(Q40409054)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27977138%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

title

Drugging the Undruggable: Therapeutic Potential of Targeting Protein Tyrosine Phosphatases (English)

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29 March 2020

1

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29 March 2020

author name string

Zhong-Yin Zhang

series ordinal

1

1 reference

PubMed ID

27977138

20 September 2017

language of work or name

English

0 references

publication date

15 December 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27977138%20AND%20SRC:MED&resulttype=core&format=json

Accounts of Chemical Research

29 March 2020

published in

1 reference

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29 March 2020

volume

50

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29 March 2020

issue

1

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29 March 2020

page(s)

122-129

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Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

29 March 2020

cites work

1 reference

12 December 2020

Potent and highly selective inhibitors of the protein tyrosine phosphatase 1B

1 reference

12 December 2020

Structure-based discovery of small molecule inhibitors targeted to protein tyrosine phosphatase 1B

1 reference

12 December 2020

Acquisition of a specific and potent PTP1B inhibitor from a novel combinatorial library and screening procedure

1 reference

12 December 2020

Protein tyrosine phosphatases: structure and function, substrate specificity, and inhibitor development

1 reference

12 December 2020

The combinatorial synthesis of bicyclic privileged structures or privileged substructures.

1 reference

12 December 2020

Aurintricarboxylic acid blocks in vitro and in vivo activity of YopH, an essential virulent factor of Yersinia pestis, the agent of plague.

1 reference

12 December 2020

Cellular effects of small molecule PTP1B inhibitors on insulin signaling

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12 December 2020

Disruption of mptpB impairs the ability of Mycobacterium tuberculosis to survive in guinea pigs.

1 reference

12 December 2020

Protein tyrosine phosphatases in the human genome

1 reference

12 December 2020

Tyrosine phosphatase MptpA of Mycobacterium tuberculosis inhibits phagocytosis and increases actin polymerization in macrophages

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12 December 2020

Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling

1 reference

12 December 2020

Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with age

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12 December 2020

Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases

1 reference

12 December 2020

Parallel synthesis of a multi-substituted benzo[b]furan library.

1 reference

12 December 2020

Tyrosine phosphorylation: thirty years and counting

1 reference

12 December 2020

Acquisition of a potent and selective TC-PTP inhibitor via a stepwise fluorophore-tagged combinatorial synthesis and screening strategy

1 reference

12 December 2020

Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents

1 reference

12 December 2020

Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)

1 reference

12 December 2020

The tyrosine phosphatase Shp2 in development and cancer

1 reference

12 December 2020

Inside the human cancer tyrosine phosphatome

1 reference

12 December 2020

Low molecular weight phosphotyrosine protein phosphatases as emerging targets for the design of novel therapeutic agents

1 reference

12 December 2020

Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance

1 reference

12 December 2020

Mycobacterium tuberculosis protein tyrosine phosphatase (PtpA) excludes host vacuolar-H+-ATPase to inhibit phagosome acidification

1 reference

12 December 2020

Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT.

1 reference

12 December 2020

Small molecule tools for functional interrogation of protein tyrosine phosphatases

1 reference

12 December 2020

A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes

1 reference

12 December 2020

Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transduction

1 reference

12 December 2020

Kinase drug discovery--what's next in the field?

1 reference

12 December 2020

Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold

1 reference

12 December 2020

A facile hydroxyindole carboxylic acid based focused library approach for potent and selective inhibitors of Mycobacterium protein tyrosine phosphatase B

1 reference

12 December 2020

A Potent and Selective Small-Molecule Inhibitor for the Lymphoid-Specific Tyrosine Phosphatase (LYP), a Target Associated with Autoimmune Diseases

1 reference

12 December 2020

Targeting SHP2 for EGFR inhibitor resistant non-small cell lung carcinoma

1 reference

12 December 2020

Therapeutic potential of targeting the oncogenic SHP2 phosphatase

1 reference

12 December 2020

PTPN22: the archetypal non-HLA autoimmunity gene

1 reference

12 December 2020

Protein tyrosine phosphatases as potential therapeutic targets

1 reference

12 December 2020

Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors

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12 December 2020

Small-molecule kinase inhibitors: an analysis of FDA-approved drugs.

1 reference

12 December 2020

PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs

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12 December 2020

Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis

1 reference

12 December 2020

Cefsulodin Inspired Potent and Selective Inhibitors of mPTPB, a Virulent Phosphatase from Mycobacterium tuberculosis

1 reference

12 December 2020

Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus.

1 reference

12 December 2020

Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation

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12 December 2020

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

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12 December 2020

Mycobacterial Protein Tyrosine Phosphatases A and B Inhibitors Augment the Bactericidal Activity of the Standard Anti-tuberculosis Regimen

1 reference

12 December 2020

SHP2 phosphatase as a novel therapeutic target for melanoma treatment

1 reference

12 December 2020

Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism

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12 December 2020

Characterization of the major protein-tyrosine-phosphatases of human placenta.

1 reference

12 December 2020

Why is phosphonodifluoromethyl phenylalanine a more potent inhibitory moiety than phosphonomethyl phenylalanine toward protein-tyrosine phosphatases?

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12 December 2020

Protein tyrosine phosphatase substrate specificity: size and phosphotyrosine positioning requirements in peptide substrates

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12 December 2020

Potent low molecular weight substrates for protein-tyrosine phosphatase

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12 December 2020

Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design

1 reference

12 December 2020

10.1021/ACS.ACCOUNTS.6B00537

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27977138%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

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29 March 2020

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