(Q40397088)

20 September 2017

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title

Paclitaxel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer (English)

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20 September 2017

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C M Spencer

1

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20 September 2017

D Faulds

series ordinal

2

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20 September 2017

language of work or name

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1 November 1994

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20 September 2017

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20 September 2017

48

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20 September 2017

794-847

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20 September 2017

5

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https://scigraph.springernature.com/pub.10.2165/00003495-199448050-00009

20 September 2017

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cites work

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12 December 2020

Cytotoxicity of taxol in vitro against human and rat malignant brain tumors.

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12 December 2020

Taxol stabilizes microtubules in mouse fibroblast cells

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12 December 2020

Cytochrome P450 3A-mediated human liver microsomal taxol 6 alpha-hydroxylation.

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Hypersensitivity reactions from taxol

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Shared actions of endotoxin and taxol on TNF receptors and TNF release

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Ovarian cancer, Part II: Treatment

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Taxol assembles tubulin in the absence of exogenous guanosine 5'-triphosphate or microtubule-associated proteins

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12 December 2020

Taxol-induced neuropathy: further ultrastructural studies of nerve fibre changes in situ

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12 December 2020

Evaluation of taxol cardiotoxicity in metastatic breast cancer

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12 December 2020

Taxol increases steady-state levels of lipopolysaccharide-inducible genes and protein-tyrosine phosphorylation in murine macrophages

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12 December 2020

A phosphoglycoprotein associated with taxol resistance in J774.2 cells.

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12 December 2020

Interstitial taxol delivered from a biodegradable polymer implant against experimental malignant glioma.

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12 December 2020

Comparative in vitro cytotoxicity of taxol and Taxotere against cisplatin-sensitive and -resistant human ovarian carcinoma cell lines

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12 December 2020

Paclitaxel for platinum-refractory ovarian cancer: results from the first 1,000 patients registered to National Cancer Institute Treatment Referral Center 9103.

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12 December 2020

Evaluation of new anticancer agents against the MIA PaCa-2 and PANC-1 human pancreatic carcinoma xenografts

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12 December 2020

Taxol administered as a 120 hour infusion

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12 December 2020

New frontiers in ovarian cancer diagnosis and management

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12 December 2020

Antitumor effect of taxol-containing liposomes in a taxol-resistant murine tumor model

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12 December 2020

Taxol sensitizes human ovarian cancer cells to radiation

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12 December 2020

6 alpha-Hydroxytaxol: isolation and identification of the major metabolite of taxol in human liver microsomes

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12 December 2020

Symptom distress in patients receiving Phase I chemotherapy with taxol

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12 December 2020

Taxol in advanced non-small-cell lung cancer: plus Ca change?

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12 December 2020

Phase II trial of taxol in patients with adenocarcinoma of the upper gastrointestinal tract (UGIT). The Eastern Cooperative Oncology group (ECOG) results

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12 December 2020

Age does not influence taxol dose intensity in recurrent carcinoma of the ovary

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12 December 2020

Cell kill kinetics and cell cycle effects of taxol on human and hamster ovarian cell lines.

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12 December 2020

Direct photoaffinity labeling of tubulin with taxol

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12 December 2020

Phase I trial of taxol given as a 3-hour infusion every 21 days

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12 December 2020

Use of paclitaxel (Taxol) in squamous cell carcinoma of the head and neck

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12 December 2020

Taxol induces internucleosomal DNA fragmentation associated with programmed cell death in human myeloid leukemia cells

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12 December 2020

Morphological studies on the effect of taxol on cultured human prostatic cancer cells

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12 December 2020

Effect of new investigational drug taxol on oncolytic activity and stimulation of human lymphocytes

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12 December 2020

Demonstration of the cell cycle positions of taxol-induced "asters" and "bundles" by sequential measurements of tubulin immunofluorescence, DNA content, and autoradiographic labeling of taxol-sensitive and -resistant cells.

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12 December 2020

Taxol and taxotere--current status and future prospects

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12 December 2020

Phase I clinical and pharmacokinetic study of taxol.

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12 December 2020

Phase I and pharmacodynamic study of taxol in refractory acute leukemias.

