(Q40432300)

20 September 2017

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title

Antiplatelet drugs. A comparative review (English)

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20 September 2017

K Schrör

1

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20 September 2017

publication date

1 July 1995

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20 September 2017

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20 September 2017

volume

50

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20 September 2017

issue

1

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20 September 2017

page(s)

7-28

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https://scigraph.springernature.com/pub.10.2165/00003495-199550010-00002

20 September 2017

exact match

0 references

cites work

Anticoagulant activity of Hirulog, a direct thrombin inhibitor, in humans

1 reference

12 December 2020

Shear-induced platelet aggregation in cerebral ischemia

1 reference

12 December 2020

Aspirin-induced decline in prostacyclin production in patients with coronary artery disease is due to decreased endoperoxide shift. Analysis of the effects of a combination of aspirin and n-3 fatty acids on the eicosanoid profile

1 reference

12 December 2020

The structure of a complex of recombinant hirudin and human alpha-thrombin

1 reference

12 December 2020

The pharmacological modulation of thrombin-induced cerebral thromboembolism in the rabbit

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12 December 2020

Combined thromboxane A2 synthase inhibition and prostaglandin endoperoxide receptor antagonism limits myocardial infarct size after mechanical coronary occlusion and reperfusion at doses enhancing coronary thrombolysis by streptokinase

1 reference

12 December 2020

Redirection of arachidonic acid metabolism by ICI D1542: effects on thrombus formation in the coronary artery of the anaesthetized dog.

1 reference

12 December 2020

Synthetic low-molecular weight thrombin inhibitors: molecular design and pharmacological profile

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12 December 2020

Increased Prostacyclin Biosynthesis in Patients with Severe Atherosclerosis and Platelet Activation

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12 December 2020

Thrombin plays a key role in late platelet thrombus growth and/or stability. Effect of a specific thrombin inhibitor on thrombogenesis induced by aortic subendothelium exposed to flowing rabbit blood

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12 December 2020

Effects of a thromboxane synthetase inhibitor and a cAMP phosphodiesterase inhibitor, singly and in combination, on platelet behaviour

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12 December 2020

Differential Inhibition by Aspirin of Vascular and Platelet Prostaglandin Synthesis in Atherosclerotic Patients

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12 December 2020

Shear-induced platelet aggregation can be mediated by vWF released from platelets, as well as by exogenous large or unusually large vWF multimers, requires adenosine diphosphate, and is resistant to aspirin

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12 December 2020

Experimental studies on the antithrombotic action of a highly effective synthetic thrombin inhibitor

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12 December 2020

Pharmacodynamic study of F(ab')2 fragments of murine monoclonal antibody 7E3 directed against human platelet glycoprotein IIb/IIIa in patients with unstable angina pectoris

1 reference

12 December 2020

Aspirin does not improve early arterial patency after streptokinase treatment for acute myocardial infarction

1 reference

12 December 2020

Antiplatelet and antithrombotic efficacy of DMP 728, a novel platelet GPIIb/IIIa receptor antagonist

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12 December 2020

Medical treatment for stroke prevention

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12 December 2020

The modification of platelet-induced coronary vasoconstriction by a thromboxane receptor antagonist

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12 December 2020

Suppression of thromboxane A2 but not of systemic prostacyclin by controlled-release aspirin

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12 December 2020

Improved potency and specificity of Arg-Gly-Asp (RGD) containing peptides as fibrinogen receptor blocking drugs

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12 December 2020

Pharmacology of ticlopidine: a review

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12 December 2020

Failure of prostacyclin analog iloprost to sustain coronary blood flow after recombinant tissue-type plasminogen-induced thrombolysis in dogs

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12 December 2020

Initial experience with a direct antithrombin, Hirulog, in unstable angina. Anticoagulant, antithrombotic, and clinical effects

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12 December 2020

Direct thrombin inhibitors in cardiovascular medicine

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12 December 2020

Aspirin as an antiplatelet drug

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12 December 2020

Role of platelets in smooth muscle cell proliferation and migration after vascular injury in rat carotid artery

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12 December 2020

Failure of epoprostenol (prostacyclin, PGI2) to inhibit platelet aggregation and to prevent restenosis after coronary angioplasty: results of a randomised placebo controlled trial

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12 December 2020

Decreased sensitivity of human platelets to PGI2 during long-term intraarterial prostacyclin infusion in patients with peripheral vascular disease--a rebound phenomenon?

