(Q40392124)

20 September 2017

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title

Tacrine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in Alzheimer's disease (English)

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20 September 2017

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A J Wagstaff

1

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20 September 2017

D McTavish

series ordinal

2

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20 September 2017

publication date

1 June 1994

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20 September 2017

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20 September 2017

volume

4

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20 September 2017

issue

6

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20 September 2017

page(s)

510-540

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https://scigraph.springernature.com/pub.10.2165/00002512-199404060-00006

20 September 2017

exact match

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cites work

Tetrahydroaminoacridine improves passive avoidance retention defects induced by aging and medial septal lesion but not by fimbria-fornix lesion

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12 December 2020

Direct comparison of cognitive facilitation by physostigmine and tetrahydroaminoacridine in two primate models.

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12 December 2020

Interaction of tacrine and velnacrine with neocortical synaptosomal membranes: relevance to Alzheimer's disease.

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12 December 2020

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

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12 December 2020

THA does not affect sleep or EEG spectral power in Alzheimer's disease

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12 December 2020

Tacrine in Alzheimer's disease

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12 December 2020

Tetrahydroaminoacridine blocks voltage-dependent ion channels in hippocampal neurons

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12 December 2020

Delayed matching-to-sample performance during a double-blind trial of tacrine (THA) and lecithin in patients with Alzheimer's disease.

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12 December 2020

9-Amino-1,2,3,4-tetrahydroacridine (THA) blocks agonist-induced potassium conductance in rat hippocampal neurones

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12 December 2020

Tetrahydroaminoacridine inhibits human and rat brain monoamine oxidase

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12 December 2020

Further analysis of the neuropharmacological profile of 9-amino-1,2,3,4-tetrahydroacridine (THA), an alleged drug for the treatment of Alzheimer's disease

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12 December 2020

Effects of tacrine on insulin secretion and 86Rb+ and 45Ca++ efflux from rat pancreatic islets

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12 December 2020

Physostigmine, tacrine and metrifonate: the effect of multiple doses on acetylcholine metabolism in rat brain.

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12 December 2020

9-Amino-1,2,3,4-tetrahydroacridine is a potent inhibitor of histamine N-methyltransferase

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12 December 2020

Tetrahydroaminoacridine block of N-methyl-D-aspartate-activated cation channels in cultured hippocampal neurons

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12 December 2020

Selective loss of central cholinergic neurons in Alzheimer's disease

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12 December 2020

Tetrahydroaminoacridine improves the spatial acquisition deficit produced by nucleus basalis lesions in rats

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12 December 2020

Quantitative whole-body autoradiographic determination of tacrine tissue distribution in rats following intravenous or oral dose

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12 December 2020

Acute hepatitis after tetrahydroaminoacridine administration for Alzheimer's disease.

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12 December 2020

Pharmacokinetics of tacrine hydrochloride in Alzheimer's disease

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12 December 2020

Neuroreceptor changes in Alzheimer disease

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12 December 2020

Tacrine and lecithin in Alzheimer's disease

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12 December 2020

Tacrine for treating Alzheimer's disease

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12 December 2020

Histamine-induced arousal in the conscious and pentobarbital-pretreated rat.

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12 December 2020

Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease

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12 December 2020

Oral tetrahydroaminoacridine treatment of Alzheimer's disease evaluated clinically and by regional cerebral blood flow and EEG.

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12 December 2020

Evaluation of HP 029 (Velnacrine Maleate) in Alzheimer's Diseasea

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12 December 2020

Interaction of tacrine at M1 and M2 cholinoceptors in guinea pig brain

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12 December 2020

Inhibitory effect of 9-amino-1,2,3,4-tetrahydroacridine (THA) on the potassium current of rabbit sinoatrial node.

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12 December 2020

Tacrine in relation to amino acid transmitters in Alzheimer's disease.

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12 December 2020

Tacrine (tetrahydroaminoacridine; THA) and lecithin in senile dementia of the Alzheimer type: a multicentre trial. Groupe Français d'Etude de la Tetrahydroaminoacridine

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12 December 2020

Muscarinic subtype selectivity of tetrahydroaminoacridine: Possible relationship to its capricious efficacy

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12 December 2020

Functional and pharmacokinetic studies of tetrahydroaminoacridine in patients with amyotrophic lateral sclerosis

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12 December 2020

Characterisation of dopamine and serotonin uptake inhibitory effects of tetrahydroaminoacridine in rat brain

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12 December 2020

Protease inhibitors and indoleamines selectively inhibit cholinesterases in the histopathologic structures of Alzheimer disease

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12 December 2020

A psychopharmacological perspective of cognitive functions. II. Specific pharmacologic agents

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12 December 2020

Pharmacokinetics and effects of 9-amino-1,2,3,4-tetrahydroacridine in the immediate postoperative period in neurosurgical patients

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12 December 2020

The cholinergic system and the excitatory amino acids in Alzheimer's disease

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12 December 2020

The effects of tacrine and zacopride on the performance of adult rats in the working memory task.

