed Central

19 September 2017

326-339

1 reference

Europe PubMed Central

19 September 2017

Piglet saphenous vein contains multiple relaxatory prostanoid receptors: evidence for EP4, EP2, DP and IP receptor subtypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

22 September 2017

EP4 prostanoid receptor-mediated vasodilatation of human middle cerebral arteries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

22 September 2017

Some quantitative uses of drug antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

22 September 2017

Translational physiology: porcine models of human coronary artery disease: implications for preclinical trials of therapeutic angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

22 September 2017

Discovery of a potent and selective agonist of the prostaglandin EP4 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

22 September 2017

Semliki forest virus-based expression for versatile use in receptor research

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

22 September 2017

Prostanoid receptor subtypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

22 September 2017

Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

22 September 2017

Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

22 September 2017

The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

22 September 2017

Prostanoid receptors: structures, properties, and functions

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

22 September 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

20 August 2018

Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

22 September 2017

Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

22 September 2017

Cloning and expression of three isoforms of the human EP3 prostanoid receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

22 September 2017

Cloning and expression of the EP3-subtype of human receptors for prostaglandin E2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

22 September 2017

International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

22 September 2017

Allosteric regulation of G-protein-linked receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

22 September 2017

Human prostanoid receptors: cloning and characterization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

22 September 2017

Molecular cloning and characterization of the human prostanoid DP receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

22 September 2017

Analysis of competitive agonist-antagonist interactions by nonlinear regression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

22 September 2017

Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative messenger RNA splicing: multiple second messenger systems and tissue-specific distributions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

22 September 2017

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

22 September 2017

Prostaglandin receptor EP(4) mediates the bone anabolic effects of PGE(2).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

25 September 2017

Endogenous EP4 prostaglandin receptors coupled positively to adenylyl cyclase in Chinese hamster ovary cells: pharmacological characterization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

25 September 2017

The two-state model of agonist action: challenges to pharmacological receptor theory.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

25 September 2017

Characterization of [3H]-prostaglandin E2 binding to prostaglandin EP4 receptors expressed with Semliki Forest virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

15 June 2018

Detection, quantitation, and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: interactions of strychnine and acetylcholine at muscarinic receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

15 June 2018

AH23848: a thromboxane receptor-blocking drug that can clarify the pathophysiologic role of thromboxane A2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

15 June 2018

Discovery of diphenyloxazole and Ndelta-Z-ornithine derivatives as highly potent and selective human prostaglandin EP(4) receptor antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

20 August 2018

Investigation of the agonist activity of prostacyclin analogues on prostanoid EP4 receptors using GW 627368 and taprostene: evidence for species differences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

20 August 2018

A novel, non-prostanoid EP2 receptor-selective prostaglandin E2 agonist stimulates local bone formation and enhances fracture healing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

20 August 2018

Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

20 August 2018

Characterization of chimeric prostacyclin/prostaglandin D(2) receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751567

20 August 2018

EP4-receptors and cyclic AMP in pig venous smooth muscle: evidence with agonists and the EP4-antagonist, AH22921

1 reference

https://pubmed.ncbi.nlm.nih.gov/16604093

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of BW A868C, a prostanoid DP-receptor antagonist, with two receptor subtypes in the rabbit isolated saphenous vein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16604093

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incorporation of Galpha(z)-specific sequence at the carboxyl terminus increases the promiscuity of galpha(16) toward G(i)-coupled receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16604093

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SJ.BJP.0706726

1 reference

Europe PubMed Central

19 September 2017

1 reference

Europe PubMed Central

19 September 2017

1 reference

Europe PubMed Central

19 September 2017

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