(Q40446145)

English

A cis-acting element in the 3'-untranslated region of human TNF-alpha mRNA renders splicing dependent on the activation of protein kinase PKR.

scientific article

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scholarly article

1 reference

Europe PubMed Central

20 September 2017

A cis-acting element in the 3'-untranslated region of human TNF-alpha mRNA renders splicing dependent on the activation of protein kinase PKR. (English)

1 reference

Europe PubMed Central

20 September 2017

0 references

author name string

F Osman

1

1 reference

Europe PubMed Central

20 September 2017

N Jarrous

2

1 reference

Europe PubMed Central

20 September 2017

Y Ben-Asouli

3

1 reference

Europe PubMed Central

20 September 2017

R Kaempfer

4

1 reference

Europe PubMed Central

20 September 2017

publication date

1 December 1999

1 reference

Europe PubMed Central

20 September 2017

Genes & Development

1 reference

Europe PubMed Central

20 September 2017

13

1 reference

Europe PubMed Central

20 September 2017

3280-3293

1 reference

Europe PubMed Central

20 September 2017

24

1 reference

Europe PubMed Central

20 September 2017

T cell receptor (TCR) engagement leads to activation-induced splicing of tumor necrosis factor (TNF) nuclear pre-mRNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

Regulation of adenovirus alternative RNA splicing by dephosphorylation of SR proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

Binding of the protein kinase PKR to RNAs with secondary structure defects: role of the tandem A-G mismatch and noncontiguous helixes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

Ultrastructural localization of interferon-inducible double-stranded RNA-activated enzymes in human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

Potential Alu function: regulation of the activity of double-stranded RNA-activated kinase PKR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

The dynamics of a pre-mRNA splicing factor in living cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

Induction of CD4 expression and human immunodeficiency virus type 1 replication by mutants of the interferon-inducible protein kinase PKR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

Paradoxical interactions between human delta hepatitis agent RNA and the cellular protein kinase PKR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

Minor-groove recognition of double-stranded RNA by the double-stranded RNA-binding domain from the RNA-activated protein kinase PKR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

2-Aminopurine selectively inhibits splicing of tumor necrosis factor alpha mRNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

In vitro activation of the interferon-induced, double-stranded RNA-dependent protein kinase PKR by RNA from the 3' untranslated regions of human alpha-tropomyosin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

A serine kinase regulates intracellular localization of splicing factors in the cell cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

Mechanism of interferon action: structure of the mouse PKR gene encoding the interferon-inducible RNA-dependent protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

Mechanism of interferon action: evidence for intermolecular autophosphorylation and autoactivation of the interferon-induced, RNA-dependent protein kinase PKR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

Regulation of interleukin 2 gene expression by CD28 costimulation in mouse T-cell clones: both nuclear and cytoplasmic RNAs are regulated with complex kinetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

2-Aminopurine selectively blocks the transcriptional activation of cellular genes by virus, double-stranded RNA and interferons in human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

On finding all suboptimal foldings of an RNA molecule

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

Human tumor necrosis factor alpha gene regulation by virus and lipopolysaccharide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

Translational control in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

RNA processing is a limiting step for murine tumor necrosis factor beta expression in response to interleukin-2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

A conserved double-stranded RNA-binding domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

Phosphorylation of initiation factor elF-2 and the control of reticulocyte protein synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

22 September 2017

The eIF-2 alpha protein kinases, regulators of translation in eukaryotes from yeasts to humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

25 September 2017

Platelet-derived growth factor signal transduction through the interferon-inducible kinase PKR. Immediate early gene induction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

25 September 2017

Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

15 June 2018

The regulation of the protein kinase PKR by RNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

15 June 2018

Functional characterization of the RNA-binding domain and motif of the double-stranded RNA-dependent protein kinase DAI (PKR).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

15 June 2018

Nuclear localization of the interferon-inducible protein kinase PKR in human cells and transfected mouse cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

15 June 2018

Regulation of pre-mRNA processing by src.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

15 June 2018

The interferon-inducible protein kinase PKR modulates the transcriptional activation of immunoglobulin kappa gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

15 June 2018

Interactions between the double-stranded RNA binding motif and RNA: definition of the binding site for the interferon-induced protein kinase DAI (PKR) on adenovirus VA RNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

15 June 2018

Tumour necrosis factors alpha and beta inhibit virus replication and synergize with interferons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

15 June 2018

Differential regulation of lymphotoxin and tumor necrosis factor genes in human T lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

15 June 2018

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

15 June 2018

Surprising specificity of PKR binding to delta agent genomic RNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

20 August 2018

Splicing of Balbiani ring 1 gene pre-mRNA occurs simultaneously with transcription.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

20 August 2018

HIV-1 TAR RNA has an intrinsic ability to activate interferon-inducible enzymes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

20 August 2018

Messenger ribonucleic acid specificity in the inhibition of eukaryotic translation by double-stranded RNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317206

20 August 2018

Distribution of pre-mRNA splicing factors at sites of RNA polymerase II transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/10617576

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of the 3′ external transcribed spacer in yeast pre-rRNA processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/10617576

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactive effects of the tumor necrosis factor promoter and 3'-untranslated regions

1 reference

https://pubmed.ncbi.nlm.nih.gov/10617576

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2-Aminopurine inhibits the double-stranded RNA-dependent protein kinase both in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/10617576

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of human interleukin-1 gene expression by retinoic acid and its regulation at processing of precursor transcripts

1 reference

https://pubmed.ncbi.nlm.nih.gov/10617576

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Post-transcriptional regulation of human interleukin-2 gene expression at processing of precursor transcripts

1 reference

https://pubmed.ncbi.nlm.nih.gov/10617576

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A model for the double-stranded RNA (dsRNA)-dependent dimerization and activation of the dsRNA-activated protein kinase PKR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10617576

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1101/GAD.13.24.3280

1 reference

Europe PubMed Central

20 September 2017

1 reference

Europe PubMed Central

20 September 2017

1 reference

Europe PubMed Central

20 September 2017

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