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12 December 2020

Anatomy of cholinesterase inhibition in Alzheimer's disease: effect of physostigmine and tetrahydroaminoacridine on plaques and tangles

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12 December 2020

Effects of tetrahydro-9-aminoacridine on cortical and hippocampal neurons in the rat: an in vivo and in vitro study.

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12 December 2020

Tetrahydroaminoacridine induces opposite changes in muscarinic and nicotinic receptors in rat brain.

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12 December 2020

Long-term treatment with tacrine (THA) in Alzheimer's disease--evaluation of neuropsychological data

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12 December 2020

Effects of tetrahydroaminoacridine on liver function in patients with Alzheimer's disease

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12 December 2020

Discrimination of tetrahydroaminoacridine responders by a single dose pharmaco-EEG in patients with Alzheimer's disease.

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12 December 2020

Three-dimensional structure of acetylcholinesterase and of its complexes with anticholinesterase drugs

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12 December 2020

Mechanisms of the tetrahydroaminoacridine effect on action potential and ion currents in myelinated axons.

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12 December 2020

Do tetrahydroaminoacridine (THA) and physostigmine restore acetylcholine release in Alzheimer brains via nicotinic receptors?

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12 December 2020

Chronic treatments with cholinoceptor drugs influence spatial learning in rats.

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12 December 2020

Investigation of the mechanism of the effect of tacrine (tetrahydroaminoacridine) on the metabolism of acetylcholine and choline in brain cortical prisms

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12 December 2020

Clinical experience with and side-effects of tacrine hydrochloride in Alzheimer's disease: a pilot study

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12 December 2020

Tetrahydroaminoacridine inhibits high voltage spindle activity in aged rats after acute and chronic treatment

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12 December 2020

Positive and negative effects of tacrine (tetrahydroaminoacridine) and methoxytacrine on the metabolism of acetylcholine in brain cortical prisms incubated under "resting" conditions

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12 December 2020

Effect of acute arecoline, tacrine, and arecoline + tacrine post-training administration on retention in late middle-aged mice.

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12 December 2020

Reversal by tetrahydroaminoacridine of scopolamine-induced memory and performance deficits in rats

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12 December 2020

Effects of 9-amino-1,2,3,4-tetrahydroacridine (THA), a potential drug for treatment of Alzheimer's disease, on the physical state of human erythrocyte membranes.

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12 December 2020

Utility of an elevated plus-maze for the evaluation of memory in mice: effects of nootropics, scopolamine and electroconvulsive shock

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12 December 2020

Clinical studies in Alzheimer patients with positron emission tomography

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12 December 2020

Tacrine in Alzheimer's disease

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12 December 2020

Influence of tetrahydro-9-aminoacridine on excitatory amino acid release

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12 December 2020

Memory facilitation by histamine

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12 December 2020

Inhibitory effect of 1,2,3,4-tetrahydro-9-aminoacridine on the depolarization-induced release of GABA from cerebral cortex

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12 December 2020

Comparison of the chromatographic characteristics of metabolites of tacrine hydrochloride in human serum and urine with those of in vitro metabolic products from hepatic microsomes

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12 December 2020

SPECT brain imaging in Alzheimer's disease during treatment with oral tetrahydroaminoacridine and lecithin

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12 December 2020

Modest facilitation on memory in dementia with combined lecithin and anticholinerestase treatment.

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12 December 2020

THA and Alzheimer's disease.

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12 December 2020

9-Amino-1,2,3,4-tetrahydroacridine (THA), an alleged drug for the treatment of Alzheimer's disease, inhibits acetylcholinesterase activity and slow outward K+ current

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12 December 2020

The effects of THA on scopolamine and nucleus basalis lesion-induced EEG slowing.

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12 December 2020

Cholinesterases within neurofibrillary tangles related to age and Alzheimer's disease

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12 December 2020

Effects of cholinergic drugs on learning impairment in ventral globus pallidus-lesioned rats.