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12 December 2020

Comparison of hirudin and heparin as adjuncts to streptokinase thrombolysis in a canine model of coronary thrombosis

1 reference

12 December 2020

Superior activity of a thromboxane receptor antagonist as compared with aspirin in rat models of arterial and venous thrombosis

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12 December 2020

Prevention of restenosis after percutaneous transluminal coronary angioplasty with thromboxane A2-receptor blockade. A randomized, double-blind, placebo-controlled trial. Coronary Artery Restenosis Prevention on Repeated Thromboxane-Antagonism Study

1 reference

12 December 2020

The affinities of prostaglandin H2 and thromboxane A2 for their receptor are similar in washed human platelets

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12 December 2020

Aspirin and human platelets: from clinical trials to acetylation of cyclooxygenase and back

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12 December 2020

Failure of aspirin treatment after stroke

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12 December 2020

Coagulation-fibrinolysis system in poststroke patients receiving antiplatelet medication

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12 December 2020

Clopidogrel--a platelet inhibitor which inhibits thrombogenesis in non-anticoagulated human blood independently of the blood flow conditions

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12 December 2020

Effects of aspirin DL-lysine on thrombin generation in unstable angina pectoris

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12 December 2020

Adenosine diphosphate (ADP)-induced alpha-granules release from platelets of native whole blood is reduced by ticlopidine but not by aspirin or dipyridamole

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12 December 2020

Selection of single-stranded DNA molecules that bind and inhibit human thrombin

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12 December 2020

Antithrombotic effects of recombinant hirudin in experimental angioplasty and intravascular thrombolysis

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12 December 2020

Efficacy of ticlopidine and aspirin for prevention of reversible cerebrovascular ischemic events. The Ticlopidine Aspirin Stroke Study

1 reference

12 December 2020

Platelet functions in recombinant hirudin-anticoagulated blood

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12 December 2020

Differential inhibition of thromboxane A2 and prostacyclin synthesis by low dose acetylsalicylic acid in atherosclerotic patients

1 reference

12 December 2020

Prevention of intra-coronary thrombosis in the anaesthetised dog: the importance of thromboxane A2 and thrombin.

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12 December 2020

The pharmacology of the integrins

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12 December 2020

Comparative arterial antithrombotic activity of clopidogrel and acetyl salicylic acid in the pig

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12 December 2020

Effect of prostaglandin I2 on cyclical reductions of coronary blood flow

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12 December 2020

The stimulation of arachidonic acid metabolism in human platelets by hydrodynamic stresses

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12 December 2020

Platelet aggregation in partially obstructed vessels and its elimination with aspirin.

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12 December 2020

Aspirin, ticlopidine, and stroke

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12 December 2020

Prevention of experimental carotid artery thrombosis by applaggin

1 reference

12 December 2020

Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes. The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIa Investigators

1 reference

12 December 2020

The basic pharmacology of ticlopidine and clopidogrel

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12 December 2020

Low-dose aspirin and stroke. "It ain't necessarily so"

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12 December 2020

Recombinant hirudin for unstable angina pectoris. A multicenter, randomized angiographic trial

1 reference

12 December 2020

A critical appraisal of ticlopidine, a new antiplatelet agent. Effectiveness and clinical indications for prophylaxis of atherosclerotic events

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12 December 2020

Redirection of prostaglandin endoperoxide metabolism at the platelet-vascular interface in man