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12 December 2020

Taxol and radiation recall dermatitis

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12 December 2020

High-performance liquid chromatographic assay for taxol in human plasma and urine and pharmacokinetics in a phase I trial

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12 December 2020

Glutathione depletion by L-buthionine sulfoximine antagonizes taxol cytotoxicity

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12 December 2020

Taxol-induced neuropathy: chronic effects of local injection

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12 December 2020

Cardiac disturbances during the administration of taxol

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12 December 2020

Saturable pharmacokinetics and paclitaxel pharmacodynamics in children with solid tumors

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12 December 2020

Sequences of taxol and cisplatin: a phase I and pharmacologic study

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12 December 2020

Phase I trial of taxol in patients with advanced cancer

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12 December 2020

Apoptotic Cell Death During Treatment of Leukemias

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12 December 2020

Taxol in combination with doxorubicin or etoposide. Possible antagonism in vitro

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12 December 2020

Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines.

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12 December 2020

Antitumor activity of taxol (NSC-125973) in human ovarian carcinomas growing in the peritoneal cavity of nude mice

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12 December 2020

Taxol-induced flexibility of microtubules and its reversal by MAP-2 and Tau

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12 December 2020

Taxol-induced polymerization of purified tubulin. Mechanism of action

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12 December 2020

Taxol sensitizes human astrocytoma cells to radiation

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12 December 2020

Characterization and Intracellular Distribution of Microtubule-Associated Protein 2 in Differentiating Human Neuroblastoma Cells

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12 December 2020

Taxol: a novel radiation sensitizer

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12 December 2020

Taxol, a microtubule-stabilizing antineoplastic agent, induces expression of tumor necrosis factor alpha and interleukin-1 in macrophages

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12 December 2020

Chemotherapy in ovarian carcinoma: present role and future prospects.

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12 December 2020

In vitro cytotoxic activity of Taxol and Taxotere on primary cultures and established cell lines of human ovarian cancer

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12 December 2020

Phase II study of taxol in patients with untreated advanced non-small-cell lung cancer

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12 December 2020

Taxol: a review of its preclinical in vivo antitumor activity

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12 December 2020

Evaluation of new anticancer agents against human pancreatic carcinomas in nude mice.

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12 December 2020

Effects of taxol on human neutrophils

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12 December 2020

Binding of taxol to human plasma, albumin and alpha 1-acid glycoprotein

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12 December 2020

Dose-intense taxol: high response rate in patients with platinum-resistant recurrent ovarian cancer

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12 December 2020

Taxol-induced soft-tissue injury secondary to extravasation: characterization by histopathology and clinical course

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12 December 2020

A mechanism of cellular resistance to drugs that interfere with microtubule assembly

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12 December 2020

Cross-resistance of drug-resistant murine P388 leukemias to taxol in vivo

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12 December 2020

Phase I trial of taxol given as a 24-hour infusion every 21 days: responses observed in metastatic melanoma.

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12 December 2020

Development of polyploidization in taxol-resistant human leukemia cells in vitro.

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12 December 2020

A phase II trial of taxol in metastatic melanoma

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12 December 2020

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12 December 2020

Measurement of cremophor EL following taxol: plasma levels sufficient to reverse drug exclusion mediated by the multidrug-resistant phenotype

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12 December 2020

Taxol: an antimitotic agent with a new mechanism of action

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12 December 2020

Cytotoxic studies of paclitaxel (Taxol) in human tumour cell lines

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12 December 2020

The long-term cellular response to taxol in peripheral nerve: Schwann cell and endoneurial cell changes

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12 December 2020

Effects of Taxotere and taxol on in vitro colony formation of freshly explanted human tumor cells

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12 December 2020

Phase I and pharmacologic study of paclitaxel and cisplatin with granulocyte colony-stimulating factor: neuromuscular toxicity is dose-limiting

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12 December 2020

Phase II Trial of Taxol in Patients with Metastatic Renal Cell Carcinoma

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12 December 2020

Preclinical activity of taxotere (RP 56976, NSC 628503) against freshly explanted clonogenic human tumour cells: comparison with taxol and conventional antineoplastic agents.

