(Q40445359)

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Heterodimerization and functional interaction between EGF receptor family members: a new signaling paradigm with implications for breast cancer research

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scholarly article

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Europe PubMed Central

PubMed publication ID

20 September 2017

1 reference

Europe PubMed Central

Heterodimerization and functional interaction between EGF receptor family members: a new signaling paradigm with implications for breast cancer research (English)

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

protein heterodimerization activity

1 reference

based on heuristic

inferred from title

Thomas L. Dawson

2

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

author name string

H S Earp

1

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

X Li

3

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

H Yu

4

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

language of work or name

0 references

publication date

1 July 1995

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Breast Cancer Research and Treatment

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

35

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

115-132

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

https://scigraph.springernature.com/pub.10.1007/bf00694752

0 references

In vivo binding properties of SH2 domains from GTPase-activating protein and phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1007%2FBF00694752

21 January 2018

Torso, a receptor tyrosine kinase required for embryonic pattern formation, shares substrates with the sevenless and EGF-R pathways in Drosophila

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

c-erbB-2 expression and response to adjuvant therapy in women with node-positive early breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human epidermal growth factor receptor residue covalently cross-linked to epidermal growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal growth factor (EGF) stimulates EGF receptor synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neu and its ligands: from an oncogene to neural factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct interaction of a ligand for the erbB2 oncogene product with the EGF receptor and p185erbB2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The insulin signaling system

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of extracellular signal-regulated protein kinase-1 (ERK-1; pp44/mitogen-activated protein kinase) by epidermal growth factor and nerve growth factor in PC12 cells: implication of ERK1 inhibitory activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterodimerization of epidermal growth factor receptor and wild-type or kinase-deficient Neu: a mechanism of interreceptor kinase activation and transphosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogene

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: a mechanism for receptor transregulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth factor signaling by receptor tyrosine kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of growth control in normal and malignant breast epithelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oncogenes and signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neu-oncogene: signal transduction pathways, transformation mechanisms and evolving therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The erbB3 gene product is a receptor for heregulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The SH2 domain protein GRB-7 is co-amplified, overexpressed and in a tight complex with HER2 in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Demonstration of ligand-dependent signaling by the erbB-3 tyrosine kinase and its constitutive activation in human breast tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New insights into protein-tyrosine kinase receptor signaling complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Closing in on SH2 specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autocrine and paracrine growth regulation of breast cancer: clinical implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intermolecular association of the p185neu protein and EGF receptor modulates EGF receptor function

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal growth factor (EGF) and hormones stimulate phosphoinositide hydrolysis and increase EGF receptor protein synthesis and mRNA levels in rat liver epithelial cells. Evidence for protein kinase C-dependent and -independent pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular themes in oncogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ligand-induced transformation by a noninternalizing epidermal growth factor receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complexity of FGF receptors: genetic basis for structural diversity and functional specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A point mutation in the neu oncogene mimics ligand induction of receptor aggregation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein tyrosine phosphatases

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SH2 domain specificity and activity modified by a single residue

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The carboxyl terminus of epidermal growth factor receptor/erbB-2 chimerae is internalization impaired.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and mRNA expression analysis of a novel human protooncogene, c-mer

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human breast cancer: prognostic significance of the c-erbB-2 oncoprotein compared with epidermal growth factor receptor, DNA ploidy, and conventional pathologic features

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The regulation of transcription by phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ligand and p185c-neu density govern receptor interactions and tyrosine kinase activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Shc products are substrates of erbB-2 kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulatory and inhibitory growth factors and breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Bruton's tyrosine kinase gene is expressed throughout B cell differentiation, from early precursor B cell stages preceding immunoglobulin gene rearrangement up to mature B cell stages

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein-tyrosine kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SH2 domains recognize specific phosphopeptide sequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

How receptor tyrosine kinases activate Ras.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal growth factor stimulates the synthesis of its own receptor in a human breast cancer cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amphiregulin, epidermal growth factor receptor, and estrogen receptor expression in human primary breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of the neu/p185 and EGF receptor tyrosine kinases: implications for cellular transformation and tumor therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of epidermal growth factor receptor aggregation by an antibody directed against the epidermal growth factor receptor extracellular domain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heregulin induces tyrosine phosphorylation of HER4/p180erbB4

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional analysis of the ligand binding site of EGF-receptor utilizing chimeric chicken/human receptor molecules.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signalling by receptor tyrosine kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SH2 and SH3 domains: from structure to function

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autocrine interaction between TGF alpha and the EGF-receptor: quantitative requirements for induction of the malignant phenotype.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HER2 cytoplasmic domain generates normal mitogenic and transforming signals in a chimeric receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonreceptor tyrosine protein kinases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine kinase receptors in the control of epithelial growth and morphogenesis during development

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amplification of a novel v-erbB-related gene in a human mammary carcinoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A chimeric EGF-R-neu proto-oncogene allows EGF to regulate neu tyrosine kinase and cell transformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Src family of tyrosine protein kinases in hemopoietic signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal growth factor regulates the expression of its own receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

neu(c-erbB-2/HER2) and the epidermal growth factor receptor (EGFR) in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of activation of the TGF-beta receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal Growth Factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of heregulin, a specific activator of p185erbB2

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-type specific interaction of Neu differentiation factor (NDF/heregulin) with Neu/HER-2 suggests complex ligand-receptor relationships

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extracellular signals and reversible protein phosphorylation: what to Mek of it all.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The HER2 (c-erbB-2) oncogene is frequently amplified in in situ carcinomas of the breast

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7612898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF00694752

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

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