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12 December 2020

Platelet prostacyclin binding in coronary artery disease

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12 December 2020

Effect of aspirin and epinephrine on experimentally induced thrombogenesis in dogs. A parallelism between in vivo and ex vivo thrombosis models

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12 December 2020

Functionally thrombasthenic state in normal platelets following the administration of ticlopidine

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12 December 2020

Fibrin-targeted recombinant hirudin inhibits fibrin deposition on experimental clots more efficiently than recombinant hirudin

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12 December 2020

Shear-induced platelet aggregation is potentiated by desmopressin and inhibited by ticlopidine

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12 December 2020

Platelet receptor desensitization induced by elevated prostacyclin levels causes platelet-endothelial cell adhesion

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12 December 2020

Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty

1 reference

12 December 2020

The development of hirudin as an antithrombotic drug

1 reference

12 December 2020

Inhibitory effect of clopidogrel on platelet adhesion and intimal proliferation after arterial injury in rabbits

1 reference

12 December 2020

Cost-effectiveness of ticlopidine in preventing stroke in high-risk patients.

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12 December 2020

Aspirin, platelets, and thrombosis: theory and practice.

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12 December 2020

ADP metabolism in vascular tissue, a possible thrombo-regulatory mechanism

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12 December 2020

The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke

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12 December 2020

Persistent thrombin generation in humans during specific thrombin inhibition with hirudin

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12 December 2020

Relative importance of thrombin compared with plasmin-mediated platelet activation in response to plasminogen activation with streptokinase

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12 December 2020

The action of ticlopidine on human platelets. Studies on aggregation, secretion, calcium mobilization and membrane glycoproteins

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12 December 2020

Prevention of myocardial infarction and stroke in patients with intermittent claudication; effects of ticlopidine. Results from STIMS, the Swedish Ticlopidine Multicentre Study

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12 December 2020

Safety observations from the pilot phase of the randomized r-Hirudin for Improvement of Thrombolysis (HIT-III) study. A study of the Arbeitsgemeinschaft Leitender Kardiologischer Krankenhausärzte (ALKK)

1 reference

12 December 2020

Prevention of reocclusion by MCI-9038, a thrombin inhibitor, following t-PA-induced thrombolysis in a canine model of femoral arterial thrombosis

1 reference

12 December 2020

Collaborative overview of randomised trials of antiplatelet therapy--I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists' Collaboration

1 reference

12 December 2020

Randomized trial of a GPIIb/IIIa platelet receptor blocker in refractory unstable angina. European Cooperative Study Group

1 reference

12 December 2020

Effectiveness of recombinant desulphatohirudin in reducing restenosis after balloon angioplasty of atherosclerotic femoral arteries in rabbits

1 reference

12 December 2020

Usefulness and tolerability of hirulog, a direct thrombin-inhibitor, in unstable angina pectoris.

1 reference

12 December 2020

Effects of antithrombotic drugs in a rat model of aspirin-insensitive arterial thrombosis

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12 December 2020

Development of aspirin resistance in persons with previous ischemic stroke.

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12 December 2020

Systemic and transcardiac platelet activity in acute myocardial infarction in man: resistance to prostacyclin

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12 December 2020

Clopidogrel inhibits the binding of ADP analogues to the receptor mediating inhibition of platelet adenylate cyclase

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12 December 2020

Profound inhibition of platelet aggregation with monoclonal antibody 7E3 Fab after thrombolytic therapy. Results of the Thrombolysis and Angioplasty in Myocardial Infarction (TAMI) 8 Pilot Study

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12 December 2020

New antithrombotic strategies for resistant thrombotic processes

1 reference

12 December 2020

In vivo inhibition of acute platelet-dependent thrombosis in a baboon model by Bay U3405, a thromboxane A2-receptor antagonist

