(Q40410713)

20 September 2017

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title

Transgenic and gene knockout mice in cancer research (English)

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20 September 2017

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J L Viney

1

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20 September 2017

1 June 1995

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Cancer and Metastasis Reviews

20 September 2017

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20 September 2017

14

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20 September 2017

77-90

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20 September 2017

2

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https://scigraph.springernature.com/pub.10.1007/bf00665792

20 September 2017

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cites work

Transforming growth factor alpha dramatically enhances oncogene-induced carcinogenesis in transgenic mouse pancreas and liver

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https://api.crossref.org/works/10.1007%2FBF00665792

Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00665792

Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00665792

Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00665792

High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00665792

Acceleration of mammary neoplasia in transforming growth factor alpha transgenic mice by 7,12-dimethylbenzanthracene

21 January 2018

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12 December 2020

Development of mammary hyperplasia and neoplasia in MMTV-TGF alpha transgenic mice

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12 December 2020

The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells

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12 December 2020

Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice.

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12 December 2020

Transforming growth factor-alpha: an oncodevelopmental growth factor

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12 December 2020

A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice

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12 December 2020

Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice

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12 December 2020

v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid

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12 December 2020

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.

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12 December 2020

Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor alpha in hepatic oncogenesis

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12 December 2020

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

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12 December 2020

Transgenic models of tumor development.

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12 December 2020

Thymocyte apoptosis induced by p53-dependent and independent pathways.

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12 December 2020

Cyclin D1/bcl-1 cooperates with myc genes in the generation of B-cell lymphoma in transgenic mice.

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12 December 2020

Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion

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12 December 2020

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

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12 December 2020

The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice

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12 December 2020

Stifled by inhibitions

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12 December 2020

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

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12 December 2020

Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors

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12 December 2020

Tumor suppressor genes

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12 December 2020

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12 December 2020

TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas

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12 December 2020

Cancer. p53, guardian of the genome

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12 December 2020

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

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12 December 2020

Regulatory imbalances in cell proliferation and cell death during oncogenesis in transgenic mice.

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12 December 2020

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

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12 December 2020

p53 is required for radiation-induced apoptosis in mouse thymocytes

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12 December 2020

Acute leukaemia in bcr/abl transgenic mice

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12 December 2020

Use of transgenic mice to study myc family gene function in normal mammalian development and in cancer.

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12 December 2020

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

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12 December 2020

p53-dependent apoptosis suppresses tumor growth and progression in vivo

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12 December 2020

Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene

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12 December 2020

Pim-1 levels determine the size of early B lymphoid compartments in bone marrow

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12 December 2020

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

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12 December 2020

Two distinct target cells for v-jun mediated wound tumorigenesis.

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12 December 2020

Thymic lymphomas in interleukin 9 transgenic mice

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12 December 2020

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

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12 December 2020

bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

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12 December 2020

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

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12 December 2020

New tumor suppressor may rival p53

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12 December 2020

Induction of epidermal hyperplasia, hyperkeratosis, and papillomas in transgenic mice by a targeted v-Ha-ras oncogene.

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12 December 2020

Targeted c-myc gene expression in mammary glands of transgenic mice induces mammary tumours with constitutive milk protein gene transcription

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12 December 2020

Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities.

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12 December 2020

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

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12 December 2020

In vivo analysis of Pim-1 deficiency

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12 December 2020

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

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12 December 2020

Differential effects of Bcl-2 on T and B cells in transgenic mice

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12 December 2020

Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene

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12 December 2020

Oncogenic conversion of transcription factors by chromosomal translocations

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12 December 2020

Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice

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12 December 2020

Transgenic mice bearing the human c-myc gene activated by an immunoglobulin enhancer: a pre-B-cell lymphoma model

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12 December 2020

Apoptotic cell death induced by c-myc is inhibited by bcl-2.

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12 December 2020

Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1.

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12 December 2020

Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast

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12 December 2020

Requirement for a functional Rb-1 gene in murine development

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12 December 2020

Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop

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12 December 2020

Oncogene-induced liver neoplasia in transgenic mice.

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12 December 2020

Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations

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12 December 2020

Identification and analysis of tumor suppressor genes using transgenic mouse models.

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12 December 2020

Targeting expression of a transforming growth factor beta 1 transgene to the pregnant mammary gland inhibits alveolar development and lactation.

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12 December 2020

Effects of an Rb mutation in the mouse

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12 December 2020

Molecular dissection of multi-stage tumorigenesis in transgenic mice

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12 December 2020

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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12 December 2020

Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes

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12 December 2020

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo

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12 December 2020

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

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12 December 2020

Growth factors and cancer

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12 December 2020

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

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12 December 2020

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

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12 December 2020

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

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12 December 2020

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

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12 December 2020

Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter

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12 December 2020

Transgenic mice provide genetic evidence that transforming growth factor alpha promotes skin tumorigenesis via H-ras-dependent and H-ras-independent pathways.

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12 December 2020

Identifiers

DOI

10.1007/BF00665792

1 reference

PubMed ID

7554032

Dimensions Publication ID

20 September 2017

0 references

1 reference

PubMed ID

7554032