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12 December 2020

Phase I study of taxol and granulocyte colony-stimulating factor in patients with refractory ovarian cancer

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12 December 2020

Nerve Growth Factor Attenuates Neurotoxic Effects of Taxol on Spinal Cord-Ganglion Explants from Fetal Mice

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12 December 2020

In vitro studies of Taxol as a radiation sensitizer in human tumor cells

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12 December 2020

Difference in cytotoxicity of paclitaxel against neoplastic and normal cells

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12 December 2020

Enhancement of tumor radioresponse of a murine mammary carcinoma by paclitaxel

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12 December 2020

Taxol, radiation, and oncogenic transformation.

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12 December 2020

Advanced epithelial ovarian cancer: 1993 consensus statements

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12 December 2020

Overview of paclitaxel (Taxol) in advanced lung cancer

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12 December 2020

Effects of free and liposome-encapsulated taxol on two brain tumors xenografted into nude mice

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12 December 2020

Phase I trial of 3-hour infusion of paclitaxel with or without granulocyte colony-stimulating factor in patients with advanced cancer

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12 December 2020

Pharmacokinetics of paclitaxel and metabolites in a randomized comparative study in platinum-pretreated ovarian cancer patients

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12 December 2020

Activity of taxol in patients with squamous cell carcinoma and adenocarcinoma of the esophagus

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12 December 2020

Optic nerve disturbances: a new form of paclitaxel neurotoxicity

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12 December 2020

The ACTH-(4-9) analog, ORG 2766, prevents taxol-induced neuropathy in rats

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12 December 2020

A phase II study of taxol in patients with malignant melanoma

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12 December 2020

Cytoskeletal agents inhibit motility and adherence of human tumor cells

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12 December 2020

Successful re-treatment with taxol after major hypersensitivity reactions.

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12 December 2020

Incapacitating autonomic neuropathy precipitated by taxol

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12 December 2020

Effects of taxol on the macrophage function. Interactions with some immunological parameters

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12 December 2020

The effects of taxol, a microtubule-stabilizing drug, on steroidogenic cells

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12 December 2020

Taxol metabolism by human liver microsomes: identification of cytochrome P450 isozymes involved in its biotransformation

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12 December 2020

Taxol: Twenty Years Later, the Story Unfolds

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12 December 2020

Changes of fast axonal transport by taxol injected subepineurally into the rat sciatic nerve

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12 December 2020

Clinical toxicities encountered with paclitaxel (Taxol).

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12 December 2020

Phase I trial of paclitaxel in children with refractory solid tumors: a Pediatric Oncology Group Study.

1 reference

12 December 2020

Taxol enhances but does not induce interleukin-1 beta and tumor necrosis factor-alpha production

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12 December 2020

Chemotherapy for advanced epithelial ovarian cancer

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12 December 2020

Taxol in advanced, hormone-refractory carcinoma of the prostate. A phase II trial of the Eastern Cooperative Oncology Group

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12 December 2020

3'-(p-azidobenzamido)taxol photolabels the N-terminal 31 amino acids of beta-tubulin

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12 December 2020

Taxol resistant mutants of Chinese hamster ovary cells: genetic biochemical, and cross-resistance studies.

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12 December 2020

Steady-state plasma concentrations and effects of taxol for a 250 mg/m2 dose in combination with granulocyte-colony stimulating factor in patients with ovarian cancer

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12 December 2020

Nerve growth factor prevents toxic neuropathy in mice

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12 December 2020

Cyclic x-ray responses in mammalian cells in vitro

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12 December 2020

Phase I study of taxol using a 5-day intermittent schedule

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12 December 2020

Assembly of purified GDP-tubulin into microtubules induced by taxol and taxotere: reversibility, ligand stoichiometry, and competition.

