(Q40318331)

7 June 2018

title

Integration of a CD19 CAR into the TCR Alpha Chain Locus Streamlines Production of Allogeneic Gene-Edited CAR T Cells (English)

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7 June 2018

author name string

Daniel T MacLeod

1

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7 June 2018

Jeyaraj Antony

2

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7 June 2018

Aaron J Martin

3

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7 June 2018

Rachel J Moser

4

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7 June 2018

Armin Hekele

5

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7 June 2018

Keith J Wetzel

6

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7 June 2018

Audrey E Brown

7

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7 June 2018

Melissa A Triggiano

8

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7 June 2018

Jo Ann Hux

9

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7 June 2018

Christina D Pham

10

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7 June 2018

Victor V Bartsevich

11

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7 June 2018

Caitlin A Turner

12

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7 June 2018

Janel Lape

13

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7 June 2018

Samantha Kirkland

14

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7 June 2018

Clayton W Beard

15

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7 June 2018

Jeff Smith

16

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7 June 2018

Matthew L Hirsch

17

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7 June 2018

Michael G Nicholson

18

1 reference

7 June 2018

Derek Jantz

19

1 reference

7 June 2018

Bruce McCreedy

20

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7 June 2018

publication date

23 February 2017

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7 June 2018

published in

Molecular Therapy

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7 June 2018

volume

25

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7 June 2018

issue

4

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7 June 2018

page(s)

949-961

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7 June 2018

Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells

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1 reference

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Clinical manufacturing of CAR T cells: foundation of a promising therapy

17 June 2018

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AAV Vectorization of DSB-mediated Gene Editing Technologies

17 June 2018

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Translational Implications for Off-the-shelf Immune Cells Expressing Chimeric Antigen Receptors

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patients

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

Highly efficient homology-driven genome editing in human T cells by combining zinc-finger nuclease mRNA and AAV6 donor delivery.

17 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

Evaluation of TCR Gene Editing Achieved by TALENs, CRISPR/Cas9, and megaTAL Nucleases

17 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

Efficient modification of CCR5 in primary human hematopoietic cells using a megaTAL nuclease and AAV donor template

17 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

Generation of knock-in primary human T cells using Cas9 ribonucleoproteins.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

Multiplex Genome-Edited T-cell Manufacturing Platform for "Off-the-Shelf" Adoptive T-cell Immunotherapies

17 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

CD19-Chimeric Antigen Receptor T Cells for Treatment of Chronic Lymphocytic Leukaemia and Acute Lymphoblastic Leukaemia

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

A Multidrug-resistant Engineered CAR T Cell for Allogeneic Combination Immunotherapy

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

Adeno-associated virus at 50: a golden anniversary of discovery, research, and gene therapy success--a personal perspective

17 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

Chimeric antigen receptor T cells for sustained remissions in leukemia

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

mRNA-based therapeutics--developing a new class of drugs

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

Progress and prospects for engineered T cell therapies

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

Gene therapy for Wiskott-Aldrich syndrome--long-term efficacy and genotoxicity

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

Homing endonucleases from mobile group I introns: discovery to genome engineering

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

AAV-mediated gene editing via double-strand break repair

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

Male-sterile maize plants produced by targeted mutagenesis of the cytochrome P450-like gene (MS26) using a re-designed I-CreI homing endonuclease

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

Toward eliminating HLA class I expression to generate universal cells from allogeneic donors

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

The basic principles of chimeric antigen receptor design

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

A strand invasion 3' polymerization intermediate of mammalian homologous recombination

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

Allorecognition and the alloresponse: clinical implications

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

Production and characterization of adeno-associated viral vectors

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

Precise hit: adeno-associated virus in gene targeting

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

Silencing and variegation of gammaretrovirus and lentivirus vectors

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

Human Gene Targeting by Adeno-Associated Virus Vectors Is Enhanced by DNA Double-Strand Breaks

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

Mutations altering the cleavage specificity of a homing endonuclease

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

Putting a price tag on novel autologous cellular therapies.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

Generation of Rag1-knockout immunodeficient rats and mice using engineered meganucleases

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5383629

Rapid and effective CD3 T-cell depletion with a magnetic cell sorting program to produce peripheral blood progenitor cell products for haploidentical transplantation in children and adults

20 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2017.02.005

Depletion of T-cell receptor alpha/beta and CD19 positive cells from apheresis products with the CliniMACS device

7 January 2021

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2017.02.005

10.1016/J.YMTHE.2017.02.005

7 January 2021

Identifiers

DOI

1 reference

7 June 2018

PMC publication ID

5383629

1 reference

7 June 2018

PubMed publication ID

28237835

1 reference

7 June 2018