(Q40397225)

20 September 2017

1 reference

title

Antioxidant and prooxidant functions of DT-diaphorase in quinone metabolism (English)

1 reference

20 September 2017

Cadenas E

1

1 reference

20 September 2017

language of work or name

English

0 references

publication date

1 January 1995

1 reference

20 September 2017

published in

Biochemical Pharmacology

1 reference

20 September 2017

volume

49

1 reference

20 September 2017

issue

2

1 reference

20 September 2017

page(s)

127-140

1 reference

DT diaphorase. I. Purification from the soluble fraction of rat-liver cytoplasm, and properties

20 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

DT-diaphorase: purification, properties, and function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Redox and addition chemistry of quinoid compounds and its biological implications

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

DT-diaphorase and cancer chemotherapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

DT-diaphorase in activation and detoxification of quinones. Bioreductive activation of mitomycin C.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Potential bioreductive alkylating agents. 1. Benzoquinone derivatives

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

DT-diaphorase as a quinone reductase: a cellular control device against semiquinone and superoxide radical formation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Dicoumarol-sensitive glucuronidation of benzo(a)pyrene metabolites in rat liver microsomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Inhibition of mouse glutathione transferases and glutathione peroxidase II by dicumarol and other ligands

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

A note on the inhibition of DT-diaphorase by dicoumarol

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Inhibition of NAD(P)H:quinone acceptor oxidoreductase by flavones: a structure-activity study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Role of DT diaphorase the cytotoxicity of menadione and 4-nitroquinoline-1-oxide in cultured mammalian fibroblastic cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Purified NAD(P)H-quinone oxidoreductase enhances the mutagenicity of dinitropyrenes in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Rat liver DT-diaphorase as a nitroso-reductase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Induction of dna damage by menadione (2-methyl-1,4-naphthoquinone) in primary cultures of rat hepatocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Mechanisms of toxicity of naphthoquinones to isolated hepatocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Quinoneimines as substrates for quinone reductase (NAD(P)H: (quinone-acceptor)oxidoreductase) and the effect of dicumarol on their cytotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Menadione (2-methyl-1,4-naphthoquinone)-induced Ca2+ release from rat-liver mitochondria is caused by NAD(P)H oxidation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Does lung NAD(P)H:quinone reductase (DT-diaphorase) play an antioxidant enzyme role in protection from hyperoxia?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Quinone toxicity in hepatocytes without oxidative stress.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Role of sulfhydryl groups in benzoquinone-induced Ca2+ release by rat liver mitochondria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Molecular mechanisms of quinone cytotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Redox cycling and sulphydryl arylation; their relative importance in the mechanism of quinone cytotoxicity to isolated hepatocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Metabolism and reactions of quinoid anticancer agents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Induction of cell damage by menadione and benzo(a)-pyrene-3,6-quinone in cultures of adult rat hepatocytes and human fibroblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Formation of benzo[a]pyrene-3,6-quinol mono- and diglucuronides in rat liver microsomes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Mechanistic toxicology: a radical perspective

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

CARCINOGENIC AROMATIC HYDROCARBONS: SPECIAL VULNERABILITY OF RATS.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Transcriptional regulator of oxidative stress-inducible genes: direct activation by oxidation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

NAD(P)H:quinone oxidoreductase1 (DT-diaphorase) expression in normal and tumor tissues

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

DT-diaphorase-catalysed reduction of 1,4-naphthoquinone derivatives and glutathionyl-quinone conjugates. Effect of substituents on autoxidation rates

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

One-electron reduction of 2- and 6-methyl-1,4-naphthoquinone bioreductive alkylating agents.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Effect of superoxide dismutase on the autoxidation of substituted hydro- and semi-naphthoquinones

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

DT-diaphorase-catalyzed two-electron reduction of various p-benzoquinone- and 1,4-naphthoquinone epoxides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

DT-diaphorase-catalyzed two-electron reduction of quinone epoxides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Relationship of the single-electron reduction potential of quinones to their reduction by flavoproteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

The one-electron reduction potential of several substrates can be related to their reduction rates by cytochrome P-450 reductase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Intermediates in the aerobic autoxidation of 6-hydroxydopamine: relative importance under different reaction conditions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Auto-oxidation of dialuric acid, divicine and isouramil. Superoxide dependent and independent mechanisms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

On the mechanism of the Mn3(+)-induced neurotoxicity of dopamine:prevention of quinone-derived oxygen toxicity by DT diaphorase and superoxide dismutase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Reduction of adrenochrome by rat liver and brain DT-diaphorase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Induction of antioxidant enzymes and DT-diaphorase in human blood mononuclear cells by light stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Extracellular glutathione and gamma-glutamyl transpeptidase prevent H2O2-induced injury by 2,3-dimethoxy-1,4-naphthoquinone

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Redox cycling of potential antitumor aziridinyl quinones

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

The reduction of anti-tumour diaziridinyl benzoquinones

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Free radical formation from anthracycline antitumour agents and model systems--I. Model naphthoquinones and anthraquinones

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Reductive metabolism of diaziquone (AZQ) in the S9 fraction of MCF-7 cells. II. Enhancement of the alkylating activity of AZQ by NAD(P)H: quinone-acceptor oxidoreductase (DT-diaphorase)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Free radical formation and DNA strand breakage during metabolism of diaziquone by NAD(P)H quinone-acceptor oxidoreductase (DT-diaphorase) and NADPH cytochrome c reductase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

