Wikidata

(Q4032890)

English

ADAM metallopeptidase domain 17

mammalian protein found in Homo sapiens

  • TNF-alpha-converting enzyme
  • TNF-alpha convertase
  • disintegrin and metalloproteinase domain-containing protein 17
  • ADAM17
  • snake venom-like protease
  • tumor necrosis factor, alpha, converting enzyme
  • TNF-alpha converting enzyme
  • ADAM metallopeptidase domain 18
In more languages

Statements

molecular function
protein binding
determination method
IPI
9 references
retrieved
9 May 2019
stated in
FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex
GOA
curator
UniProt
UniProt protein ID
P78536
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78536
determination method
IPI
retrieved
9 May 2019
stated in
Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78536
determination method
IPI
retrieved
9 May 2019
stated in
Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78536
determination method
IPI
retrieved
9 May 2019
stated in
Identification of SAP97 as an intracellular binding partner of TACE
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78536
determination method
IPI
retrieved
9 May 2019
stated in
Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78536
determination method
IPI
retrieved
9 May 2019
stated in
Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78536
determination method
IPI
retrieved
9 May 2019
stated in
ADAM binding protein Eve-1 is required for ectodomain shedding of epidermal growth factor receptor ligands
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78536
determination method
IPI
retrieved
9 May 2019
stated in
Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78536
determination method
IPI
retrieved
9 May 2019
stated in
Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78536
determination method
IPI
cell component
biological process
membrane protein ectodomain proteolysis
determination method
IDA
IMP
10 references
retrieved
9 May 2019
stated in
ADAM17 (TACE) regulates TGFβ signaling through the cleavage of vasorin
GOA
curator
UniProt
UniProt protein ID
P78536
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78536
determination method
IMP
retrieved
9 May 2019
stated in
TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis
GOA
curator
UniProt
UniProt protein ID
P78536
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78536
determination method
IMP
retrieved
9 May 2019
stated in
Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78536
determination method
IMP
retrieved
9 May 2019
stated in
Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78536
determination method
IMP
retrieved
9 May 2019
stated in
The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78536
determination method
IMP
retrieved
9 May 2019
stated in
TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78536
determination method
IMP
retrieved
9 May 2019
stated in
A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78536
determination method
IDA
retrieved
9 May 2019
stated in
TNF-alpha convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-alpha
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78536
determination method
IDA
retrieved
9 May 2019
stated in
HDLs activate ADAM17-dependent shedding
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78536
determination method
IDA
retrieved
9 May 2019
stated in
Tumor-associated MICA is shed by ADAM proteases
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78536
determination method
IDA
Gene Atlas image
PBB GE ADAM17 205746 s at fs.png
732 × 530; 12 KB
0 references

Identifiers

PDB structure ID
 
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