(Q40403939)

English

Binding of the Methyl Donor S-Adenosyl-l-Methionine to Middle East Respiratory Syndrome Coronavirus 2'-O-Methyltransferase nsp16 Promotes Recruitment of the Allosteric Activator nsp10.

scientific article published on 28 December 2016

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28031370%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Binding of the Methyl Donor S-Adenosyl-l-Methionine to Middle East Respiratory Syndrome Coronavirus 2'-O-Methyltransferase nsp16 Promotes Recruitment of the Allosteric Activator nsp10 (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28031370%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Middle East respiratory syndrome coronavirus

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Middle East respiratory syndrome

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based on heuristic

inferred from title

Jean-Jacques Vasseur

3

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Europe PubMed Central

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4 April 2020

Francoise Debart

4

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4 April 2020

5

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4 April 2020

Etienne Decroly

6

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4 April 2020

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Wahiba Aouadi

1

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4 April 2020

Alexandre Blanjoie

2

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4 April 2020

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14 February 2017

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4 April 2020

Journal of Virology

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4 April 2020

91

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4 April 2020

5

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Europe PubMed Central

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4 April 2020

Middle East Respiratory Syndrome: Emergence of a Pathogenic Human Coronavirus

1 reference

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22 September 2017

Molecular basis of RNA guanine-7 methyltransferase (RNMT) activation by RAM.

1 reference

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22 September 2017

SARS and MERS: recent insights into emerging coronaviruses

1 reference

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22 September 2017

Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals

1 reference

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22 September 2017

Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.

1 reference

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22 September 2017

Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia

1 reference

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22 September 2017

Middle East respiratory syndrome coronavirus: transmission, virology and therapeutic targeting to aid in outbreak control

1 reference

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22 September 2017

A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2'O-Methylated Self RNA.

1 reference

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22 September 2017

Coronavirus nsp10/nsp16 Methyltransferase Can Be Targeted by nsp10-Derived Peptide In Vitro and In Vivo To Reduce Replication and Pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309940

22 September 2017

Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309940

22 September 2017

Innate immune restriction and antagonism of viral RNA lacking 2׳-O methylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309940

22 September 2017

Severe neurologic syndrome associated with Middle East respiratory syndrome corona virus (MERS-CoV)

1 reference

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22 September 2017

Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309940

22 September 2017

IFIT1: A dual sensor and effector molecule that detects non-2'-O methylated viral RNA and inhibits its translation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309940

22 September 2017

MERS: emergence of a novel human coronavirus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309940

22 September 2017

Attenuation and restoration of severe acute respiratory syndrome coronavirus mutant lacking 2'-o-methyltransferase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309940

22 September 2017

Sequestration by IFIT1 impairs translation of 2'O-unmethylated capped RNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309940

22 September 2017

Rational design of a live attenuated dengue vaccine: 2'-o-methyltransferase mutants are highly attenuated and immunogenic in mice and macaques

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309940

22 September 2017

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309940

22 September 2017

Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309940

22 September 2017

Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309940

22 September 2017

The viral RNA capping machinery as a target for antiviral drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309940

22 September 2017

2'-O methylation of internal adenosine by flavivirus NS5 methyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309940

22 September 2017

Conventional and unconventional mechanisms for capping viral mRNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309940

22 September 2017

Biochemical and Structural Insights into the Mechanisms of SARS Coronavirus RNA Ribose 2′-O-Methylation by nsp16/nsp10 Protein Complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309940

22 September 2017

Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2′-O-Methyltransferase nsp10/nsp16 Complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309940

22 September 2017

Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309940

22 September 2017

Molecular mapping of the RNA Cap 2'-O-methyltransferase activation interface between severe acute respiratory syndrome coronavirus nsp10 and nsp16.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309940

22 September 2017

In vitro reconstitution of SARS-coronavirus mRNA cap methylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309940

22 September 2017

Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309940

22 September 2017

Structural insights into the mechanism and evolution of the vaccinia virus mRNA cap N7 methyl-transferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309940

22 September 2017

Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2'O)-methyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309940

22 September 2017

Methionine metabolism in mammals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309940

22 September 2017

'Cap-tabolism'.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309940

22 September 2017

Human coronavirus 229E nonstructural protein 13: characterization of duplex-unwinding, nucleoside triphosphatase, and RNA 5'-triphosphatase activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309940

22 September 2017

SAM (dependent) I AM: the S-adenosylmethionine-dependent methyltransferase fold

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309940

22 September 2017

Strategies in the design of antiviral drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309940

22 September 2017

3-deazaneplanocin A induces massively increased interferon-alpha production in Ebola virus-infected mice

1 reference

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22 September 2017

A Sm-like protein complex that participates in mRNA degradation

1 reference

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22 September 2017

Virus-encoded proteinases and proteolytic processing in the Nidovirales.

1 reference

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22 September 2017

Structural basis for sequence-nonspecific recognition of 5'-capped mRNA by a cap-modifying enzyme

1 reference

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22 September 2017

S-adenosylhomocysteine hydrolase inhibitors as broad-spectrum antiviral agents

1 reference

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22 September 2017

Middle East respiratory syndrome coronavirus (MERS-CoV) RNA and neutralising antibodies in milk collected according to local customs from dromedary camels, Qatar, April 2014.

1 reference

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17 June 2018

Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions.

1 reference

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17 June 2018

Synthesis of 5' cap-0 and cap-1 RNAs using solid-phase chemistry coupled with enzymatic methylation by human (guanine-N⁷)-methyl transferase.

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17 June 2018

A base-labile group for 2'-OH protection of ribonucleosides: a major challenge for RNA synthesis

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17 June 2018

Coronavirus nonstructural protein 16 is a cap-0 binding enzyme possessing (nucleoside-2'O)-methyltransferase activity

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17 June 2018

Capping of eucaryotic mRNAs

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17 June 2018

mRNA cap-1 methyltransferase in the SARS genome.

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20 August 2018

2001 ASPET Otto Krayer Award Lecture. Molecular targets for antiviral agents

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20 August 2018

Intrinsic RNA (guanine-7) methyltransferase activity of the vaccinia virus capping enzyme D1 subunit is stimulated by the D12 subunit. Identification of amino acid residues in the D1 protein required for subunit association and methyl group transfer

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20 August 2018

Efficient Solid-Phase Chemical Synthesis of 5′-Triphosphates of DNA, RNA, and their Analogues

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2 December 2018

Compartmentalization of S-adenosylhomocysteine in rat liver. Determination and characterization of the in vivo protein binding

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1128/JVI.02217-16

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28031370%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

PMC publication ID

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28031370%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28031370%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

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