(Q40341897)

English

Focal expression of interleukin-2 does not break unresponsiveness to "self" (viral) antigen expressed in beta cells but enhances development of autoimmune disease (diabetes) after initiation of an anti-self immune response

scientific article published on February 1995

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

19 September 2017

Focal expression of interleukin-2 does not break unresponsiveness to "self" (viral) antigen expressed in beta cells but enhances development of autoimmune disease (diabetes) after initiation of an anti-self immune response (English)

1 reference

Europe PubMed Central

19 September 2017

autoimmune disease

1 reference

based on heuristic

inferred from title

author name string

M G von Herrath

1

1 reference

Europe PubMed Central

19 September 2017

J Allison

2

1 reference

Europe PubMed Central

19 September 2017

J F Miller

3

1 reference

Europe PubMed Central

19 September 2017

M B Oldstone

4

1 reference

Europe PubMed Central

19 September 2017

language of work or name

0 references

publication date

1 February 1995

1 reference

Europe PubMed Central

19 September 2017

Journal of Clinical Investigation

1 reference

Europe PubMed Central

19 September 2017

95

1 reference

Europe PubMed Central

19 September 2017

477-485

1 reference

Europe PubMed Central

19 September 2017

2

1 reference

Europe PubMed Central

19 September 2017

Activation and differentiation requirements of primary T cells in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

22 September 2017

Lymphocyte responses and cytokines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

22 September 2017

Sensitization to self (virus) antigen by in situ expression of murine interferon-gamma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

22 September 2017

CD28-B7 interactions allow the induction of CD8+ cytotoxic T lymphocytes in the absence of exogenous help.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

22 September 2017

Virus and cytotoxic T lymphocytes: crucial role of viral peptide secondary structure in major histocompatibility complex class I interactions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

22 September 2017

Thymic selection and adaptability of cytotoxic T lymphocyte responses in transgenic mice expressing a viral protein in the thymus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

22 September 2017

Type I diabetes mellitus. A chronic autoimmune disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

22 September 2017

Molecularly engineered vaccine which expresses an immunodominant T-cell epitope induces cytotoxic T lymphocytes that confer protection from lethal virus infection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

22 September 2017

Molecular definition of a major cytotoxic T-lymphocyte epitope in the glycoprotein of lymphocytic choriomeningitis virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

22 September 2017

Molecular pathology of type 1 diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

22 September 2017

Failure of clonal deletion in neonatally thymectomized mice: tolerance is preserved through clonal anergy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

22 September 2017

The IL-2 mediated amplification of cellular cytotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

22 September 2017

Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

22 September 2017

Diversity of T-cell receptors in virus-specific cytotoxic T lymphocytes recognizing three distinct viral epitopes restricted by a single major histocompatibility complex molecule

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

22 September 2017

T cell growth factor: parameters of production and a quantitative microassay for activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

22 September 2017

Differential regulation of murine T lymphocyte subsets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

25 September 2017

Type 2 cytokines and negative immune regulation in human infections

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

25 September 2017

Molecular characterization of the genomic S RNA segment from lymphocytic choriomeningitis virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

17 June 2018

Loss of pancreatic islet tolerance induced by beta-cell expression of interferon-gamma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

17 June 2018

Interleukin 2 abrogates the nonresponsive state of T cells expressing a forbidden T cell receptor repertoire and induces autoimmune disease in neonatally thymectomized mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

17 June 2018

Interleukin 2-dependent activation of tumor-specific cytotoxic T lymphocytes in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

17 June 2018

Effects of cyclosporin A on IL-2 production and lymphocyte proliferation during infection of mice with lymphocytic choriomeningitis virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

17 June 2018

IL-4-supported induction of cytolytic T lymphocytes requires IL-2 and IL-6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

17 June 2018

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

17 June 2018

The role of CD4+ cells in sustaining lymphocyte proliferation during lymphocytic choriomeningitis virus infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

17 June 2018

Heterogeneous mechanisms of human cytotoxic T lymphocyte generation. I. Differential helper cell requirement for the generation of cytotoxic effector cells from CD8+ precursor subpopulations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

17 June 2018

Induction of competence to respond to IL-4 by CD4+ T helper type 1 cells requires costimulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

17 June 2018

Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and tumor necrosis factor-alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

20 August 2018

How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

20 August 2018

Genomic and biological variation among commonly used lymphocytic choriomeningitis virus strains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

20 August 2018

Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

20 August 2018

Autoimmune diabetes as a consequence of locally produced interleukin-2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295493

2 December 2018

Induction of HLA-specific CTL to nonimmunogenic, heat-inactivated lymphocytes by interleukin 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/7860729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 2 counteracts the inhibition of cytotoxic T lymphocytes by cholera toxin in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/7860729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation but not autoimmunity occurs in transgenic mice expressing constitutive levels of interleukin-2 in islet beta cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7860729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of in vitro T cell clonal anergy by IL-2 stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7860729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation and characterization of IL-2-activated veto cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7860729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel LCMV-specific H-2k restricted CTL clones recognize internal viral gene products and cause CNS disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/7860729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-2 reverses human T cell unresponsiveness induced by thymic epithelium in SCID-hu mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/7860729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI117688

1 reference

Europe PubMed Central

19 September 2017

1 reference

Europe PubMed Central

19 September 2017

1 reference

Europe PubMed Central

19 September 2017

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