(Q40326657)

English

Propylthiouracil inhibits the conversion of L-thyroxine to L-triiodothyronine. An explanation of the antithyroxine effect of propylthiouracil and evidence supporting the concept that triiodothyronine is the active thyroid hormone

scientific article published on September 1972

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

Propylthiouracil inhibits the conversion of L-thyroxine to L-triiodothyronine. An explanation of the antithyroxine effect of propylthiouracil and evidence supporting the concept that triiodothyronine is the active thyroid hormone (English)

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

supporting evidence

1 reference

based on heuristic

inferred from title

author name string

Oppenheimer JH

1

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

Schwartz HL

2

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

Surks MI

3

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

language of work or name

0 references

publication date

1 September 1972

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

Journal of Clinical Investigation

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

51

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

9

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

2493-2497

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

Antigoitrogenic and calorigenic activities of thyroxine analogues in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=292418

22 September 2017

The in vivo conversion of thyroxine to 3:5:3'triiodothyronine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=292418

22 September 2017

The extrathyroidal conversion rate of thyroxine to triiodothyronine in normal man

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=292418

22 September 2017

Quantitation of extrathyroidal conversion of l-thyroxine to 3,5,3′-triiodo-l-thyronine in the rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=292418

22 September 2017

Conversion of Thyroxine to Triiodothyronine in Normal Human Subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=292418

22 September 2017

Metabolism of Phenolic- and Tyrosyl-Ring Labeled L-Thyroxine in Human Beings and Rats1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=292418

22 September 2017

Conversion of Thyroxine (T4) to triiodothyronine (T3) in athyreotic human subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=292418

22 September 2017

Role of plasma proteins in the binding, distribution and metabolism of the thyroid hormones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=292418

22 September 2017

Evaluation of the peripheral deiodination of L-thyroxine as an index of its thyrotrophin suppressing effectiveness.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=292418

17 June 2018

Differences in primary cellular factors influencing the metabolism and distribution of 3,5,3'-L-triiodothyronine and L-thyroxine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=292418

17 June 2018

Specific Triiodothyronine Binding Sites in the Anterior Pituitary of the Rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=292418

17 June 2018

Influence of 2-thiouracil and thiamazole on the activity of rat liver L-alpha-glycerophosphate oxidase as a function of L-thyroxine, L-3',3,5-triiodothyronine and L-3'-isopropyl-3,5-diiodothyronine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=292418

17 June 2018

Effect of propylthiouracil and methimazole on the oxygen comsumption of hypothyroid rats receiving thyroxine or triiodothyronine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=292418

17 June 2018

Effects of Propylthiouracil and Thiouracil on the Metabolism of Thyroxine and Several of Its Derivatives by Rat Kidney Slicesin Vitro1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=292418

2 December 2018

Effect of an anti-thyroxine compound on the metabolism of radioactive thyroxine and triiodothyronine in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

THE IDENTIFICATION OF 3:5:3'-L-TRIIODOTHYRONINE IN HUMAN PLASMA

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of triiodo-L-thyronine and L-thyroxine on the oxygen consumption and body weights of rats fed on a diet containing 0.05 percent propylthiouracil

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of thiouracil on rat liver alpha-glycerophosphate dehydrogenase and serum PBI responses to L-thyroxine

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of 3:5:3-L-triiodothyronine and certain anti-thyroxine substances on the oxygen consumption of mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ALPHA-GLYCEROPHOSPHATE DEHYDROGENASE RESPONSE TO THYROXINE IN THYROIDECTOMIZED, THIOURACIL-FED AND TEMPERATURE-ADAPTED RATS

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Propylthiouracil and hepatic clearance of thyroid hormones

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of propylthiouracil, methylthiouracil and thiouracil on the peripheral metabolism of 1-thyroxine in thyroidectomized, 1-thyroxine maintained rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

INFLUENCE OF THYROID HORMONES ON L-ALPHA-GLYCEROPHOSPHATE DEHYDROGENASES AND OTHER DEHYDROGENASES IN VARIOUS ORGANS OF THE RAT

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

I131 excretion after injection of radiothyroxine into hyperthyroid, hypothyroid or normal rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase of the Rate of Release of Thyroidal Iodine-131 and of Circulating Thyrotrophic Activity at Early Stages of Propylthiouracil Treatment in the Rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective inhibition of the calorigenic activities of certain thyroxine analogues with chronic thiouracil treatment in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normal I-131 L-thyroxine metabolism in the presence of potassium perchlorate and interrupted by propylthiouracil

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of propylthiouracil on degradation of I 131-labeled thyroxine and triiodothyronine

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of thiouracil-type drugs on the alpha-glycerophosphate dehydrogenase response to thyroxine analogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic effects of thyroxine injected into normal, thiouracil-treated and thyroidectomized rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dissociation Between Thyroxine Metabolism and Hormonal Action in Phenobarbital-Treated Rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of propylthiouracil on the thyroxine-thyrotropin interplay

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interference with deiodination of some thyroxine analogues in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/4639029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI107063

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

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