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12 December 2020

Inhibition of rat brain histamine-N-methyltransferase by 9-amino-1,2,3,4-tetrahydroacridine (THA).

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12 December 2020

Systemic administration of lithium chloride and tacrine increases nitric oxide synthase activity in the hippocampus of rats

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12 December 2020

Open trial of tacrine therapy in 70 HIV-infected patients.

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12 December 2020

9-Amino-1,2,3,4-tetrahydroacridine (THA) is a potent blocker of cardiac potassium channels

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12 December 2020

Distribution of tacrine across the blood-brain barrier in awake, freely moving rats using in vivo microdialysis sampling

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12 December 2020

Blockade of voltage-dependent 42K efflux from rat brain synaptosome by minaprine and tetrahydroaminoacridine

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12 December 2020

Hepatotoxicity of tetrahydroaminoacridine.

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12 December 2020

Effect of tetrahydroaminoacridine on cognition, function and behaviour in Alzheimer's disease.

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12 December 2020

THA increases action potential duration of central histamine neurons in vitro

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12 December 2020

A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease. The Tacrine Collaborative Study Group

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12 December 2020

Clinical pharmacology of tetrahydroaminoacridine: a possible therapeutic agent Alzheimer's disease

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12 December 2020

Oral tetrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer type.

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12 December 2020

Alternatives in the treatment of memory loss in patients with Alzheimer's disease

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12 December 2020

Prevention by choline of the depletion of membrane phosphatidylcholine by a cholinesterase inhibitor

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12 December 2020

Tetrahydroaminoacridine-lecithin combination treatment in patients with intermediate-stage Alzheimer's disease. Results of a Canadian double-blind, crossover, multicenter study.

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12 December 2020

Tetrahydroaminoacridine and physostigmine have opposing effects on probability of transmitter release at the frog neuromuscular junction

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12 December 2020

Tacrine, a drug with therapeutic potential for dementia: post-mortem biochemical evidence

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12 December 2020

Effects of tacrine, aminopyridines, and physostigmine on acetylcholinesterase, acetylcholine release, and potassium currents

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12 December 2020

Studies on new, centrally active and reversible acetylcholinesterase inhibitors.

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12 December 2020

The Prevalence of Dementia in Europe: A Collaborative Study of 1980–1990 Findings

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12 December 2020

Clinical pharmacokinetics of intravenous and oral 9-amino-1,2,3,4-tetrahydroacridine, tacrine

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12 December 2020

Measurements of tacrine and monoamines in brain by in vivo microdialysis argue against release of monoamines by tacrine at therapeutic doses

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12 December 2020

Changes in the regional brain histamine and histidine levels in postmortem brains of Alzheimer patients

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12 December 2020

Metrifonate and tacrine: a comparative study on their effect on acetylcholine dynamics in mouse brain

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12 December 2020

Pharmacological significance of acetylcholinesterase inhibition by tetrahydroaminoacridine

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12 December 2020

Tacrine restores cholinergic nicotinic receptors and glucose metabolism in Alzheimer patients as visualized by positron emission tomography

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12 December 2020

An investigation into the formation of stable, protein-reactive and cytotoxic metabolites from tacrine in vitro. Studies with human and rat liver microsomes

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12 December 2020

Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported.

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12 December 2020

The effect of tacrine (THA) on cycloheximide- and basal forebrain lesion-induced memory deficit in rats

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12 December 2020

An evaluation of the efficacy and safety of tetrahydroaminoacridine (THA) without lecithin in the treatment of Alzheimer's disease.

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12 December 2020

Block of the cardiac pacemaker current (If) in the rabbit sino-atrial node and in canine Purkinje fibres by 9-amino-1,2,3,4-tetrahydroacridine

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12 December 2020

Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies

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12 December 2020

Oral tetrahydroaminoacridine in the treatment of senile dementia, Alzheimer's type

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12 December 2020

Tetrahydroaminoacridine and lecithin in the treatment of Alzheimer's disease. Effect on cognition, functioning in daily life, behavioural disturbances and burden experienced by the carers.

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12 December 2020

Shifting patterns of cortical cholinesterases in Alzheimer's disease: implications for treatment, diagnosis, and pathogenesis.

