(Q4035572)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41597

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

image

Protein CCR2 PDB 1KAD.png
640 × 480; 102 KB

0 references

1 reference

13 November 2019

1 reference

13 November 2019

CCR2 chemokine receptor binding

1 reference

8 April 2019

Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

protein homodimerization activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

signal transducer activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41597&geneProductId=UniProtKB:P41597

1 reference

27 March 2018

protein binding

IPI

1 reference

8 April 2019

Structural basis for the interaction of human β-defensin 6 and its putative chemokine receptor CCR2 and breast cancer microvesicles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

IPI

cytokine binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

chemokine (C-C motif) ligand 2 binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

chemokine (C-C motif) ligand 12 binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

chemokine (C-C motif) ligand 7 binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

C-C chemokine receptor activity

3 references

chemokine binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

C-C chemokine binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

integral component of membrane

cell component

Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

8 April 2019

perikaryon

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

1 reference

8 April 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

5 references

8 April 2019

8 April 2019

Human intestinal lamina propria and intraepithelial lymphocytes express receptors specific for chemokines induced by inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

8 April 2019

8 April 2019

Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

8 April 2019

Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

integral component of plasma membrane

1 reference

8 April 2019

Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

neuronal cell body

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

dendrite

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

perinuclear region of cytoplasm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

cytoplasm

1 reference

27 March 2018

Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41597&geneProductId=UniProtKB:P41597

cytosol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

external side of plasma membrane

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41597&geneProductId=UniProtKB:P41597

negative regulation of adenylate cyclase activity

biological process

1 reference

8 April 2019

Organization and differential expression of the human monocyte chemoattractant protein 1 receptor gene. Evidence for the role of the carboxyl-terminal tail in receptor trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

receptor signaling pathway via JAK-STAT

1 reference

8 April 2019

The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

chemokine-mediated signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

cellular calcium ion homeostasis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

positive regulation of monocyte chemotaxis

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

8 April 2019

Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

dendritic cell chemotaxis

1 reference

8 April 2019

The multiple personalities of the chemokine receptor CCR7 in dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

response to wounding

1 reference

8 April 2019

Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

immune response

Chemokine and chemokine-receptor expression in human glial elements: induction by the HIV protein, Tat, and chemokine autoregulation

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41597&geneProductId=UniProtKB:P41597

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41597&geneProductId=UniProtKB:P41597

27 March 2018

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41597&geneProductId=UniProtKB:P41597

inflammatory response

Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41597&geneProductId=UniProtKB:P41597

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41597&geneProductId=UniProtKB:P41597

27 March 2018

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41597&geneProductId=UniProtKB:P41597

viral process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

1 reference

8 April 2019

positive regulation of astrocyte chemotaxis

1 reference

8 April 2019

Functional expression of CCR2 by human fetal astrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

1 reference

8 April 2019

positive regulation of cytosolic calcium ion concentration

1 reference

27 March 2018

Characterization of the CCR2 chemokine receptor: functional CCR2 receptor expression in B cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41597&geneProductId=UniProtKB:P41597

G protein-coupled receptor signaling pathway

monocyte chemotaxis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

humoral immune response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

sensory perception of pain

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41597&geneProductId=UniProtKB:P41597

regulation of cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

homeostasis of number of cells within a tissue

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

leukocyte adhesion to vascular endothelial cell

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

neutrophil clearance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

positive regulation of leukocyte tethering or rolling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

hemopoiesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

chemotaxis

Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

inflammatory response

Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

immune response

Chemokine and chemokine-receptor expression in human glial elements: induction by the HIV protein, Tat, and chemokine autoregulation

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

positive regulation of cytosolic calcium ion concentration

calcium-mediated signaling

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

cell chemotaxis

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

positive regulation of NMDA glutamate receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41597

1 reference

8 April 2019

GPCR, rhodopsin-like, 7TM

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41597

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

0 references

Microsoft Academic ID

0 references

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

2 references

12 October 2015

http://www.uniprot.org/uniprot/P41597.txt?162

14 November 2015

http://www.uniprot.org/uniprot/P41597.txt?version=164

1KP1

2 references

12 October 2015