(Q40419495)

20 September 2017

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title

Physiologically-based pharmacokinetic modeling and bioactivation of xenobiotics (English)

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20 September 2017

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H J Clewell

1

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20 September 2017

M E Andersen

series ordinal

2

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20 September 2017

language of work or name

English

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publication date

1 January 1994

1 reference

Toxicology and Industrial Health

20 September 2017

published in

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20 September 2017

volume

10

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20 September 2017

issue

1-2

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20 September 2017

page(s)

1-24

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Saturable metabolism and its relationship to toxicity

20 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

Physiologically based pharmacokinetics and the risk assessment process for methylene chloride.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

Quantitative evaluation of the metabolic interactions between trichloroethylene and 1,1-dichloroethylene in vivo using gas uptake methods.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

Physiologically based pharmacokinetic modeling with dichloromethane, its metabolite, carbon monoxide, and blood carboxyhemoglobin in rats and humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

Modeling receptor-mediated processes with dioxin: implications for pharmacokinetics and risk assessment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

Enteric transport of chlordecone (Kepone®) in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

Coupling of computer modeling with in vitro methodologies to reduce animal usage in toxicity testing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

Improving toxicology testing protocols using computer simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

Development of a physiologically based pharmacokinetic model for chloroform

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

Physiologically based pharmacokinetic modeling of the pregnant rat: a multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

Physiologically based pharmacokinetic modeling of the lactating rat and nursing pup: a multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

Metabolism of inhaled brominated hydrocarbons: validation of gas uptake results by determination of a stable metabolite.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

In vitro metabolism of methylene chloride in human and animal tissues: use in physiologically based pharmacokinetic models

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

A physiologically based simulation approach for determining metabolic constants from gas uptake data

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

Physiologically based pharmacokinetic and pharmacodynamic model for the inhibition of acetylcholinesterase by diisopropylfluorophosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

Physiologically Based Pharmacokinetic Modeling: Principles and Applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

A review of the applications of physiologically based pharmacokinetic modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

Development and utilization of physiologically based pharmacokinetic models for toxicological applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

What is an appropriate measure of exposure when testing drugs for carcinogenicity in rodents?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

A physiologically based pharmacokinetic model for inhaled carbon tetrachloride

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

Pharmacokinetics of inhaled styrene in human volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

A vial-equilibration method to evaluate the drug-metabolizing enzyme activity for volatile hydrocarbons

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

Determination of the kinetic constants for metabolism of inhaled toxicants in vivo using gas uptake measurements

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

Inhalation pharmacokinetics: Evaluating systemic extraction, total in vivo metabolism, and the time course of enzyme induction for inhaled styrene in rats based on arterial blood:Inhaled air concentration ratios

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

Metabolism of inhaled dihalomethanes in vivo: Differentiation of kinetic constants for two independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

A physiologically based pharmacokinetic model for 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J and DBA/2J mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

A physiological pharmacokinetic model for dermal absorption of vapors in the rat*1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

Polychlorotrifluoroethylene (PCTFE) oligomer pharmacokinetics in Fischer 344 rats: Development of a physiologically based model*1, *2

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F074823379401000101

10.1177/074823379401000101

21 January 2018

Identifiers

DOI

0 references

1 reference