(Q40333930)

19 September 2017

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title

Clinical pharmacokinetics of hydralazine (English)

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19 September 2017

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T M Ludden

1

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19 September 2017

J L McNay

series ordinal

2

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19 September 2017

A M Shepherd

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3

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19 September 2017

M S Lin

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4

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19 September 2017

1 May 1982

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19 September 2017

21

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Clinical Pharmacokinetics

inferred from page(s)

published in

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19 September 2017

7

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19 September 2017

185-205

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19 September 2017

3

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https://scigraph.springernature.com/pub.10.2165/00003088-198207030-00001

19 September 2017

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cites work

Specific afterload reduction with parenteral hydralazine following cardiac surgery

1 reference

12 December 2020

Determination of hydralazine metabolites: 4-hydrazino-phthalazin-1-one and n-acetylhydrazinophthalazin-1-one by gas chromatography and s-triazolo[3,4-alpha]phthalazine and phthalazinone by high-performance liquid chromatography

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12 December 2020

Pharmacokinetics of hydralazine and its acid-labile hydrazone metabolites in relation to acetylator phenotype

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12 December 2020

Prazosin and hydralazine in congestive heart failure. Regional hemodynamic effects in relation to dose

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12 December 2020

Studies on the direct vasodilator effect of hydralazine in the isolated rabbit renal artery.

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12 December 2020

Pharmacokinetics and cardiovascular effects in rabbits of a major hydralazine metabolite, the hydralazine pyruvic-acid hydrazone

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12 December 2020

Polymorphic acetylation of hydralazine

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12 December 2020

Afterload reduction with hydralazine following valve replacement.

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12 December 2020

Studies on the control of hypertension by hyphex. IV. Levels of the agents in urine and blood

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12 December 2020

Effects of treatment on morbidity in hypertension. Results in patients with diastolic blood pressures averaging 115 through 129 mm Hg

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12 December 2020

High-pressure Liquid Chromatographic Assay for Hydralazine in Human Plasma

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12 December 2020

Identification and quantitation of hydrazine in the urine of patients treated with hydralazine

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12 December 2020

Rheumatic and febrile syndrome during prolonged hydralazine treatment

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12 December 2020

Determination of unchanged hydralazine in plasma by gas-liquid chromatography using nitrogen-specific detection

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12 December 2020

Studies on the control of hypertension by hyphex. II. Toxic reactions and side effects

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12 December 2020

The determination of hydralazine in plasma by gas-liquid chromatography

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12 December 2020

Effects of treatment on morbidity in hypertension. II. Results in patients with diastolic blood pressure averaging 90 through 114 mm Hg

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12 December 2020

Metabolism and disposition of hydralazine-14C in man and dog

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12 December 2020

Variability of plasma hydralazine concentrations in male hypertensive patients

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12 December 2020

Interaction between oral propranolol and hydralazine

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12 December 2020

Relation of hydralazine plasma concentration to dosage and hypotensive action

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12 December 2020

Aromatic amines and hydrazines drug acetylation, and lupus erythematodes

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12 December 2020

Dose requirements of hydralazine in patients with severe chronic congestive heart failure

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12 December 2020

Metabolism of hydralazine in man. Investigation of features relevant to drug safety, Part I

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12 December 2020

Potential effect of early blood sampling schedule on calculated pharmacokinetic parameters of drugs after intravenous administration

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12 December 2020

Kinetic Studies of Hydralazine Reaction with Acetaldehyde

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12 December 2020

Hemodynamic evaluation of hydralazine dosage in refractory heart failure

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12 December 2020

Pharmacokinetics of hydralazine, apparent hydralazine and hydralazine pyruvic acid hydrazone in humans

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12 December 2020

High-performance liquid chromatographic studies of reaction of hydralazine with biogenic aldehydes and ketones

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12 December 2020

Quantitative analysis of hydralazine pyruvic acid hydrazone, the major plasma metabolite of hydralazine

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12 December 2020

Hydralazine and related compounds: chemistry, metabolism, and mode of action

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12 December 2020

Acetylator phenotype and lupus erythematosus

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12 December 2020

Hydralazine kinetics in hypertensive patients after intravenous administration

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12 December 2020

Clinical consequences of polymorphic acetylation of basic drugs

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12 December 2020

Hydrallazine-induced lupus erythematosus-like syndrome in a patient of the rapid acetylator phenotype

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12 December 2020

Late toxicity to hydralazine resembling systemic lupus erythematosus or rheumatoid arthritis

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12 December 2020

The hemodynamic effects of hypotensive drugs in man. IV. 1-Hydrazinophthalazine

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12 December 2020

Hydralazine kinetics after single and repeated oral doses

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12 December 2020

Liquid chromatographic analysis of hydralazine and metabolites in plasma

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12 December 2020

Beneficial effects of hydralazine on rest and exercise hemodynamics in patients with chronic severe aortic insufficiency.

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12 December 2020

Hydralazine urinary metabolites in systemic lupus erythematosus

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12 December 2020

Regional blood flow and cardiac responses to hydralazine.

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12 December 2020

Clinical pharmacokinetics of hydrallazine

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12 December 2020

Disposition of hydralazine in man and a specific method for its determination in biological fluids.