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12 December 2020

Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors

1 reference

12 December 2020

A novel nucleotide-based thrombin inhibitor inhibits clot-bound thrombin and reduces arterial platelet thrombus formation

1 reference

12 December 2020

Defibrotide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in vascular disorders

1 reference

12 December 2020

Biologic effects of recombinant hirudin (CGP 39393) in human volunteers. European Hirudin in Thrombosis Group

1 reference

12 December 2020

MK-383 (L-700,462), a selective nonpeptide platelet glycoprotein IIb/IIIa antagonist, is active in man

1 reference

12 December 2020

Ticlopidine. An updated review of its pharmacology and therapeutic use in platelet-dependent disorders

1 reference

12 December 2020

Thromboxane antagonism in experimental canine carotid artery thrombosis

1 reference

12 December 2020

Time course of the effects of a single bolus injection of F(ab')2 fragments of the antiplatelet GPIIb/IIIa antibody 7E3 on arterial eversion graft occlusion, platelet aggregation, and bleeding time in dogs.

1 reference

12 December 2020

Mediation of reocclusion by thromboxane A2 and serotonin after thrombolysis with tissue-type plasminogen activator in a canine preparation of coronary thrombosis.

1 reference

12 December 2020

Thrombin-hirudin complex stability: a comparison with the thrombin-antithrombin III complex

1 reference

12 December 2020

Incomplete Inhibition of Platelet Secretion by Low-dose Aspirin

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12 December 2020

The effect of ticlopidine on platelet functions in acute myocardial infarction. A double blind controlled trial

1 reference

12 December 2020

Recombinant hirudin in patients with chronic, stable coronary artery disease. Safety, half-life, and effect on coagulation parameters

1 reference

12 December 2020

Ticlopidine Does Not Reduce In Vivo Platelet Thromboxane Biosynthesis and Metabolism in Diabetic Patients

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12 December 2020

Determination of r DNA hirudin and A-human thrombin- hirudin complex in plasma samples: enzyme linked immunosorbent assays for hirudin and complex vs. chromogenic thrombin substrate assay

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12 December 2020

Inhibition of thrombosis by a selective fibrinogen receptor antagonist without effect on bleeding time.

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12 December 2020

Lewis A. Conner Memorial Lecture. Mechanisms leading to myocardial infarction: insights from studies of vascular biology

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12 December 2020

Monoclonal antibody against the platelet glycoprotein (GP) IIb/IIIa receptor prevents coronary artery reocclusion after reperfusion with recombinant tissue-type plasminogen activator in dogs

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12 December 2020

Relative antithrombotic effects of monoclonal antibodies targeting different platelet glycoprotein-adhesive molecule interactions in nonhuman primates

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12 December 2020

Cumulative inhibitory effect of low-dose aspirin on vascular prostacyclin and platelet thromboxane production in patients with atherosclerosis

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12 December 2020

Prothrombin activation fragment 1 + 2 and thrombin antithrombin III complexes in patients with angina pectoris: relation to the presence and severity of coronary atherosclerosis

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12 December 2020

Platelet membrane activation markers are predictive for increased risk of acute ischemic events after PTCA

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12 December 2020

High-dose aspirin inhibits shear-induced platelet reaction involving thrombin generation

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12 December 2020

Selective thrombin inhibitors: the next generation of anticoagulants

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12 December 2020

Acceleration of recombinant tissue-type plasminogen activator-induced thrombolysis and prevention of reocclusion by the combination of heparin and the Arg-Gly-Asp-containing peptide bitistatin in a canine model of coronary thrombosis.