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12 December 2020

A controlled trial of tacrine in Alzheimer's disease. The Tacrine Study Group

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12 December 2020

Differential effects of physostigmine and 1,2,3,4-tetrahydro-9-aminoacridine on the beta-adrenoceptor transduction system

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12 December 2020

Effect of acute arecoline, tacrine and arecoline + tacrine post-training administration on retention in old mice

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12 December 2020

The effect of tacrine on acetylcholine overflow in the heart

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12 December 2020

Tacrine in Alzheimer's disease

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12 December 2020

Tetrahydroaminoacridine, 3,4 diaminopyridine and physostigmine: direct comparison of effects on memory in aged primates

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12 December 2020

In vitro effects of various cholinesterase inhibitors on acetyl- and butyrylcholinesterase of healthy volunteers.

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12 December 2020

Modulation of gamma-aminobutyric acid release in cerebral cortex by fluoride, phorbol ester, and phosphodiesterase inhibitors: differential sensitivity of acetylcholine release to fluoride and K+ channel blockers.

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12 December 2020

Efficacy of tacrine and lecithin in mild to moderate Alzheimer's disease: double blind trial

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12 December 2020

Tetrahydroaminoacridine facilitates passive avoidance learning in rats with nucleus basalis magnocellularis lesions.

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12 December 2020

Effects of nicotine on local cerebral glucose utilization in the rat.

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12 December 2020

The cholinergic pharmacology of tetrahydroaminoacridine in vivo and in vitro

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12 December 2020

Effects of atipamezole and tetrahydroaminoacridine on nucleus basalis lesion-induced EEG changes.

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12 December 2020

Somatostatin and cognitive functions in Alzheimer's disease--the relationship of cerebrospinal fluid somatostatin increase with clinical response to tetrahydroaminoacridine.

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12 December 2020

Tetrahydroaminoacridine but not 4-aminopyridine inhibits high-affinity choline uptake in striatal and hippocampal synaptosomes

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12 December 2020

Heterogeneity of adverse hepatic reactions to tetrahydroaminoacridine

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12 December 2020

Reduced number of [3H]nicotine and [3H]acetylcholine binding sites in the frontal cortex of Alzheimer brains

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12 December 2020

Effects of THA on ionic currents in myelinated axons of Xenopus laevis

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12 December 2020

Comparison of 4-aminopyridine and tetrahydroaminoacridine on basal forebrain neurons

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12 December 2020

Tetrahydroaminoacridine alleviates medial septal lesion-induced and age-related spatial reference but not working memory deficits.

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12 December 2020

Cholinesterase inhibitor therapy for Alzheimer dementia: what do animal models tell us?

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12 December 2020

Multiple in vitro interactions with and differential in vivo regulation of muscarinic receptor subtypes by tetrahydroaminoacridine

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12 December 2020

Negative Effects of Tacrine (Tetrahydroaminoacridine) and Methoxytacrine on the Metabolism of Acetylcholine in Brain Slices Incubated Under Conditions Stimulating Neurotransmitter Release

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12 December 2020

Tacrine in Alzheimer's disease. Time course of changes in cognitive function and practice effects.

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12 December 2020

Pharmacokinetics of tetrahydroaminoacridine: relations to clinical and biochemical effects in Alzheimer patients

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12 December 2020

Tetrahydroaminoacridine blocks potassium channels and inhibits sodium inactivation in Myxicola.

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12 December 2020

Glucose metabolism and acetylcholine synthesis in relation to neuronal activity in Alzheimer's disease.

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12 December 2020

Serum concentrations of tacrine hydrochloride predict its adverse effects in Alzheimer's disease

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12 December 2020

Evidence for histaminergic arousal mechanisms in the hypothalamus of cat.

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12 December 2020

Tacrine: A pharmacological review

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12 December 2020

The effect of an acute nicotine infusion on the local cerebral glucose utilization of the awake rat

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12 December 2020

Positron emission tomography study of [11C]methyl-tetrahydroaminoacridine (methyl-tacrine) in baboon brain

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12 December 2020

Physostigmine inhibition of 3',5'-cyclic AMP phosphodiesterase from cat sciatic nerve

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12 December 2020

Modulation of EEG rhythmicity and spike activity in the rat hippocampus by systemically administered tetrahydroaminoacridine, scopolamine and atipamezole

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12 December 2020

Effect of long-term treatment with tacrine (THA) in Alzheimer's disease as visualized by PET.

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12 December 2020

Putative mechanisms of action of tacrine in Alzheimer's disease.

