(Q40373377)

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Assessment of CD8 involvement in T cell clone avidity by direct measurement of HLA-A2/Mage3 complex density using a high-affinity TCR like monoclonal antibody.

scientific article published on October 2005

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6 January 2020

Assessment of CD8 involvement in T cell clone avidity by direct measurement of HLA-A2/Mage3 complex density using a high-affinity TCR like monoclonal antibody (English)

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6 January 2020

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6 January 2020

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Karine Bernardeau

1

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6 January 2020

Sébastien Gouard

2

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6 January 2020

Gaëlle David

3

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6 January 2020

Anne-Lise Ruellan

4

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6 January 2020

Anne Devys

5

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6 January 2020

Marc Bonneville

7

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6 January 2020

Michel Chérel

8

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6 January 2020

François Davodeau

9

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6 January 2020

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1 October 2005

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6 January 2020

European Journal of Immunology

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6 January 2020

35

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6 January 2020

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6 January 2020

2864-2875

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6 January 2020

Manipulation of avidity to improve effectiveness of adoptively transferred CD8(+) T cells for melanoma immunotherapy in human MHC class I-transgenic mice

1 reference

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The density of peptides displayed by dendritic cells affects immune responses to human tyrosinase and gp100 in HLA-A2 transgenic mice

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Antigen density presented by dendritic cells in vivo differentially affects the number and avidity of primary, memory, and recall CD8+ T cells.

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Intravenous injection of a lentiviral vector encoding NY-ESO-1 induces an effective CTL response

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Modification of a tumor-derived peptide at an HLA-A2 anchor residue can alter the conformation of the MHC-peptide complex: probing with TCR-like recombinant antibodies.

1 reference

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21 January 2018

Tax and M1 peptide/HLA-A2-specific Fabs and T cell receptors recognize nonidentical structural features on peptide/HLA-A2 complexes

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21 January 2018

Critical role for CD8 in binding of MHC tetramers to TCR: CD8 antibodies block specific binding of human tumor-specific MHC-peptide tetramers to TCR.

1 reference

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Direct phenotypic analysis of human MHC class I antigen presentation: visualization, quantitation, and in situ detection of human viral epitopes using peptide-specific, MHC-restricted human recombinant antibodies

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Determination of the relationship between T cell responsiveness and the number of MHC-peptide complexes using specific monoclonal antibodies

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21 January 2018

Lipid rafts mediate association of LFA-1 and CD3 and formation of the immunological synapse of CTL.

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21 January 2018

Human tumor antigens for cancer vaccine development

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A listing of human tumor antigens recognized by T cells

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Tetramer-guided analysis of TCR beta-chain usage reveals a large repertoire of melan-A-specific CD8+ T cells in melanoma patients

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Part I: Vaccines for solid tumours

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Rational peptide-based tumour vaccine development and T cell monitoring

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7 January 2021

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Analogues of CTL epitopes with improved MHC class-I binding capacity elicit anti-melanoma CTL recognizing the wild-type epitope

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7 January 2021

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Optimal activation of tumor-reactive T cells by selected antigenic peptide analogues.

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Peptide binding to class I MHC on living cells and quantitation of complexes required for CTL lysis

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Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation

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Competition-based cellular peptide binding assays for 13 prevalent HLA class I alleles using fluorescein-labeled synthetic peptides

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7 January 2021

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Peptide binding to the most frequent HLA-A class I alleles measured by quantitative molecular binding assays

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7 January 2021

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Recombinant antibodies with MHC‐restricted, peptide‐specific, T‐cell receptor‐like specificity: new tools to study antigen presentation and TCR–peptide–MHC interactions

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7 January 2021

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Genetic engineering of T cell specificity for immunotherapy of cancer

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7 January 2021

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A peptide encoded by human gene MAGE-3 and presented by HLA-A2 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE-3.

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Magnetofluorescent liposomes for increased sensitivity of immunofluorescence

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Dissecting cytotoxic T cell responses towards the NY-ESO-1 protein by peptide/MHC-specific antibody fragments

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TCRs with high affinity for foreign pMHC show self-reactivity

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Class I major histocompatibility complex anchor substitutions alter the conformation of T cell receptor contacts

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Modification of peptide interaction with MHC creates TCR partial agonists

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Antimelanoma activity of CTL generated from peripheral blood mononuclear cells after stimulation with autologous dendritic cells pulsed with melanoma gp100 peptide G209-2M is correlated to TCR avidity

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T cell killing does not require the formation of a stable mature immunological synapse.

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An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex

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Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation

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Quantitating protein synthesis, degradation, and endogenous antigen processing

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