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12 December 2020

Determination of hydralazine pyruvic acid hydrazone and its correlation with "apparent" hydralazine

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12 December 2020

THE METABOLISM OF 1-HYDRAZINOPHTHALAZINE

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12 December 2020

Determination of hydralazine and its acetylated metabolites in urine by gas chromatography and high-pressure liquid chromatography

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12 December 2020

Studies on hydralazine. II. Elimination rate and steady-state concentration in patients with impaired renal function

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12 December 2020

Acetylation of sulfisoxazole by isolated perfused rat kidney

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12 December 2020

Hydralazine tachycardia and sympathetic cardiovascular reactivity in normal subjects

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12 December 2020

Commentary: a physiological approach to hepatic drug clearance

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12 December 2020

Identification of hydrallazine and hydrallazine hydrazone metabolites in human body fluids and quantitative in vitro comparisons of their smooth muscle relaxant activity

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12 December 2020

The comeback of hydralazine

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12 December 2020

Plasma levels of real and "apparent" hydralazine in man and rat

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12 December 2020

Duration of hydralazine action in hypertension

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12 December 2020

Effect of dose on acetylator phenotype distribution of hydralazine

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12 December 2020

A major metabolite of 1-hydrazinophthalazine

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12 December 2020

Genetic effects of hydralazine

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12 December 2020

Drug therapy in renal failure: dosing guidelines for adults. Part II: sedatives, hypnotics, and tranquilizers; cardiovascular, antihypertensive, and diuretic agents; miscellaneous agents

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12 December 2020

Acetylator phenotype and the antihypertensive response to hydralazine

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12 December 2020

Hydralazine: effect on the outflow of noradrenaline and mechanical responses evoked by sympathetic nerve stimulation of the rat tail artery

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12 December 2020

A method of quantitating 1-hydrazinophthalazine in body fluids

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12 December 2020

Endogenous generation of hydralazine from labile hydralazine hydrazones

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12 December 2020

Enhancement of hydralazine bioavailability by food

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12 December 2020

Radioautographic Localization of Hydralazine-1-C14 in Arterial Walls

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12 December 2020

Hydralazine elimination in man

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12 December 2020

A study of the mechanism of the hemodynamic effects of hydralazine in man

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12 December 2020

Food, splanchnic blood flow, and bioavailability of drugs subject to first-pass metabolism

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12 December 2020

A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. II. Alterations in the kinetics of covalent binding.

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12 December 2020

Hydralazine-induced systemic lupus erythematosus: influence of HLA-DR and sex on susceptibility

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12 December 2020

Plasma concentration and acetylator phenotype determine response to oral hydralazine

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12 December 2020

Distribution of hydralazine-1-C-14 after injection into normal mice

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12 December 2020

Interference in Assays for Hydralazine in Humans by a Major Plasma Metabolite, Hydralazine Pyruvic Acid Hydrazone

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12 December 2020

Studies in the rabbit on 3-methyltriazolophthalazine, an acetylated metabolite of hydralazine. Evidence for an alternative route of formation

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12 December 2020

Acetylator phenotype in patients with hydralazine-induced lupoid syndrome.

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12 December 2020

HUMAN ACETYLATION POLYMORPHISM

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12 December 2020

Kinetics of hydralazine and its main metabolites in slow and fast acetylators

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12 December 2020

Relationship of acetyl transferase activity to antinuclear antibodies and toxic symptoms in hypertensive patients treated with hydralazine

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12 December 2020

Metabolism of hydralazine in man

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12 December 2020

Comparative evaluation of the in vitro effects of hydralazine and hydralazine acetonide on arterial smooth muscle

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12 December 2020

Hydralazine-pyrimidine interactions may explain hydralazine-induced lupus erythematosus

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12 December 2020

Eine neue Gruppe blutdrucksenkender Substanzen von besonderem Wirkungscharakter

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12 December 2020

Oral hydralazine therapy for chronic refractory heart failure

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12 December 2020

3-Hydroxymethyl-s-triazolo[3,4-a]phthalazine, a novel urinary hydralazine metabolite in man

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12 December 2020

Metabolism of Hydralazine

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12 December 2020

The effect of oral protein and glucose feeding of splanchnic blood flow and oxygen utilization in normal and cirrhotic subjects

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12 December 2020

Physiological disposition of hydralazine (1-hydrazinophthalazine) and a method for its determination in biological fluids

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12 December 2020

Kinetics of hydralazine elimination

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12 December 2020

Gas chromatographic method for the simultaneous determination of hydralazine and its acetylated metabolite in serum using a nitrogen-selective detector

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12 December 2020

Plasma levels of free and acid-labile hydralazine: effects of multiple dosing and of procainamide

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12 December 2020

Disease and Acetylation Polymorphism

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12 December 2020

Studies on hydralazine. III. Bioavailability of hydralazine in man

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12 December 2020

Dose-dependent changes in sulfamethazine kinetics in rapid and slow isoniazid acetylators

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12 December 2020

Medical intelligence drug therapy

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12 December 2020

Determination of hydralazine and its metabolites by gas chromatography-mass spectrometry

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12 December 2020

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12 December 2020

Screening methods using sulfamethazine for determining acetylator phenotype

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12 December 2020

Selective high-performance liquid chromatographic assays for hydralazine and its metabolites in plasma of man

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12 December 2020

Hydralazine slow-release: observations on serum profile and clinical efficacy in man

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12 December 2020

Identification of the decomposition products of hydralazine hydrazones with three endogenous ketones and kinetic study of the formation of 3-methyl-s-triazolo[3,4,a]phthalazine from hydralazine and pyruvic acid]

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12 December 2020

Noninvasive kinetic approach to the estimation of total hepatic blood flow and shunting in chronic liver disease--a hypothesis

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12 December 2020

10.2165/00003088-198207030-00001

Identifiers

DOI

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Dimensions Publication ID

19 September 2017

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