(Q40454536)

English

Critical biophysical properties in the Pseudomonas aeruginosa efflux gene regulator MexR are targeted by mutations conferring multidrug resistance.

scientific article published on April 2010

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scholarly article

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17 January 2020

Critical biophysical properties in the Pseudomonas aeruginosa efflux gene regulator MexR are targeted by mutations conferring multidrug resistance (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20095047%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

multiple drug resistance

1 reference

based on heuristic

inferred from title

Pseudomonas aeruginosa

1 reference

based on heuristic

inferred from title

Cecilia Andresen

1

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17 January 2020

3

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17 January 2020

5

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17 January 2020

Lars-Göran Mårtensson

9

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17 January 2020

author name string

Shah Jalal

2

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17 January 2020

Yi Wang

4

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17 January 2020

Anngelica Jarl

6

1 reference

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17 January 2020

Bo Liedberg

7

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17 January 2020

Bengt Wretlind

8

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17 January 2020

Maria Sunnerhagen

10

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17 January 2020

publication date

1 April 2010

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17 January 2020

Protein Science

1 reference

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17 January 2020

19

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17 January 2020

4

1 reference

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17 January 2020

680-692

1 reference

Europe PubMed Central

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17 January 2020

Linking folding and binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

Structure of the transcriptional regulator LmrR and its mechanism of multidrug recognition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

The crystal structure of MexR from Pseudomonas aeruginosa in complex with its antirepressor ArmR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

The Pseudomonas aeruginosa multidrug efflux regulator MexR uses an oxidation-sensing mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

Structural insight on the mechanism of regulation of the MarR family of proteins: high-resolution crystal structure of a transcriptional repressor from Methanobacterium thermoautotrophicum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

Structural mechanism of organic hydroperoxide induction of the transcription regulator OhrR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

Multidrug-binding transcription factor QacR binds the bivalent aromatic diamidines DB75 and DB359 in multiple positions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

Protein modulator of multidrug efflux gene expression in Pseudomonas aeruginosa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

Crystal Structures of Multidrug Binding Protein TtgR in Complex with Antibiotics and Plant Antimicrobials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

Molecular mechanisms of antibacterial multidrug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

Ligand-responsive transcriptional regulation by members of the MarR family of winged helix proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

Efflux-mediated antimicrobial resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

HucR, a novel uric acid-responsive member of the MarR family of transcriptional regulators from Deinococcus radiodurans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

Toward an integrated model of protein-DNA recognition as inferred from NMR studies on the Lac repressor system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

DICHROWEB, an online server for protein secondary structure analyses from circular dichroism spectroscopic data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

Amino acid substitutions in a long flexible sequence influence thermodynamics and internal dynamic properties of winged helix protein genesis and its DNA complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

Efflux as a mechanism of resistance to antimicrobials in Pseudomonas aeruginosa and related bacteria: unanswered questions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

Crystal Structure of Enterococcus faecalis SlyA-like Transcriptional Factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

Structural biology of bacterial multidrug resistance gene regulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

Structural mechanisms of multidrug recognition and regulation by bacterial multidrug transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

The mexR repressor of the mexAB-oprM multidrug efflux operon in Pseudomonas aeruginosa: characterization of mutations compromising activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

Crystal structure of the MexR repressor of the mexRAB-oprM multidrug efflux operon of Pseudomonas aeruginosa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

Disordered to ordered folding in the regulation of diphtheria toxin repressor activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

The crystal structure of MarR, a regulator of multiple antibiotic resistance, at 2.3 A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

Proline in α-helical kink is required for folding kinetics but not for kinked structure, function, or stability of heat shock transcription factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

MexR repressor of the mexAB-oprM multidrug efflux operon of Pseudomonas aeruginosa: identification of MexR binding sites in the mexA-mexR intergenic region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

Efflux-mediated resistance to fluoroquinolones in gram-positive bacteria and the mycobacteria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

Winged helix proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

In vivo emergence of multidrug-resistant mutants of Pseudomonas aeruginosa overexpressing the active efflux system MexA-MexB-OprM.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

Analysis of data from the analytical ultracentrifuge by nonlinear least-squares techniques

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

Calculation of protein extinction coefficients from amino acid sequence data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

22 September 2017

A self-consistent method for the analysis of protein secondary structure from circular dichroism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

17 June 2018

Analysis of protein circular dichroism spectra for secondary structure using a simple matrix multiplication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

17 June 2018

A test of the linear extrapolation of unfolding free energy changes over an extended denaturant concentration range

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

17 June 2018

Transketolase A, an enzyme in central metabolism, derepresses the marRAB multiple antibiotic resistance operon of Escherichia coli by interaction with MarR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

20 August 2018

Structure of an OhrR-ohrA operator complex reveals the DNA binding mechanism of the MarR family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

20 August 2018

Negative cooperativity of uric acid binding to the transcriptional regulator HucR from Deinococcus radiodurans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

20 August 2018

Bacteriostatic and bactericidal activities of eight fluoroquinolones against MexAB-OprM-overproducing clinical strains of Pseudomonas aeruginosa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

20 August 2018

The hyperthermophile protein Sso10a is a dimer of winged helix DNA-binding domains linked by an antiparallel coiled coil rod.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

20 August 2018

Role of efflux pumps and mutations in genes for topoisomerases II and IV in fluoroquinolone-resistant Pseudomonas aeruginosa strains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

20 August 2018

DICHROWEB: an interactive website for the analysis of protein secondary structure from circular dichroism spectra.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

20 August 2018

Contribution of the MexAB-OprM multidrug efflux system to the beta-lactam resistance of penicillin-binding protein and beta-lactamase-derepressed mutants of Pseudomonas aeruginosa.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

20 August 2018

Mechanisms of quinolone resistance in clinical strains of Pseudomonas aeruginosa.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

20 August 2018

Experimental design for kinetic analysis of protein-protein interactions with surface plasmon resonance biosensors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

20 August 2018

Estimation of globular protein secondary structure from circular dichroism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867009

20 August 2018

Rapid identification of mutations in a multidrug efflux pump in Pseudomonas aeruginosa

1 reference

https://pubmed.ncbi.nlm.nih.gov/20095047

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutational analysis of MarR, the negative regulator of marRAB expression in Escherichia coli, suggests the presence of two regions required for DNA binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/20095047

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanism of MexR-mediated regulation of MexAB-OprM efflux pump expression in Pseudomonas aeruginosa

1 reference

https://pubmed.ncbi.nlm.nih.gov/20095047

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Crystal Structure of the Transcriptional Regulator HucR from Deinococcus radiodurans Reveals a Repressor Preconfigured for DNA Binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/20095047

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two-way interdomain signal transduction in tetracycline repressor

1 reference

https://pubmed.ncbi.nlm.nih.gov/20095047

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20095047

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation in mexR-gene leading to drug resistance in corneal keratitis in human

1 reference

https://pubmed.ncbi.nlm.nih.gov/20095047

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonspecific protein-DNA interactions: complexation of alpha-chymotrypsin with a genomic DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/20095047

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estimation of protein secondary structure and error analysis from circular dichroism spectra

1 reference

https://pubmed.ncbi.nlm.nih.gov/20095047

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/PRO.343

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20095047%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20095047%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20095047%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

ResearchGate publication ID

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