(Q40346425)

English

SIRT2 inhibition exacerbates neuroinflammation and blood-brain barrier disruption in experimental traumatic brain injury by enhancing NF-κB p65 acetylation and activation

scientific article published on 6 November 2015

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scholarly article

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Europe PubMed Central

PubMed publication ID

19 September 2017

SIRT2 inhibition exacerbates neuroinflammation and blood-brain barrier disruption in experimental traumatic brain injury by enhancing NF-κB p65 acetylation and activation (English)

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

traumatic brain injury

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blood–brain barrier

1 reference

based on heuristic

inferred from title

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26546505%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

author name string

Zhi-Ming Xu

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26546505%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Li-Yan Lu

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26546505%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Hui Nie

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26546505%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Jun Ding

5

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26546505%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Wei-Hai Ying

6

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26546505%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Heng-Li Tian

7

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26546505%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

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publication date

6 November 2015

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Europe PubMed Central

PubMed publication ID

19 September 2017

number of pages

13

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Journal of Neurochemistry

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26546505%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

136

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6 June 2020

3

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6 June 2020

581-593

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26546505%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

NF-kappaB RelA phosphorylation regulates RelA acetylation

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

SIRT2 is required for lipopolysaccharide-induced activation of BV2 microglia

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

ERK1/2 regulates SIRT2 deacetylase activity

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

Mechanisms of cerebral edema in traumatic brain injury: therapeutic developments

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

SIRT1 protects against α-synuclein aggregation by activating molecular chaperones

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

A role for SIRT2-dependent histone H3K18 deacetylation in bacterial infection

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

Responses to the proinflammatory cytokines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and other joint tissues involve nuclear factor kappaB-mediated induction of the Ets transcription factor ESE-1.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

PEP-1-SIRT2 inhibits inflammatory response and oxidative stress-induced cell death via expression of antioxidant enzymes in murine macrophages.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

Curcumin attenuates cerebral edema following traumatic brain injury in mice: a possible role for aquaporin-4?

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

SIRT2 ameliorates lipopolysaccharide-induced inflammation in macrophages.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

Poly(ADP-ribose) polymerase mediates both cell death and ATP decreases in SIRT2 inhibitor AGK2-treated microglial BV2 cells

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

Sirt2 suppresses inflammatory responses in collagen-induced arthritis

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

Traumatic brain injury: a disease process, not an event

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

SIRT2 mediates oxidative stress-induced apoptosis of differentiated PC12 cells

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

SIRT2 as a Therapeutic Target for Age-Related Disorders

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

Sirtuin regulation in calorie restriction.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

Aquaporin-4 expression in cultured astrocytes after fluid percussion injury.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

NF-kappaB-dependent regulation of matrix metalloproteinase-9 gene expression by lipopolysaccharide in a macrophage cell line RAW 264.7.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

SIRT2 regulates NF-κB dependent gene expression through deacetylation of p65 Lys310

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

The microglial "activation" continuum: from innate to adaptive responses

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13423

21 January 2018

Identifiers

10.1111/JNC.13423

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26546505%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26546505%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

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