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12 December 2020

Phase II study of taxol, merbarone, and piroxantrone in stage IV non-small-cell lung cancer: The Eastern Cooperative Oncology Group Results

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12 December 2020

Investigation of taxol as a potential radiation sensitizer

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12 December 2020

Sequence-dependent cytotoxic effects due to combinations of cisplatin and the antimicrotubule agents taxol and vincristine

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12 December 2020

Phase II Trial of Taxol, an Active Drug in the Treatment of Metastatic Breast Cancer

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12 December 2020

Phase I trial of intraperitoneal taxol: a Gynecoloic Oncology Group study

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12 December 2020

Synergistic interaction between cisplatin and taxol in human ovarian carcinoma cells in vitro

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12 December 2020

Phase II study and long-term follow-up of patients treated with taxol for advanced ovarian adenocarcinoma

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12 December 2020

Therapeutic response to taxol of six human tumors xenografted into nude mice.

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12 December 2020

Paclitaxel in doxorubicin-refractory or mitoxantrone-refractory breast cancer: a phase I/II trial of 96-hour infusion.

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12 December 2020

Paclitaxel inhibits progression of mitotic cells to G1 phase by interference with spindle formation without affecting other microtubule functions during anaphase and telephase

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12 December 2020

Evaluation of paclitaxel (taxol), cisplatin, and the combination paclitaxel-cisplatin in ovarian cancer in vitro with the ATP cell viability assay

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12 December 2020

The influence of Cremophor EL on the cell cycle effects of paclitaxel (Taxol) in human tumor cell lines

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12 December 2020

Characteristics of the combination paclitaxel plus doxorubicin in breast cancer cell lines analyzed with the ATP-cell viability assay

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12 December 2020

Taxol: an important new drug in the management of epithelial ovarian cancer

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12 December 2020

Tolerance to antineoplastic agents in children and adults

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12 December 2020

Cremophor-EL enhances taxol efficacy in a multi-drug resistant C1300 neuroblastoma cell line.

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12 December 2020

Taxol produces a predominantly sensory neuropathy

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12 December 2020

Lipopolysaccharide antagonists block taxol-induced signaling in murine macrophages

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12 December 2020

Promotion of microtubule assembly in vitro by taxol

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12 December 2020

Comparison of paclitaxel and docetaxel (Taxotere) in gynecologic and breast cancer cell lines with the ATP-cell viability assay

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12 December 2020

The taxoids: paclitaxel (Taxol) and docetaxel (Taxotere).

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12 December 2020

Divergent effects of taxol on tumor necrosis factor-alpha-mediated cytolysis of ovarian carcinoma cells

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12 December 2020

Taxol-induced neuropathy: short-term effects of local injection

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12 December 2020

Taxol binds to cellular microtubules

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12 December 2020

Paclitaxel and recombinant human granulocyte colony-stimulating factor as initial chemotherapy for metastatic breast cancer

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12 December 2020

Microtubule changes and cytotoxicity in leukemic cell lines treated with taxol.

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12 December 2020

Combined antimicrotubule activity of estramustine and taxol in human prostatic carcinoma cell lines

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12 December 2020

Phase I study of taxol administered as a short i.v. infusion daily for 5 days.

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12 December 2020

Taxol as a radiation sensitizer: a flow cytometric study.

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12 December 2020

A phase I trial of taxol given by a 6-hour intravenous infusion

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12 December 2020

Microtubules, organelle transport, and steroidogenesis in cultured adrenocortical tumor cells. 2. Reversibility of taxol's inhibition of basal and ACTH-induced steroidogenesis is unaccompanied by reversibility of taxol-induced changes in cell ultras

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12 December 2020

Taxol blocks processes essential for prostate tumor cell (PC-3 ML) invasion and metastases

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12 December 2020

Taxol: initial Israeli experience with a novel anticancer agent.

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12 December 2020

Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms

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12 December 2020

In vitro antiproliferative activity of docetaxel (Taxotere), paclitaxel (Taxol) and cisplatin against human tumour and normal bone marrow cells

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12 December 2020

Microtubules, organelle transport, and steroidogenesis in cultured adrenocortical tumor cells. 1. An ultrastructural analysis of cells in which basal and ACTH-induced steroidogenesis was inhibited by taxol

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12 December 2020

Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations

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12 December 2020

10.2165/00003495-199448050-00009

Identifiers

DOI

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Dimensions Publication ID

20 September 2017

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