(Q40401298)

20 September 2017

title

Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases (English)

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20 September 2017

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Ulrike Sommer

1

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20 September 2017

Christine Schmid

2

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20 September 2017

Radoslaw M Sobota

3

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20 September 2017

Ute Lehmann

4

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20 September 2017

Nigel J Stevenson

5

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20 September 2017

James A Johnston

6

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20 September 2017

Fred Schaper

7

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20 September 2017

Peter C Heinrich

8

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20 September 2017

Serge Haan

9

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20 September 2017

language of work or name

English

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publication date

6 July 2005

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Journal of Biological Chemistry

20 September 2017

number of pages

11

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based on heuristic

inferred from page(s)

published in

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20 September 2017

volume

280

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20 September 2017

issue

36

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20 September 2017

page(s)

31478-31488

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Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

20 September 2017

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Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells

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Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

21 January 2018

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Principles of interleukin (IL)-6-type cytokine signalling and its regulation

21 January 2018

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Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130.

21 January 2018

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Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components

21 January 2018

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Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses

21 January 2018

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Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors

21 January 2018

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Differential Activation of Acute Phase Response Factor/STAT3 and STAT1 via the Cytoplasmic Domain of the Interleukin 6 Signal Transducer gp130

21 January 2018

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Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level

21 January 2018

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Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression

21 January 2018

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Protein tyrosine phosphatase 2 (SHP-2) moderates signaling by gp130 but is not required for the induction of acute-phase plasma protein genes in hepatic cells

21 January 2018

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SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130

21 January 2018

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Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

21 January 2018

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SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130

21 January 2018

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Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis.

21 January 2018

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A family of cytokine-inducible inhibitors of signalling

21 January 2018

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A new protein containing an SH2 domain that inhibits JAK kinases

21 January 2018

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Structure and function of a new STAT-induced STAT inhibitor

21 January 2018

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Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

21 January 2018

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SOCS3 negatively regulates IL-6 signaling in vivo

21 January 2018

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IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

21 January 2018

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SOCS3 regulates the plasticity of gp130 signaling

21 January 2018

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The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

21 January 2018

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Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain

21 January 2018

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The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

21 January 2018

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The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

21 January 2018

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The SOCS box: a tale of destruction and degradation

21 January 2018

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Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase

21 January 2018

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The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.

21 January 2018

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Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation

21 January 2018

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Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.

21 January 2018

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Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation.

21 January 2018

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SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M506008200

SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506008200

Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M506008200

Insulin induces suppressor of cytokine signaling-3 tyrosine phosphorylation through janus-activated kinase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M506008200

Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation

21 January 2018

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A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor

21 January 2018

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Janus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase

21 January 2018

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Mapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction

21 January 2018

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Novel role of Janus kinase 1 in the regulation of oncostatin M receptor surface expression.

21 January 2018

1 reference

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The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506008200

Long term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506008200

Regulation of the Jak2 tyrosine kinase by its pseudokinase domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506008200

Src family kinases are required for integrin but not PDGFR signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506008200

Association between the PDGF receptor and members of the src family of tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506008200

Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506008200

Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association

21 January 2018

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pp60c-src activation in human colon carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506008200

Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506008200

Signaling through a novel domain of gp130 mediates cell proliferation and activation of Hck and Erk kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506008200

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506008200

Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506008200

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506008200

Elongin BC complex prevents degradation of von Hippel-Lindau tumor suppressor gene products

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506008200

A molecular basis for stabilization of the von Hippel-Lindau (VHL) tumor suppressor protein by components of the VHL ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506008200

v-Abl signaling disrupts SOCS-1 function in transformed pre-B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506008200

Recombinant human interleukin-6 (IL-6/BSF-2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506008200

21 January 2018

Identifiers

DOI

10.1074/JBC.M506008200

1 reference

20 September 2017

1 reference