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12 December 2020

Isolation and identification of aptamers from defibrotide that act as thrombin antagonists in vitro

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12 December 2020

Antiplatelet effects of ticlopidine are reduced in experimental hypercholesterolemia

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12 December 2020

Safety and efficacy of recombinant hirudin (CGP 39 393) versus heparin in patients with stable angina undergoing coronary angioplasty

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12 December 2020

Thromboxane synthetase inhibitors reduce infarct size by a platelet-dependent, aspirin-sensitive mechanism

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12 December 2020

Interruption of acute platelet-dependent thrombosis by the synthetic antithrombin D-phenylalanyl-L-prolyl-L-arginyl chloromethyl ketone

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12 December 2020

Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugs

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12 December 2020

Effects of low-to-high doses of aspirin on platelet aggregability and metabolites of thromboxane A2 and prostacyclin

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12 December 2020

Role of ticlopidine for prevention of stroke

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12 December 2020

Erythrocytes metabolically enhance collagen-induced platelet responsiveness via increased thromboxane production, adenosine diphosphate release, and recruitment

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12 December 2020

Effects of thrombin inhibition on the development of acute platelet-thrombus deposition during angioplasty in pigs. Heparin versus recombinant hirudin, a specific thrombin inhibitor

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12 December 2020

Thromboxane synthetase inhibition with CGS 13080 improves coronary blood flow after streptokinase-induced thrombolysis

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12 December 2020

Measurement of thrombin generation in whole blood--the effect of heparin and aspirin

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12 December 2020

Development of GPIIb/IIIa antagonists as antithrombotic drugs

1 reference

12 December 2020

Endogenous prostaglandin endoperoxides and prostacyclin modulate the thrombolytic activity of tissue plasminogen activator. Effects of simultaneous inhibition of thromboxane A2 synthase and blockade of thromboxane A2/prostaglandin H2 receptors in a

1 reference

12 December 2020

Effect of heparin, hirudin, and a synthetic thrombin inhibitor on antithrombin III in thrombin-induced disseminated intravascular coagulation in rats

1 reference

12 December 2020

Enhancement of incisional wound healing and neovascularization in normal rats by thrombin and synthetic thrombin receptor-activating peptides

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12 December 2020

Hirudin in acute myocardial infarction. Safety report from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9A Trial

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12 December 2020

Cyclic flow variations after coronary angioplasty in humans: clinical and angiographic characteristics and elimination with 7E3 monoclonal antiplatelet antibody

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12 December 2020

Distinct receptors and signaling pathways in alpha-thrombin- and thrombin receptor peptide-induced vascular contractions

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12 December 2020

Ticlopidine and clopidogrel (SR 25990C) selectively neutralize ADP inhibition of PGE1-activated platelet adenylate cyclase in rats and rabbits

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12 December 2020

The in vivo antiplatelet effects of thromboxane A2 synthase inhibitors are potentiated by simultaneous thromboxane A2/prostaglandin H2 receptor blockade

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12 December 2020

Clopidogrel is more effective than aspirin as adjuvant treatment to prevent reocclusion after thrombolysis

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12 December 2020

Inhibition of platelet function by an aspirin-insensitive endothelial cell ADPase. Thromboregulation by endothelial cells

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12 December 2020

Prevention of arterial thrombosis by a monoclonal antibody against the 100 to 109 amino acid sequence stretch of the beta-subunit of the human platelet fibrinogen receptor: a comparative study with low dose aspirin

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12 December 2020

Role of thrombin and thromboxane A2 in reocclusion following coronary thrombolysis with tissue-type plasminogen activator

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12 December 2020

Inhibition of growth of thrombus on fresh mural thrombus. Targeting optimal therapy

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12 December 2020

Combined ADP and thromboxane A2 antagonism prevents cyclic flow variations in stenosed and endothelium-injured arteries in nonhuman primates

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12 December 2020

Increased thromboxane biosynthesis in patients with acute cerebral ischemia

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12 December 2020

Experimental carotid thrombosis in the guinea pig

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12 December 2020

Effects of low-dose aspirin on endogenous eicosanoid formation in normal and atherosclerotic men

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12 December 2020

Influence of selective endoperoxide/thromboxane A2 receptor antagonism with sulotroban on lysis time and reocclusion rate after tissue plasminogen activator-induced coronary thrombolysis in the dog