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12 December 2020

Interaction of 9-amino-1,2,3,4-tetrahydroaminoacridine (THA) with human cortical nicotinic and muscarinic receptor binding in vitro

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12 December 2020

A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. The Tacrine Study Group.

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12 December 2020

Steady-state pharmacokinetics of tacrine in patients with Alzheimer's disease

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12 December 2020

Interactions between scopolamine and muscarinic cholinergic agonists or cholinesterase inhibitors on spatial alternation performance in rats.

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12 December 2020

The mechanism of tetrahydroaminoacridine-evoked release of endogenous 5-hydroxytryptamine and dopamine from rat brain tissue prisms

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12 December 2020

Tetrahydroaminoacridine selectively attenuates NMDA receptor-mediated neurotoxicity

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12 December 2020

Blockade of a cardiac K+ channel by tacrine: interactions with muscarinic and adenosine receptors

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12 December 2020

Tetrahydroaminoacridine increases acetylcholine synthesis and glucose oxidation by mouse brain slices in vitro

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12 December 2020

Effects of velnacrine, tacrine and physostigmine on tetanic twitch responses at the rat neuromuscular junction

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12 December 2020

Muscarinic Receptor Function and Acetylcholinesterase Activity after Chronic Administration of Tacrine to Mice at Therapeutic Drug Concentrations

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12 December 2020

Correlation of brain levels of 9-amino-1,2,3,4-tetrahydroacridine (THA) with neurochemical and behavioral changes

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12 December 2020

Effect of nicotine and tacrine on acetylcholine release from rat cerebral cortical slices

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12 December 2020

Multiple effects of tetrahydroaminoacridine on the cholinergic system: biochemical and behavioural aspects.

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12 December 2020

Combination of atipamezole and tetrahydroaminoacridine/pilocarpine treatment suppresses high voltage spindle activity in aged rats

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12 December 2020

Low dose tetrahydroaminoacridine (THA) improves cognitive function but does not affect brain acetylcholine in rats.

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12 December 2020

Tacrine slows the rate of ageing of sarin-inhibited acetylcholinesterase

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12 December 2020

Tetrahydroaminoacridine (tacrine) stimulates neurosecretion at mammalian motor endplates

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12 December 2020

Structure-activity investigation of the alteration of the physical state of the skeletal network of proteins in human erythrocyte membranes induced by 9-amino-1,2,3,4-tetrahydroacridine

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12 December 2020

Effects of tacrine, velnacrine (HP029), suronacrine (HP128), and 3,4-diaminopyridine on skeletal neuromuscular transmission in vitro

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12 December 2020

A double-blind, placebo controlled trial of high-dose lecithin in Alzheimer's disease

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12 December 2020

Further analysis of the cognitive effects of tetrahydroaminoacridine (THA) in Alzheimer's disease: assessment of attentional and mnemonic function using CANTAB.

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12 December 2020

Diagnostic and pharmacological approaches in Alzheimer's disease

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12 December 2020

Long-term use of tacrine.

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12 December 2020

Effects of four non-cholinergic cognitive enhancers in comparison with tacrine and galanthamine on scopolamine-induced amnesia in rats

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12 December 2020

Therapeutic trials using tacrine and other cholinesterase inhibitors

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12 December 2020

Comparative effects of alpha-2 receptor agents and THA on the performance of adult and aged rats in the delayed non-matching to position task

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12 December 2020

Comparison of DuP 996, with physostigmine, THA and 3,4-DAP on hypoxia-induced amnesia in rats.

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12 December 2020

Discrimination of Alzheimer patients responding to cholinesterase inhibitor therapy.

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12 December 2020

The relationship of cerebrospinal fluid monoamine metabolites with clinical response to tetrahydroaminoacridine in patients with Alzheimer's disease

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12 December 2020

Learning deficits in aged rats pretreated chronically with barbital and tested late in abstinence: alleviation by tetrahydroaminoacridine.

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12 December 2020

Treatment of Alzheimer's disease with short- and long-term oral THA and lecithin: a double-blind study.

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12 December 2020

Reversibility of the inhibition of acetylcholinesterase by tacrine

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12 December 2020

Psychometric discrimination of tetrahydroaminoacridine responders in Alzheimer patients

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12 December 2020

Do blood pressure and age predict response to tacrine (THA) in Alzheimer's disease? A preliminary report

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12 December 2020

10.2165/00002512-199404060-00006

Identifiers

DOI

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Dimensions Publication ID

20 September 2017

1011504888

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