The reductive metabolism of diaziquone (AZQ) in the S9 fraction of MCF-7 cells: free radical formation and NAD(P)H: quinone-acceptor oxidoreductase (DT-diaphorase) activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Thiol oxidation coupled to DT-diaphorase-catalysed reduction of diaziquone. Reductive and oxidative pathways of diaziquone semiquinone modulated by glutathione and superoxide dismutase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Studies on the reaction mechanism of DT diaphorase. Intermediary plateau and trough regions in the initial velocity vs substrate concentration curves

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Cytochrome c reduction by semiquinone radicals can be indirectly inhibited by superoxide dismutase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Bioreductive activation of quinones: redox properties and thiol reactivity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

One- and two-electron reduction of 2-methyl-1,4-naphthoquinone bioreductive alkylating agents: kinetic studies, free-radical production, thiol oxidation and DNA-strand-break formation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Study of the redox properties of naphthazarin (5,8-dihydroxy-1,4-naphthoquinone) and its glutathionyl conjugate in biological reactions: one- and two-electron enzymatic reduction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Effect of glutathione on the redox transitions of naphthohydroquinone derivatives formed during DT-diaphorase catalysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Mechanisms of toxicity of 2- and 5-hydroxy-1,4-naphthoquinone; absence of a role for redox cycling in the toxicity of 2-hydroxy-1,4-naphthoquinone to isolated hepatocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

In vitro cytotoxicities of 1,4-naphthoquinone and hydroxylated 1,4-naphthoquinones to replicating cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

The cytotoxic effects of 5-OH-1,4-naphthoquinone and 5,8-diOH-1,4-naphthoquinone on doxorubicin-resistant human leukemia cells (HL-60)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

The enzymology of doxorubicin quinone reduction in tumour tissue

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

NAD(P)H (quinone acceptor) oxidoreductase (DT-diaphorase)-mediated two-electron reduction of anthraquinone-based antitumour agents and generation of hydroxyl radicals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Hepatic low-level chemiluminescence during redox cycling of menadione and the menadione-glutathione conjugate: relation to glutathione and NAD(P)H:quinone reductase (DT-diaphorase) activity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

The toxicity of menadione (2-methyl-1,4-naphthoquinone) and two thioether conjugates studied with isolated renal epithelial cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Toxicology of quinone-thioethers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

The effects of 2,3,5-(triglutathion-S-yl)hydroquinone on renal mitochondrial respiratory function in vivo and in vitro: possible role in cytotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Developmental toxicity of bromohydroquinone (BHQ) and BHQ-glutathione conjugates in vivo and in whole embryo culture.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Alterations in hepatocyte cytoskeleton caused by redox cycling and alkylating quinones

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Interconversion of NAD(H) to NADP(H). A cellular response to quinone-induced oxidative stress in isolated hepatocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Oxidative stress in mitochondria: its relationship to cellular Ca2+ homeostasis, cell death, proliferation, and differentiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

The role of Ca2+ in cell killing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Glutathionyl- and hydroxyl radical formation coupled to the redox transitions of 1,4-naphthoquinone bioreductive alkylating agents during glutathione two-electron reductive addition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Semiquinone anion radicals formed by the reaction of quinones with glutathione or amino acids

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Formation of glutathione-conjugated semiquinones by the reaction of quinones with glutathione: an ESR study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Peroxidase activation of 1-naphthol to naphthoxy or naphthoxy-derived radicals and their reaction with glutathione

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Superoxide as an intracellular radical sink

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

A thermodynamic appraisal of the radical sink hypothesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Reactions of glutathione and glutathione radicals with benzoquinones

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Oxidation of polyunsaturated fatty acids and lipids through thiyl and sulfonyl radicals: Reaction kinetics, and influence of oxygen and structure of thiyl radicals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

The sensitivity of human tumour cells to quinone bioreductive drugs: what role for DT-diaphorase?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

DT-diaphorase activity correlates with sensitivity to the indoloquinone EO9 in mouse and human colon carcinomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Unusually marked hypoxic sensitization to indoloquinone EO9 and mitomycin C in a human colon-tumour cell line that lacks DT-diaphorase activity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Bioreductive activation of mitomycin C by DT-diaphorase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Reductive activation of mitomycin C: a delicate balance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Biochemical characterization of a mitomycin C resistant colon cancer cell line variant

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Role of the glutathione-glutathione peroxidase cycle in the cytotoxicity of the anticancer quinones

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Bioactivation of Mitomycin C by Xanthine Dehydrogenase From EMT6 Mouse Mammary Carcinoma Tumors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Two structurally related diaziridinylbenzoquinones preferentially cross-link DNA at different sites upon reduction with DT-diaphorase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Alteration in DNA cross-linking and sequence selectivity of a series of aziridinylbenzoquinones after enzymatic reduction by DT-diaphorase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Possible role of DT-diaphorase in the bioactivation of antitumor quinones

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

A comparison of free radical formation by quinone antitumour agents in MCF-7 cells and the role of NAD(P)H (quinone-acceptor) oxidoreductase (DT-diaphorase)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

The Role of NAD(P)H: Quinone Reductase (EC 1.6.99.2, DT-Diaphorase) in the Reductive Bioactivation of the Novel Indoloquinone Antitumor Agent E09

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

Molecular biology of the carcinogen, 4-nitroquinoline 1-oxide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

inferred from DOI database lookup

7 January 2021

based on heuristic

Molecular mechanisms of trenimon-induced cytotoxicity in resistant L5178Y/HBM10 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

inferred from DOI database lookup

7 January 2021

based on heuristic

The role of human and rodent DT-diaphorase in the reductive metabolism of hypoxic cell cytotoxins.

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2894%2900333-5

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0006-2952(94)00333-5

1 reference

20 September 2017

1 reference