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12 December 2020

Rapid and sustained coronary artery recanalization with combined bolus injection of recombinant tissue-type plasminogen activator and monoclonal antiplatelet GPIIb/IIIa antibody in a canine preparation

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12 December 2020

RANDOMISED TRIAL OF INTRAVENOUS STREPTOKINASE, ORAL ASPIRIN, BOTH, OR NEITHER AMONG 17 187 CASES OF SUSPECTED ACUTE MYOCARDIAL INFARCTION: ISIS-2

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12 December 2020

Randomized trial of ridogrel, a combined thromboxane A2 synthase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor antagonist, versus aspirin as adjunct to thrombolysis in patients with acute myocardial infarction. The Ridogrel Versus

1 reference

12 December 2020

Dose-dependent effect of aspirin on carotid atherosclerosis

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12 December 2020

Drugs and surgery in the prevention of ischemic stroke

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12 December 2020

Norepinephrine-induced human platelet activation in vivo is only partly counteracted by aspirin.

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12 December 2020

Epinephrine potentiates human platelet activation but is not an aggregating agent

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12 December 2020

Preliminary clinical studies with thromboxane synthase inhibitors and thromboxane receptor blockers. A review

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12 December 2020

Hirudin and Platelets

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12 December 2020

Effects of streptokinase and recombinant tissue plasminogen activator on platelet aggregation in whole blood

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12 December 2020

Aspirin does not affect the flow cytometric detection of fibrinogen binding to, or release of alpha-granules or lysosomes from, human platelets

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12 December 2020

[Pathophysiology and treatment of thrombosis. (2) The effect of ticlopidine on TIA compared with aspirin. A double-blind, 12-month and open 24-month follow-up study]

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12 December 2020

Anticoagulant effects of hirulog, a novel thrombin inhibitor, in patients with coronary artery disease

1 reference

12 December 2020

Adenylate cyclase activation determines the effect of thromboxane synthase inhibitors on platelet aggregation in vitro. Comparison of platelets from responders and nonresponders

1 reference

12 December 2020

Local delivery of an antithrombin inhibits platelet-dependent thrombosis

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12 December 2020

Prostaglandin endoperoxides modulate the response to thromboxane synthase inhibition during coronary thrombosis

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12 December 2020

Aspirin does not inhibit adenosine diphosphate-induced platelet alpha-granule release

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12 December 2020

Randomised trial of coronary intervention with antibody against platelet IIb/IIIa iritegrin for reduction of clinical restenosis: results at six months

1 reference

12 December 2020

Ticlopidine inhibits platelet thrombus formation studied in a flowing system

1 reference

12 December 2020

Prevention of experimental coronary thrombosis by hirudin

1 reference

12 December 2020

ADP plays an important role in mediating platelet aggregation and cyclic flow variations in vivo in stenosed and endothelium-injured canine coronary arteries

1 reference

12 December 2020

Ticlopidine facilitates the deaggregation of human platelets aggregated by thrombin

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12 December 2020

A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients. Ticlopidine Aspirin Stroke Study Group

1 reference

12 December 2020

Inhibitory effect of acetylsalicylic acid on platelet function in patients with completed stroke or reversible ischemic neurologic deficit

1 reference

12 December 2020

Prevention of platelet-rich arterial thrombosis by selective thrombin inhibition

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12 December 2020

Pharmacodynamics of chimeric glycoprotein IIb/IIIa integrin antiplatelet antibody Fab 7E3 in high-risk coronary angioplasty.

1 reference

12 December 2020

Monoclonal antibodies to platelet glycoprotein IIb/IIIa as antithrombotic agents

1 reference

12 December 2020

10.2165/00003495-199550010-00002

Identifiers

DOI

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Dimensions Publication ID

20 September 2017

1048825104

0 references

1 reference